The association between obesity indices and hypertension in adults with different glycemic status: A population-based cross-sectional study of the Bandare-Kong cohort.

Obesity and hypertension (HTN) frequently coexist with dysglycemia, yet it remains unclear whether general (BMI) versus central (waist circumference, WC) obesity indices show differential associations...

Trends in peripheral vascular disease-related mortality among U.S. adults with co-listed hypertension and type 2 diabetes, 1999-2023: A retrospective observational study.

Peripheral vascular disease (PVD) represents a major component of cardiovascular disease and is associated with substantial functional impairment and healthcare costs. However, long-term national tren...

Comparison of Labetalol With Versus Without Magnesium Sulfate on Intraoperative Blood Pressure Variability During Cesarean Delivery in Hypertensive Disorders of Pregnancy: A Retrospective Cohort Study.

AIM: This study aims to investigate the effects of two medication regimens-labetalol combined with magnesium sulfate versus labetalol alone-on intraoperative blood pressure variability (BPV) and mater...

Assessing quality gaps in hypertensive disorders of pregnancy care in China: an unannounced standardised patient study protocol.

BACKGROUND: Improving the quality of outpatient obstetric care is essential for achieving better maternal and perinatal outcomes, especially in resource-constrained settings. Despite guideline recomme...

Heterologous Expression, Antihypertensive Effect, and Underlying Mechanism of Sequence-Designed ACE Inhibitory Peptide YWLKP.

Rational sequence optimization is essential for transforming food-derived peptides into more potent angiotensin-converting enzyme (ACE) inhibitors. LYPVK and its sequence-designed derivative YWLKP exh...

[Early efficacy and safety of sotatercept in the treatment of pulmonary arterial hypertension in a Chinese population: a single-center case series analysis].

Objective: To preliminarily evaluate the efficacy and safety of sotatercept in patients with pulmonary arterial hypertension (PAH) in China. Methods: This single-center, retrospective case series anal...

Serum Angiopoietin-1 and Angiopoietin-2 as Biomarkers of Pulmonary Hemodynamic Burden in COPD-Associated Pulmonary Hypertension: A Cross-Sectional Study.

Purpose: Pulmonary hypertension (PH) is a serious complication of COPD associated with worse outcomes. Reliable circulating biomarkers of pulmonary vascular involvement are lacking. Angiopoietin-1 (AN...

Practice nurse management of hypertension in primary care: a scoping review.

AIM: To review the current diagnosis and treatment of hypertension (HTN) and explore alternative care management options. BACKGROUND: HTN is underdiagnosed and poorly managed in the UK. With an increa...

Visit-to-Visit Blood Pressure Variability and Cerebral White Matter Lesion Progression: A Pooled Individual Patient Data Analysis of 2 Trials.

BACKGROUND AND OBJECTIVES: Visit-to-visit blood pressure variability (BPV) may contribute to cerebral white matter lesions (WML) progression, but previous evidence has been inconsistent and limited by...

Ultra-Processed Food-Rich Dietary Proxies, Dietary-Pattern Context, and Cardiometabolic Outcomes in Spain: Weighted Evidence Consistent with Age Confounding and Possible Reverse-Causality Bias from the 2023 Spanish Health Survey.

BACKGROUND/OBJECTIVES: Ultra-processed foods (UPFs) are linked to cardiometabolic disease, but cross-sectional surveys often underestimate or invert these associations due to age structure, diagnosis-...

Validation of Self-Reported Disease History in Korea: A National Health Insurance Cohort Study.

BACKGROUND: Self-reported disease history is widely used in epidemiological studies but is susceptible to misclassification. This study aimed to evaluate the accuracy of self-reported history of hyper...

The MILEPOST Framework for Integrating mHealth Into Community-Driven Interventions: Lessons Learned From a Human-Centered Design Approach in Rural Uganda.

Participatory design approaches to develop global health interventions have gained traction in recent years. However, while broad frameworks for the application of design approaches exist, literature ...

Longitudinal progression of tissue remodeling in experimental pulmonary hypertension is accompanied by a continuously increasing re-expression of extra domain A-containing fibronectin.

Pulmonary hypertension (PH) is a progressive disease characterized by pulmonary vascular remodeling and increasing right ventricular (RV) afterload. Extracellular matrix (ECM) remodeling is central to...

Bibliometrics and Bioinformatics Exploration of Research Hotspots and Key Targets in Comorbidity: Interstitial Lung Disease and Pulmonary Hypertension.

Interstitial lung disease (ILD) and pulmonary hypertension (PH) frequently coexist as comorbidities, leading to poor clinical outcomes and limited therapeutic options. Identifying important research h...

Analysis of demographic and clinical characteristics of patients with chronic renal failure in Mosul City, Iraq.

AIM: To assess demographic and clinical determinants of CKD among patients undergoing haemodialysis in Mosul, Iraq. METHODS: A descriptive cross-sectional study was conducted at a public dialysis cent...

Analysis of the effects of heat-not-burn tobacco product use on cardiorespiratory symptoms in adults.

AIM: To determine if heat-not-burn (HNB) tobacco products are a safe alternative to cigarette smoking by inducing decreased decline of cardiorespiratory function. METHODS: A clinical observational, cr...

STOP-RIO study: protocol for a randomised, controlled, open-label non-inferiority trial to test the safety of discontinuation of riociguat after balloon pulmonary angioplasty in chronic thromboembolic pulmonary hypertension.

INTRODUCTION: Balloon pulmonary angioplasty (BPA) improves haemodynamics and outcomes in patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH). Riociguat is frequently initiat...

Development and validation of a nomogram prediction model for mild pulmonary arterial hypertension risk in children with left-to-right shunt congenital heart disease.

Mild pulmonary arterial hypertension (PAH) represents an early and potentially reversible complication stage in children with congenital structural heart disease (CHD). Early identification of high-ri...

Identification of novel loci regulating circulating melatonin and its causal relationship with hypertension.

Melatonin exerts pleiotropic physiological functions and diverse disease associations, but its genetic architecture remains largely uncharacterized. Using low-coverage whole-genome sequencing (lcWGS) ...

Association of non-conventional lipid-inflammatory parameters with incident hypertension risk: a prospective cohort study.

BACKGROUND: Emerging research has associated non-conventional lipid indices with hypertension risk; however, the joint contribution of these lipid metrics and inflammatory biomarkers to hypertension s...