Hypokalaemic paralysis as a presenting feature of primary aldosteronism.
A woman in her 30s presented with acute flaccid paraparesis secondary to severe hypokalaemia. She had a known history of hypertension controlled on amlodipine and bisoprolol. Biochemical workup reveal...
Association of intensive blood pressure lowering with health-related quality of life after endovascular thrombectomy: a post-hoc analysis of the ENCHANTED2/MT trial.
BACKGROUND AND PURPOSE: Intensive blood pressure (BP) targets of less than 120 mm Hg have been shown to worsen functional outcomes after endovascular thrombectomy (EVT) for acute ischemic stroke. Howe...
Tubular epithelial cells promote macrophage pyroptosis through PANX1-extracellular ATP-P2X7 signaling in aldosterone-dependent renal injury.
Tubular epithelial cell (TEC)-macrophage crosstalk contributes to aldosterone (Aldo)-dependent renal fibrosis in hypertension. Extracellular ATP (eATP) can act as a mediator of TEC-macrophage crosstal...
Suppression of Ephx2 in endothelial cells of penile cavernouse tissue improves SHR erectile function.
INTRODUCTION: Hypertension is a major cause of erectile dysfunction (ED). The impact of hypertension on the transcriptome and proteome of penile corpus cavernosum tissue, as well as its relationship w...
Safety and efficacy of lorundrostat, an aldosterone synthase inhibitor, in patients with uncontrolled hypertension: A systematic review and meta-analysis.
BACKGROUND: Limited data from randomized controlled trials (RCTs) indicate that lorundrostat, an aldosterone synthase inhibitor, may be effective in managing uncontrolled hypertension (HTN). Currently...
Association of antihypertensive drugs, intestinal ischemia, and breast diseases: A drug-target Mendelian Randomization study.
Both hypertensive and breast diseases impose a significant societal burden. However, the correlation between antihypertensive drug use and breast cancer remains controversial. We aimed to determine th...
Dietary Clusters and Mortality Risk in a Chinese Population: The Role of Type 2 Diabetes and Hypertension.
Background: Regional dietary variations in China are well-documented, but their mortality associations in local populations, particularly among individuals with type 2 diabetes (T2D) or hypertension, ...
Metabolic Syndrome: a Clinical Case Report and Literature Review.
BACKGROUND/AIMS: To present a clinical case of metabolic syndrome (MetS) and to provide a concise pathophysiological overview with emphasis on underlying metabolic and inflammatory mechanisms. METHODS...
Tianjin Health and Chronic Disease Study (THCDS): study design and baseline characteristics of the cohort - cohort profile.
PURPOSE: The Tianjin Health and Chronic Disease Study (THCDS) is a longitudinal dynamic cohort study established in 2022, aiming to investigate risk factors and intervention targets of common non-comm...
Primary Health Care approach to managing chronic kidney disease.
Chronic kidney disease (CKD) is a growing global health issue among ageing populations, driven by increasing diabetes and hypertension. Managing advanced stages of CKD with dialysis or transplants is ...
Detection of previously undiagnosed conditions in midlife preventive health examinations.
This study aimed to investigate the prevalence of previously undocumented suspected diagnoses identified during preventive health examinations in middle-aged adults, and to examine their associations ...
Agreement between various non-invasive blood pressure measurement sites in the obese population using the VitalStream system as control.
BACKGROUND: The incidence of obesity and hypertension, with all their associated complications, is on the rise globally. Non-invasive blood pressure (NIBP) is often difficult to measure in obese indiv...
Barriers for Secondary Hypertension Screening in the United States: A National Physician Survey.
BACKGROUND: Hypertension affects almost half of US adults and is a major cause of cardiovascular morbidity and mortality. Although expert guidelines recommend screening for secondary hypertension in p...
Aprocitentan: A New Option for Resistant Hypertension and Its Place in Patient Care.
Hypertension affects approximately 47.7% of US adults, with higher rates observed in men (50.8%) compared with women (44.6%). Risk factors and characteristics such as age, family history, race, and et...
ASSESSING THE EFFECTIVENESS OF LIFESTYLE CLINIC INTERVENTIONS ON CARDIOMETABOLIC RISK FACTORS: A RETROSPECTIVE STUDY.
BACKGROUND: Cardiometabolic disorders, including diabetes mellitus, hypertension, dyslipidemia, and obesity, represent a significant global health burden. While lifestyle interventions are recommended...
ASSESSMENT OF SUBCLINICAL RENAL INSULT IN SHORT- AND LONG-TERM UNCONTROLLED HYPERTENSION USING MOLECULAR BIOMARKERS OF NGAL AND KIM-1.
BACKGROUND: Uncontrolled Hypertension (UHTN) is a major cause of rapidly deteriorating kidney function. Typical clinical indicators often lack the sensitivity necessary for early detection of tubular ...
A Complex Case of Systemic Sclerosis with Concurrent Breast Malignancy and Treatment-related Complications.
Systemic sclerosis (SSc) is a complex autoimmune disease marked by vasculopathy, fibrosis, and multisystem involvement. Interstitial lung disease (ILD) and pulmonary hypertension (PH) are major mortal...
Ask-Upmark Kidney: A Rare Cause of Hypertension in Young Patients.
Ask-Upmark kidney was originally described as a congenital segmental hypoplasia of the kidney, but recent data suggest it to be a sequela of vesicoureteral reflux or pyelonephritis in early age. This ...
Structural model of health-promoting behavior in middle-aged Korean women with hypertension based on the Information-Motivation-Behavioral Skills model: a cross sectional study.
PURPOSE: This study aimed to develop and evaluate a hypothetical model of health-promoting behaviors among middle-aged women with hypertension, guided by the Information-Motivation-Behavioral Skills (...
Delivering Lifestyle Interventions for Chronic Disease Care Sustainably and at Scale through Virtual Shared Medical Appointments in Primary Care.
Behavior changes related to nutrition, physical activity, sleep, alcohol, and smoking are critical for the prevention and management of many chronic diseases, but interventions to implement these beha...