Navigating the Complexity of PH-ILD: From Molecular Mechanisms to Integrated Clinical Evaluation.

Pulmonary Hypertension (PH) in patients with Interstitial Lung Disease (ILD) is a critical, yet underrecognized, complication that affects patients' quality of life and increases mortality. Emerging e...

Distinctive mortality patterns and the survival paradox in intracerebral haemorrhage subtypes: a 15-year longitudinal study.

INTRODUCTION: We investigated long-term outcomes, survival trajectories and cause-specific mortality in intracerebral haemorrhage (ICH) subtypes stratified by aetiology, location and recurrence status...

Association Between Maternal Protein Intake and the Risk of Adverse Pregnancy Outcomes.

Background/Objectives: This study examined the association between low protein intake and pregnancy outcomes to test whether low protein intake was associated with higher rates of small for gestationa...

Systemic Comorbidities in Central Centrifugal Cicatricial Alopecia: A Systematic Review and Meta-analysis.

Central centrifugal cicatricial alopecia (CCCA) is the most common scarring alopecia among women of African descent and has been increasingly associated with systemic comorbidities, particularly cardi...

Hypertension Incidence and Blood Pressure Control in Hispanic or Latino Adults in the HCHS/SOL Study.

IMPORTANCE: Among US Hispanic or Latino adults, the burden of hypertension is high, with substantial variation by heritage group. The long-term incidence of hypertension and prevalence of blood pressu...

Exceptional Parental Longevity and Onset of Morbidity and Mortality Across Cohorts.

IMPORTANCE: Centenarian lifespan extension is frequently accompanied by delayed onset of aging-associated diseases. Understanding the transgenerational patterns of this phenomenon is crucial for infor...

Care Navigation, Self-Measured Blood Pressure, and Health Coaching for Postpartum Care: A Randomized Clinical Trial.

IMPORTANCE: Hypertensive disorders of pregnancy (HDP) affect 10% to 16% of US pregnancies and increase the risk of developing cardiovascular disease. Guidelines recommend that individuals who experien...

Upregulated Renal Mineralocorticoid Receptor and 11β-Hydroxysteroid Dehydrogenase Type 2 Are Associated with K(+) Retention During MR Antagonism in Female Spontaneously Hypertensive Rats.

Mineralocorticoid receptor (MR) blockade exerts sex-specific effects in hypertension and cardiovascular disease; however, its role in blood pressure regulation in spontaneously hypertensive rats (SHRs...

[Construction of a risk prediction model for vascular function damage in children with primary hypertension].

Objective: To investigate the risk factors of vascular function damage in children with primary hypertension and establish a risk prediction model. Methods: In this retrospective case-control study, a...

Comparison of Oral and Intravenous Nitroglycerin in the Treatment of Acute Postpartum Hypertension After Cesarean Delivery for Preeclampsia.

BACKGROUND: Acute postpartum hypertension is common among women with preeclampsia, particularly after cesarean delivery, and is traditionally managed with intravenous (IV) antihypertensive agents. How...

Gender-based Assessment of Cardiovascular Risk Factors among Young Hypertensives in a Tertiary Hospital in Southwestern Nigeria: A Cross-sectional Study.

BACKGROUND: Gender variation exists in the clustering of cardiovascular (CV) risk factors. Hypertension (HTN), diabetes mellitus (DM), lipid abnormalities, obesity, cigarette smoking, and significant ...

Modeling chronic kidney disease progression using a continuous-time multistate Markov model: Transition dynamics and covariate effects.

Chronic kidney disease is a progressive condition that impairs renal function and can ultimately lead to kidney failure. Its progression involves multiple intermediate stages, making conventional surv...

Blood Pressure and Systemic Risk Factors in Patients Presenting With Post-Extraction and Periodontal Bleeding at a Dental Out-of-Hours Clinic.

OBJECTIVE: This study aimed to verify whether blood pressure was higher in patients presenting to the dental out-of-hours clinic with post-extraction bleeding (PEB) and periodontal disease-related gin...

Endothelin Receptor Antagonists in Resistant Hypertension and Proteinuric Kidney Disease: Receptor Strategy and Volume Management.

This narrative review examines how endothelin receptor antagonists (ERAs) can be used at the intersection of difficult-to-control hypertension, chronic kidney disease (CKD), and albuminuria or protein...

Case 353.

History An 8-month-old term-born female infant presented to the pediatric emergency department with progressively increasing respiratory distress and episodic hypoxic spells for 2 months. Antenatal an...

Antihypertensive effect of acupuncture involve reshaping gut microbiota and alleviating gut inflammation in spontaneously hypertensive rats.

OBJECTIVE: To investigate the antihypertensive effect and mechanism of acupuncture at Renying (ST9) and Zusanli (ST36) from the perspective of gut microbiota. METHODS: Eighteen male spontaneously hype...

Temporal Trends in Preterm Birth Associated With Hypertensive Disorders of Pregnancy in Victoria, Australia: A Population-Based Interrupted Time-Series Study.

OBJECTIVES: Hypertensive disorders of pregnancy (HDP) are a leading reason for medically indicated preterm birth (PTB), yet their contribution to population-level PTB trends is poorly understood. We e...

Phenotype-Dependent Effect of Bedtime Antihypertensive Dosing on Nocturnal Blood Pressure: A Meta-Analysis Guided by Non-Dipper Prevalence.

Bedtime dosing of antihypertensive medications is associated with a reduction in nocturnal blood pressure (BP), but whether this effect is modified at the study level remains uncertain. We conducted a...

Renin-Angiotensin System Inhibitor Use and Mortality in Older Hypertensive Patients With and Without Dementia: A Nationwide Registry-Based Cohort Study.

Cardiovascular risk factors are often undertreated in patients with dementia. Renin-angiotensin system inhibitors (RASI) are first-line treatments for hypertension. We examined the association between...

Twenty-Four-Hour Blood Pressure Variability Combined With Circadian Rhythm Patterns in Predicting Cardiovascular Events in Hypertensive Patients.

Short-term blood pressure variability (BPV) and circadian BP abnormalities are important cardiovascular risk predictors of mean BP levels, but their combined prognostic significance in essential hyper...