Impact of Regional Hepatic Immunosuppression With Budesonide on Bacterial Elimination in Porcine Abdominal Sepsis.

INTRODUCTION: The liver is essential for bacterial elimination, preventing intestinal bacteria from entering the systemic circulation, and for producing inflammatory cytokines. Glucocorticoids have be...

Device Management of Patients on Left Ventricular Assist Device Support: A Practical Review for the ICU Clinician.

Nonphysiologic continuous flow (cf) in the current era of left ventricular assist device (LVAD) support confers unique challenges in management, with greater preload/afterload sensitivity, reduced sys...

The Left Ventricular Assist Device Patient in the Intensive Care Unit: A Clinically Focused Guide for Intensivists.

Left ventricular assist devices (LVADs) are increasingly used for advanced heart failure patients. Meanwhile, ongoing improvements in durability have enhanced long-term device performance. Intensivist...

Permanent Left Ventricular Assist Devices: Long-Term Management and Outcomes.

This article outlines the historical development, physiologic principles, and contemporary clinical management of durable left ventricular assist devices, with a primary focus on the HeartMate 3 era. ...

Temporary Left Ventricular Assist Devices: Indications and Patient Selection.

Temporary percutaneous left ventricular assist devices (pLVADs), most prominently transvalvular microaxial flow pumps, have become central tools for contemporary cardiogenic shock care and for hemodyn...

Optimizing Mechanical Ventilation in Right Heart Failure.

In patients with acute respiratory distress syndrome, the prevalence of right ventricular dysfunction (RVD) has been documented as high as 60%, though more recent estimates suggest a lower incidence o...

Concurrent Four-Dimensional Dynamic MRA and Perfusion Imaging Using Dual-Module Arterial Spin Labeling MRI With Stack-Of-Stars Golden-Angle Radial Acquisition.

Arterial spin labeling (ASL) has been used for perfusion imaging and non-contrast enhanced dynamic MR angiography (MRA), and both have become favorable for clinical diagnosis and treatment planning of...

VesMamba: Vessel Morphology-Enhanced State Space Model for Cerebrovascular Delineation.

Accurate delineation of cerebrovascular structures from Time-Of-Flight Magnetic Resonance Angiography (TOF-MRA) and Computed Tomography Angiography (CTA) is essential for the clinical diagnosis and tr...

PCSK9 alleviates doxorubicin‑induced pyroptosis of cardiomyocytes.

Prolonged survival of patients with cancer has increased the need to address chemotherapy‑related cardiovascular complications. Doxorubicin (DOX), a widely used anthracycline, is associated with dose‑...

From cell to disease: Regulatory networks and mechanisms of super‑enhancers in aging (Review).

Aging is accompanied by a gradual loss of cellular function and systemic weakening of the homeostasis of multiple tissues, leading to a variety of age‑related diseases and eventual mortality. Super‑en...

In Vivo Ultrasound Characterization of the Tibial Nerve at the Supramalleolar Region.

BACKGROUND: Accurate knowledge of the supramalleolar anatomy of the tibial nerve is essential for safe ultrasound-guided procedures and proximal nerve interventions in the foot and ankle. However, qua...

Study on retinal pharmacokinetic characteristics and precision drug administration strategy in patients with fundus diseases.

BACKGROUND: Fundus diseases are major causes of irreversible visual impairment. Retinal pharmacokinetic behavior may differ between diabetic retinopathy (DR) and age-related macular degeneration (AMD)...

Bioactive phytochemicals of jasmine oil and their role in managing hypertension: A combined clinical and in-silico study.

BACKGROUND: Jasmine oil massage has a thousand years of traditional history of curing and treating various ailments like hypertension, diabetes and muscle cramps without any sound pharmacological evid...

Effect of diltiazem sustained-release capsules on cardiorenal composite outcomes in hypertensive patients with coronary heart disease: A real-world propensity score-matched study.

BACKGROUND: Hypertension frequently coexists with coronary heart disease (CHD) and integrated management is essential to reduce cardiovascular and renal complications. OBJECTIVES: To evaluate the effi...

Jianxin granules enhance autophagic flux and reduce apoptosis in heart failure via mTOR pathway: A preclinical investigation.

BACKGROUND: Heart failure (HF) is a leading cardiovascular disease worldwide. Jianxin Granule, a traditional Chinese medicine formula, has been clinically shown to improve cardiac function, yet its mo...

Correlation study of serum vitamin K and Gas6 levels with aortic arch calcification and left ventricular hypertrophy in maintenance hemodialysis patients.

BACKGROUND: Cardiovascular disease is the leading cause of death among MHD patients, with aortic arch calcification and left ventricular hypertrophy as common complications. The role of vitamin K-depe...

A dyadic reminiscence intervention on mutuality for persons with heart failure and their spouse caregivers: A quasi-experimental study.

OBJECTIVE: Low mutuality between persons with heart failure (HF) and their spouse caregivers is associated with adverse outcomes in the dyads. However, dyadic interventions targeting enhanced mutualit...

Hearing Loss and Modifiable Dementia Risk Factors in Adults Aged 50 Years or Older Living in Tasmania, Australia.

OBJECTIVE: This study examined the associations between hearing loss (HL) and other modifiable dementia risk factors in adults aged 50 years or older living in Tasmania and explored the effects of cor...

Endothelial dysfunction: A central mechanism linking autosomal dominant polycystic kidney disease and intracranial aneurysms (Review).

Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disorder and is characterized by the progressive development of multiple bilateral renal cysts and the deterio...

Lecture-First Versus Practical-First Teaching Strategies in Cardiovascular Ultrasound Education: A Randomized Comparison of Undergraduate Performance.

Cardiovascular ultrasound is an operator-dependent modality that requires careful sequencing of the theoretical and practical training to optimize skills acquisition. This study compares lecture-first...