Warfarin Dose Adjustment During Rifampicin Therapy: A Case Report with Practical Monitoring Implications.
Warfarin management is challenging because its anticoagulant effect is influenced by drug-drug interactions and individual variability. Rifampicin is a potent inducer of cytochrome P450 enzymes and ca...
Community-Based Hypertension Screening to Prevent Stroke in Underserved Urban Neighborhoods in French Guiana: Protocol for a Quasi-Experimental Study.
BACKGROUND: Hypertension is a leading contributor to stroke and cardiovascular disease in underserved populations. OBJECTIVE: This study aims to evaluate a community-based hypertension screening inter...
[Primary aldosteronism in resistant hypertension unmasked by a thiazide-induced severe hypokalaemia].
Primary aldosteronism is the most common cause of secondary hypertension but remains frequently underdiagnosed in primary care. We report a 71-year-old man with resistant hypertension and low-normal s...
Occupational Physical Activity and Hypertension: A Narrative Review.
PURPOSE OF REVIEW: To summarize the prospective and experimental evidence examining occupational physical activity (OPA) and hypertension-related outcomes, discuss potential physiological mechanisms, ...
Bioinformatics and Machine-Learning Identification of Pulmonary Hypertension Biomarkers and Candidate Therapeutic Compounds.
This study aimed to identify pulmonary hypertension (PH)-associated molecular biomarkers and candidate small-molecule compounds using public transcriptomic data and independent validation resources. T...
Shoshin beriberi with severe lactic acidosis and haemodynamic collapse due to long-term diuretic therapy.
A patient on long-term diuretic treatment for pulmonary arterial hypertension presented with acute haemodynamic instability and profound high anion gap metabolic acidosis. Investigations showed severe...
Medication Non-Adherence in Resistant Hypertension: Detection, Drivers, and Practical Solutions.
PURPOSE OF REVIEW: Most patients with hypertension cannot reach goal blood pressure with lifestyle modification alone, so hypertension control relies heavily on patients taking medications as prescrib...
[Gastrointestinal metabolic surgery improves salt-sensitive hypertension via GLP-1-mediated inhibition of the RAS/NHE3 axis].
Objective: To investigate the effect of Roux-en-Y gastric bypass (RYGB) on salt-sensitive hypertension and its underlying molecular mechanism. Methods: (1) Clinical study: A total of 57 patients who u...
Hidden hypertension and early cardiac alterations: insights from ambulatory blood pressure monitoring in children and adolescents.
BACKGROUND: Hypertension is increasingly recognized as a significant health concern among children and adolescents, often associated with obesity and lifestyle choices. Early-onset hypertension can el...
[Perioperative outcomes and anesthetic management of pregnancy termination in patients with pulmonary hypertension].
OBJECTIVES: To investigate outcomes of pregnancy termination in women with pulmonary hypertension (PH) and the correlations of anesthetic management strategies and intraoperative blood pressure variab...
[Arterial hypertension and bronchial asthma: phenotype, cardiovascular complications, and independent predictors - an analysis of 57,396 patients from a hypertension registry].
BACKGROUND: The combination of arterial hypertension (AH) and bronchial asthma (BA) presents a complex clinical challenge that notably elevates cardiovascular risk. Real-world data are scarce regardin...
Persistent hypoxia with mosaic attenuation despite negative CT pulmonary angiography in chronic thromboembolic pulmonary hypertension.
Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare but serious complication of acute pulmonary embolism. It may be clinically silent and often presents with non-specific symptoms, making ...
Pendrin inhibitor PDSinh-C01 reverses salt-sensitive hypertension and metabolic acidosis in the 5/6 nephrectomy rat model.
Pharmacological inhibition of the chloride-bicarbonate exchanger pendrin with PDSinh-C01 potentiates the diuretic action of furosemide in healthy mice. Because pendrin contributes to acid-base regulat...
Effect of tirzepatide and semaglutide on blood pressure: A systematic review and meta-analysis.
PURPOSE: Tirzepatide and semaglutide are widely used for type 2 diabetes mellitus (T2DM) and obesity. However, the blood pressure-related adverse event profiles associated with tirzepatide and semaglu...
Lipoprotein(a) and Hypertension-Mediated Organ Damage in Patients with Essential Hypertension: Associations with Carotid Plaque and Impaired Nocturnal Blood Pressure Dipping.
Background and Objectives: Lipoprotein(a) [Lp(a)] is an established cardiovascular risk factor associated with atherosclerosis, vascular inflammation, and endothelial dysfunction. However, data regard...
Association Between Maternal Angiogenic Markers in Hypertensive Disorders of Pregnancy and Neonatal Growth and Body Composition.
Background/Objectives: Hypertensive disorders of pregnancy (HDPs) such as preeclampsia are associated with adverse maternal and perinatal outcomes and related to high soluble fms-like tyrosine kinase-...
Mechanistic Insights into the Antihypertensive and Cardioprotective Actions of Corosolic Acid: A Narrative Review.
BACKGROUND: The specific mechanisms underlying the antihypertensive actions of corosolic acid (CA) have not been systematically elucidated. METHODS: Evidence was categorized according to major signali...
Visceral Adiposity Is Independently Associated with Hypertension in Thai Adults: A Case-Control Study.
BACKGROUND: Hypertension is a major public health challenge and a leading contributor to cardiovascular morbidity and mortality worldwide. Although obesity is a well-established risk factor for hypert...
Global, regional, and national burden of chronic kidney disease attributable to dietary risks, 1990 to 2021: A systematic analysis for the Global Burden of Disease Study 2021.
Dietary risks are key modifiable contributors to chronic kidney disease (CKD) worldwide; however, their association with geographic or socioeconomic status remains underexplored. We aimed to quantify ...
Blood pressure and renal outcomes after renal denervation in patients with chronic kidney disease: A systematic review and meta-analysis.
BACKGROUND: This systematic review and meta-analysis aimed to evaluate the efficacy and safety of renal denervation (RDN) in patients with chronic kidney disease (CKD), including those with end-stage ...