Vascular smooth muscle cells (VSMCs) play a central role in atherosclerosis by undergoing phenotypic modulation from a quiescent, contractile state to a range of synthetic phenotypes, including fibrob...
Vascular smooth muscle cells (VSMCs) play a central role in atherosclerosis by undergoing phenotypic modulation from a quiescent, contractile state to a range of synthetic phenotypes, including fibrob...
Cardiac fibrosis is a major cause of cardiac dysfunction and is associated with virtually all forms of heart disease. Recently, single-cell genomic approaches have revealed in unprecedented resolution...
SIRT1 (sirtuin 1), a nicotinamide adenine dinucleotide-dependent protein deacetylase, regulates cardiovascular inflammation by modulating cellular stress, inhibiting NLRP3 (NLR family, pyrin domain-co...
Thrombosis is a major contributor to morbidity and mortality in cardiovascular diseases. Although current antiplatelet therapies reduce thrombotic complications, they are associated with systemic blee...
Macrophages are key players in the pathogenesis of atherosclerosis. They trigger immune responses through their cell-surface receptors. However, how macrophages regulate those receptors in response to...
Protocolos Nacionales de Atención Médica: marco para fortalecer la atención de primer nivel en México.
OBJETIVO: Describir el proceso de desarrollo y las características principales de los Protocolos Nacionales de Atención Médica (PRONAM), una estrategia nacional para estandarizar la práctica clínica e...
Myocardial Injury in Rheumatic Diseases: Immune and Microcirculatory and Molecular Mechanisms of Cardiomyopathies.
Immune-mediated myocardial injury is an important yet underrecognized manifestation of systemic rheumatic diseases and represents a biologically heterogeneous process extending beyond traditional card...
Selective Alterations of Thiol Redox Homeostasis and Antioxidant Enzyme Activity in Advanced Atherosclerosis.
Atherosclerosis is a progressive vascular disease characterized by lipid-rich plaque accumulation, oxidative stress, and chronic inflammation, contributing to coronary heart disease, stroke, and perip...
Tenascin-C Drives Inflammatory VSMC Phenotypic Switching Through NF-κB Signaling in Saphenous Vein Graft Restenosis.
Vein graft restenosis is a leading cause of long-term failure after coronary artery bypass grafting (CABG), driven by maladaptive vascular smooth muscle cell (VSMC) responses to arterialization-induce...
Long-term impact of haemorrhoidal artery ligation on anal function and continence.
AIMS: Haemorrhoidal artery ligation (HALO) and variants including Doppler-guided HAL (DG-HAL), HAL with rectoanal repair (HAL-RAR), and transanal haemorrhoidal dearterialisation (THD) serve as minimal...
The emerging role of the meningeal lymphatic and glymphatic systems in migraine pathophysiology: a systematic review.
BACKGROUND/OBJECTIVE: Migraine is a common, debilitating neurological disorder of unclear pathophysiology. Recent evidence has implicated impaired meningeal lymphatic function and its interaction with...
Cost-effectiveness-oriented management (CEOM) of cardiovascular risks at primary healthcare settings in Anhui, China: a protocol for a cluster randomised controlled trial.
INTRODUCTION: Cardiovascular disease (CVD) represents a significant health and economic burden in China. Despite extensive research on CVD management in primary care, the cost-effectiveness of current...
AMI-SSS01 portable phonocardiographic examination with AI-assisted assessment for detecting heart failure exacerbations in home-based medical care in Japanese primary care clinics: a study protocol for a randomised controlled feasibility trial.
INTRODUCTION: The global prevalence of heart failure continues to increase, particularly in ageing populations. Many older patients receiving home-based medical care have limited access to standard di...
CFD-driven optimization and experimental validation of venturi-based thrombectomy devices in a circle of willis.
The geometry of the Circle of Willis poses major challenges for mechanical thrombectomy, where device navigability and effective thrombus removal determine treatment success. This study investigated t...
A Systematic Review of Modeling Platforms for Atrioventricular Valves in Atrioventricular Septal Defects.
Given the high rate of re-intervention in patients with atrioventricular septal defects (AVSD), there is a continuing need to accurately model the complex valve anatomy and surgical repair strategies....
Intra-arterial thrombolysis as adjunct to endovascular treatment in acute basilar artery occlusion.
BACKGROUND AND PURPOSE: Evidence for intra-arterial thrombolysis (IAT) after endovascular treatment (EVT) remains limited in acute basilar artery occlusion (ABAO), particularly among patients with suc...
Left ventricular mechanical dispersion in a middle-aged population: associations with subclinical cardiac remodelling and cardiovascular risk.
BACKGROUND: Heterogeneous myocardial contraction is common in myocardial disease and linked to ventricular arrhythmias, but its frequency and relevance in the general population remain unclear. This s...
Single-cell Technologies in Atherosclerosis: Uncovering Cellular Heterogeneity, Mechanisms, and Therapeutic Opportunities.
PURPOSE OF REVIEW: This review highlights recent advances in single-cell analysis technologies and their application in clarifying the cellular and molecular complexity of atherosclerosis, redefining ...
Microglia-driven neuroinflammatory signaling in neurodegeneration: mechanisms and therapeutic opportunities.
Neuroinflammation has been identified as a major component to the pathogenesis and progression of many neurodegenerative illnesses, going beyond its traditional role as a protective immune response wi...
Evaluation of 3D-CRT vs. VMAT for radiotherapy of whole breast with simultaneous integrated boost.
BACKGROUND AND PURPOSE: This study evaluates volumetric modulated arc therapy (VMAT) as a potential alternative to three-dimensional conformal radiotherapy (3D-CRT) for whole-breast radiotherapy (RT) ...