A 33-Year Old with Wide Complex Tachycardia.
A 33-year-old woman presented to the emergency department (ED) with dizziness and palpitations and was found to be in wide complex tachycardia. EP study the following day showed consistent pre-excitat...
A 33-Year Old with Wide Complex Tachycardia.
A 33-year-old woman presented to the emergency department (ED) with dizziness and palpitations and was found to be in wide complex tachycardia. EP study the following day showed consistent pre-excitat...
Bachmann Bundle Pacing Combined with ICD in Hypertrophic Cardiomyopathy with Interatrial Conduction Block.
This case presents a 67-year-old man with familial hypertrophic cardiomyopathy, severe heart failure (LVEF 31%, NYHA III), and significant interatrial conduction delay. After ruling out cardiac resync...
Atrial Arrhythmia Following Extra-cardiac Fontan Surgery: Is the Arrhythmia Mechanism Characterized?
We discuss a case of symptomatic atrial arrhythmia in a 31 year old man who had previously undergone extra-cardiac Fontan surgery and a MAZE procedure. Besides the peculiar anatomy that restricted per...
Ventricular Tachycardia Ablation in a Case of Calcified Left Ventricular Apical Aneurysm.
Calcific left ventricular (LV) apical aneurysms represent a highly arrhythmogenic substrate for ventricular tachycardias (VTs), posing unique challenges for mapping and catheter ablation. Dense calcif...
Electrophysiological Insights in a Successful Cavotricuspid Isthmus Ablation of an Atypical Denovo Single-Loop Clockwise Epicardial Biatrial Flutter.
Biatrial macro-reentrant tachycardias are rare in patients without prior atrial intervention and often pose diagnostic and therapeutic challenges. We present a case of de novo single-loop biatrial flu...
Successful Epicardial Ablation of a Right Infero-paraseptal Accessory Pathway Presenting as Ventricular Fibrillation.
A 22-year-old man presented with aborted sudden cardiac arrest due to ventricular fibrillation and recurrent tachyarrhythmia related to a right inferoparaseptal accessory pathway. A previous electroph...
Cardiac Opioid System and Its Role in Heart Failure and Ischemia-Reperfusion Injury.
Opioid receptors and peptides act as modulators of cardiac and vascular function. These effects are mediated not only by central mechanisms but also via a local cardiac opioid system, which has gained...
Effects of Nurse-Led Interventions on Quality of Life and Self-Care Among Patients With Heart Failure: A Systematic Review.
BACKGROUND: Nurses are pivotal in promoting self-care among patients with heart failure (HF), particularly by educating them on how to prevent potential complications and rehospitalisations. Meanwhile...
Dynamic Risk Assessment for the Development of Persistent Atrial Fibrillation Using Statistical and Machine Learning Approaches.
BACKGROUND: Cardiac implantable electronic devices (CIEDs) frequently detect brief, often subclinical atrial fibrillation (AF), but their value for predicting progression to persistent AF remains unce...
High-Protein Diet Ameliorates Cardiomyopathy in a Cardiac-Specific AGL Knockout Mouse Model: Association With Upregulated Hepatic Gluconeogenesis.
Glycogen storage disease type IIIa (GSDIIIa) causes progressive cardiomyopathy, and current high-fat dietary strategies lack consensus regarding long-term cardiovascular safety. We evaluated the effic...
Proteomic Remodeling in the Failing Left Ventricle Adapting to Dyssynchrony.
PURPOSE: In heart failure, dyssynchrony is associated with accelerated cardiac remodeling and a worse prognosis. Both restored with resynchronization. We have previously developed a mouse model of dys...
Which Is Preferable for Chronic Limb-threatening Ischemia: Bypass versus Endovascular Therapy?
Chronic limb-threatening ischemia is the most advanced stage of peripheral arterial disease and typically requires revascularization to prevent limb-loss. The choice of open surgical bypass versus end...
Pharmacologic Options for Treatment and Prevention of Hypertensive Disorders of Pregnancy.
Hypertensive disorders affect 15% of US pregnancies, significantly contributing to maternal and neonatal morbidity. This paper explores the profound hemodynamic adaptations of pregnancy and how their ...
Computed Tomography-Based Anatomical and Morphometric Analysis of the Left and Right Gastric Arteries in a Vietnamese Population.
Anatomical variations of the left gastric artery (LGA) and right gastric artery (RGA) are clinically relevant for gastric surgery and endovascular interventions. This study aimed to characterize the o...
Association Between Socioeconomic Status and Atrial Fibrillation: A Two-Sample Mendelian Randomization Study.
BACKGROUND: Lower socioeconomic status (SES), reflected by greater socioeconomic deprivation, lower household income, and lower educational attainment (EA), has been associated with atrial fibrillatio...
Anti-Müllerian Hormone and Metabolic-Hormonal Profiles in Women With and Without Polycystic Ovary Syndrome: A Population-Based Study.
INTRODUCTION: Evidence regarding age-related variation in anti-Müllerian hormone (AMH) and its associations with hormonal and metabolic parameters in women with polycystic ovary syndrome (PCOS), healt...
Tirzepatide and SGLT2 Inhibitors for Heart Failure With Preserved Ejection Fraction and Obesity: Entering a New Cardiometabolic Therapeutic Era.
BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) accounts for over half of all heart failure hospitalizations, with obesity increasingly recognized as a central driver through expans...
Beyond Glycemia in T1D: The Hidden Burden of Insulin Resistance and Cardiorenal Risk in Type 1 Diabetes-Part 1.
Insulin resistance (IR) is an underrecognized feature of type 1 diabetes (T1D), present even in lean individuals. Rising obesity rates have further amplified this burden, creating a mixed metabolic ph...
Effects of Hedan Tablets Combined With Simvastatin on Hyperlipidemia: Insights From Microbiomics and Metabolomics.
Simvastatin (ST) has limited long-term clinical utility due to its adverse effects. The combination of Hedan tablets and simvastatin (HST) exhibits superior lipid-lowering effects, but its mechanism r...
Chronic kidney disease‑associated encephalopathy: Clinical features, pathomechanisms and emerging therapeutic strategies (Review).
Chronic kidney disease (CKD) is a progressive disorder whose systemic effects extend to the central nervous system, leading to CKD‑associated encephalopathy. Epidemiological data indicate that the pre...