A c.89G>C p.(Gly30Ala) Variant in the DHCR7 Gene as a Cause of a Mild Phenotype in the Smith-Lemli-Opitz Syndrome.

BACKGROUND: Smith-Lemli-Opitz syndrome (SLOS) is a common autosomal recessive disorder caused by pathogenic variants in the DHCR7 gene, resulting in a deficiency of the enzyme 7-dehydrocholesterol red...

METTL14 Regulates Adipose Tissue Macrophage Polarization via JAK2/STAT3 Pathway to Attenuate Obstructive Sleep Apnea-Related Systemic Inflammation.

The role of m6A RNA methylation in obstructive sleep apnea (OSA)-related metabolic dysfunction and systemic inflammation is unknown. We aimed to identify the key m6A regulator involved in OSA-induced ...

Curcumin Combined with Flaxseed Oil Modulates Lipid Metabolism in Hamsters Fed a High-Fat, High-Cholesterol Diet: Insights from Lipidomics.

Background/Objectives: Dyslipidemia and hepatic lipid buildup are key features of cardiometabolic disorders caused by high-fat, high-cholesterol diets. Both curcumin and flaxseed oil have been shown t...

A 35-Year-Old Woman With Recurrent Hypertriglyceridemia-Induced Pancreatitis in Pregnancy Managed With Fenofibrate and Plasmapheresis.

BACKGROUND Hypertriglyceridemia-induced pancreatitis in pregnancy is a rare condition that requires emergency management to prevent maternal morbidity and fetal loss. Physiological lipid shifts during...

Effect of Latilactobacillus curvatus HY7601 and Lactiplantibacillus plantarum KY1032 on Serum Triglyceride Levels and the Gut-Metabolic Axis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.

Background/Objectives: Hypertriglyceridemia is a critical cardiovascular risk factor, and the probiotic combination of Latilactobacillus curvatus HY7601 and Lactiplantibacillus plantarum KY1032 (HY+KY...

Pilot study of the use of ezetimibe in dogs with hyperlipidemia.

The aim of this study was to evaluate the tolerance and efficacy of ezetimibe in reducing cholesterol and/or triglycerides in dogs with hyperlipidemia. Twenty-three dogs with hyperlipidemia were rando...

Efficacy and safety of Ongericimab in patients with hypercholesterolemia: a systematic review and meta-analysis.

BACKGROUND: Hypercholesterolemia represents abnormally elevated cholesterol levels and constitutes a major modifiable risk factor for cardiovascular diseases (CVDs). Low-density lipoprotein cholestero...

Update on Investigation and Management of Dyslipidaemias and Cardiovascular Disease Risk.

Despite accounting for a quarter of all UK deaths, atherosclerotic cardiovascular disease (ASCVD) is frequently undertreated in non-specialist hospital care due to the perceived complexity of modern l...

[A case of acetaminophen-induced cholestatic liver injury accompanying severe hypercholesterolemia in children].

虽然对乙酰氨基酚（APAP）引起的肝损伤已有广泛报道，但关于APAP导致的严重高胆固醇血症的文献有限。现报道１例伴有严重高胆固醇血症的对乙酰氨基酚致胆汁淤积性肝损伤，在临床诊治中具有参考意义。.

Upper Arm to Upper Leg Length Ratio and Dyslipidemia: A Novel Application of a Fixed Skeletal Proportion Metric in a Nationally Representative U.S. Sample.

Conventional anthropometric measures used to predict dyslipidemia, such as body mass index and waist circumference, vary over time and may not fully capture early-life influences on metabolic risk. Fi...

Cystine: A Key Protective Factor Against Childhood Hypo-HDL Cholesterolemia and Dyslipidemia-A Matched Case-Control Study.

BACKGROUND: Dietary cystine may influence lipid metabolism, but epidemiological evidence in children is limited. This study aimed to investigate the association between dietary cystine intake and dysl...

[Mechanism of Buyang Huanwu Decoction and its different fractions in regulating cholesterol and treating hyperlipidemia].

This study aimed to explore the mechanisms of Buyang Huanwu Decoction(BYHWD) and its different fractions in treating hyperlipidemia, screen lipid-regulating active components, and optimize the formula...

[Effect and mechanism of Ligustrum robustum extract in intervening in lipid metabolism pathways to reduce lipid levels in hyperlipidemic mice].

To investigate the intervention effects of Ligustrum robustum extract(SLKDTE) on hyperlipidemia, a strategy combining transcriptomic analysis and experimental validation was employed. By administering...

[Traditional Chinese medicine understanding and treatment strategy of carotid atherosclerotic plaque with hyperlipidemia].

The prevalence of carotid atherosclerotic plaque and hyperlipidemia in China is high and continues to rise. Specifically, the incidence of hyperlipidemia among adults is 40.4%, and nearly one-third of...

[Ameliorating effect of Citri Reticulatae Pericarpium on hypercholesterolemia in rats through promoting reverse cholesterol transport].

This study aimed to elucidate the therapeutic potential and underlying mechanisms of the Citri Reticulatae Pericarpium extract(CRPE) against hypercholesterolemia. A hypercholesterolemic rat model was ...

Association Between PCSK9 Inhibitor Use and Risk of Age-Related Macular Degeneration.

PURPOSE: Age-related macular degeneration (AMD) has been linked to systemic lipid imbalance, vascular dysfunction, and inflammation. The ocular effects of proprotein convertase subtilisin/kexin type 9...

Functional Rice Enriched With Resistant Starch Ameliorates Metabolic Dysregulation in High-Fat Diet-Induced Obese Mice.

Resistant starch (RS) is a non-digestible fraction of dietary starch that modulates glucose and lipid metabolism. In this study, a RS-enriched high-amylose rice (R-HAR) was developed using a mild citr...

[Influenza virus infection affects the efficacy of the treatment of dyslipidemia in mice with a polyisoprenoid-based drug].

OBJECTIVE: To evaluate how influenza infection affects the hypolipidemic effect of a novel combined drug - Prenophytol based on polyisoprenoids (sodium polyprenyl phosphate and beta-sitosterol) in mic...

Barriers and Facilitators to the Use of Novel Injectable Lipid-Lowering Therapies in Patients with Dyslipidemia or Cardiovascular Disease: A Scoping Review.

Background/Aim: Cardiovascular disease (CVD) represents a relevant global public health challenge with dyslipidemia as a major modifiable cardiovascular risk factor (CVRF). Recent advances have introd...

Steroid use and lipid abnormalities in children: assessing the risk in chronic disease management.

Although steroid-induced dyslipidemia is well-documented in adults, its impact on children remains underexplored. Given the long-term cardiovascular risks associated with dyslipidemia, understanding i...