Pulmonary Arterial Hypertension Associated With Calcitonin Gene-Related Peptide Antagonist Therapy for Migraine: A Case Series.
Calcitonin gene-related peptide (CGRP)-targeted therapies are a recent addition to the migraine field. Monoclonal antibodies became available in 2018 and gepants in 2020, both now widely used for migr...
How ominous are persistent pain and hypertension for uncomplicated Type B aortic dissections?
An initial presentation of severe chest or back pain with uncontrolled hypertension in the absence of cardiac etiology is synonymous with aortic dissection. For aortic dissections that do not involve ...
Respiratory Management for the Infant with Congenital Diaphragmatic Hernia.
Congenital diaphragmatic hernia (CDH) is a complex neonatal condition characterized by pulmonary hypoplasia and pulmonary hypertension, requiring specialized ventilatory management from birth through ...
Plasma p-tau markers, vascular factors, and cognitive decline in the CIMA-Q cohort.
INTRODUCTION: We evaluated associations between phosphorylated au 217 (p-tau217), p-tau181, p-tau231, and vascular risk factors with cognitive outcomes across the Alzheimer's disease (AD) continuum. M...
The optimal blood pressure target in old and very old patients with hypertension.
BACKGROUND: With the rise in older population globally, the optimal blood pressure (BP) target for antihypertensive therapy in those aged 60 and above remains to be evaluated in the real-world practic...
Exposure Pattern Determines Methamphetamine-Induced Right Ventricular Dysfunction and Vascular Remodeling.
Methamphetamine (MA) use is a recognized risk factor for drug-associated pulmonary arterial hypertension (PAH), yet mechanisms driving methamphetamine-associated PAH (MA-PAH) remain unclear due to the...
Comparative Effectiveness and Safety of Three Oral Antihypertensive Therapies on Maternal and Infant Outcomes in a California Medicaid Population, 2016-2020.
PURPOSE: To extend the Chronic Hypertension and Pregnancy (CHAP) trial findings, this study compared labetalol, nifedipine, and methyldopa initiation at or before 23 weeks' gestation in pregnant patie...
Midlife hypertension and late-life cognition: weighting the LifeAfter90 study.
INTRODUCTION: Midlife hypertension is a well-established predictor of late-life cognitive decline; however, few population-representative estimates of this association exist among oldest-old cohorts. ...
Regional Variation of Aetiologies and Complications in Chronic Kidney Disease From Thailand (THAI-CKD Registry).
AIM: To investigate regional variations in Chronic Kidney Disease (CKD) aetiologies and complications across KDIGO risk strata in Thailand, aiming to optimise screening and monitoring in resource-cons...
Hypertension and altitude in community-dwelling older adults: an epidemiological study in northwest China.
OBJECTIVES: Hypertension is a major risk factor for cardiovascular and cerebrovascular diseases, and a relationship between altitude and hypertension has been demonstrated. To better characterise this...
Leveraging the Electronic Health Record to Identify and Manage Resistant Hypertension.
PURPOSE OF REVIEW: Resistant hypertension (RH) affects more than a tenth of adults and yet remains relatively underrecognized and undertreated. The electronic health record (EHR) now stands as a criti...
Fixed-Dose Combinations for Hypertension: Barriers to Use and Opportunities for Health Systems.
BACKGROUND: Uncontrolled hypertension is a leading driver of heart disease, chronic kidney disease, heart failure, dementia, stroke, and pregnancy-related complications. Fixed-dose combinations (FDCs)...
Estimated Pulse Wave Velocity Is Associated with Early Renal Impairment in Non-Diabetic Hypertensive Patients.
Hypertension is a major modifiable risk factor for chronic kidney disease (CKD), accelerating renal injury by promoting arterial stiffness. Estimated pulse wave velocity (ePWV), an indicator of arteri...
Influence of antihypertensive drug classes on circadian blood pressure patterns and left ventricular remodeling - a retrospective study.
BACKGROUND: Circadian blood pressure (BP) abnormalities, including nondipping and reverse-dipping patterns, are increasingly recognized as major determinants of cardiovascular target-organ damage, ind...
Associations of Long-Term Blood Pressure Burden and Variability With Kidney Function Decline.
Long-term blood pressure (BP) burden and visit-to-visit BP variability may better capture cumulative hemodynamic stress on the kidneys than single-visit BP measurements, yet evidence linking these met...
Impact of Reverse Dipper and Non-Dipper Blood Pressure Patterns on Myocardial Performance Index in Hypertensive Patients.
BACKGROUND: Abnormal nocturnal blood pressure patterns are associated with subclinical cardiac dysfunction in hypertension (HT). However, their relationship with the myocardial performance index (MPI)...
The Effect Modification of Systolic Blood Pressure on the Association of Frailty and Cardiovascular Disease in Community-Dwelling Adults.
Frailty has been increasingly recognized as an important predictor of cardiovascular disease (CVD) risk; however, the modifying role of systolic blood pressure (SBP) in this association remains unclea...
Pituitary Neurolobectomy induces sustained hypotension in male Wistar rats and normalizes blood pressure in male spontaneously hypertensive rats.
Arginine vasopressin is primarily recognized as an osmoregulatory hormone; however, its contribution to vascular tone and blood pressure regulation under basal and hypertensive conditions remains deba...
A Randomized Trial to Investigate the Effects of Low-Dose Colchicine in Patients with Hypertension: Rationale and Design of the COlchicine and HypERtENsion Trial (COHERENT).
Hypertension is a prevalent and significant risk factor for cardiovascular disease (CVD). The immune system and inflammatory response are involved in the pathophysiology of hypertension. We hypothesiz...
Left Ventricular and Left Atrial Mechanics in Resistant Hypertension-The Role of Two-Dimensional Speckle Tracking Echocardiography.
Resistant hypertension (RH) is associated with a high burden of cardiovascular morbidity and mortality. Early detection of subclinical myocardial dysfunction is essential for risk stratification and t...