Clinical Outcomes Following PM Implantation: A 3-Year Comparative Study of Sick Sinus Syndrome and Atrioventricular Block.

BACKGROUND: Permanent pacemaker implantation is an established treatment for both sick sinus syndrome (SSS) and atrioventricular block (AVB), yet limited data exist comparing long-term clinical outcom...

Coronary Artery Calcium Score, Risk Factors, and Clinical Outcomes in Nonobstructive Coronary Artery Disease: A Long-Term Follow-Up Study.

BACKGROUND: The prognostic value of coronary artery calcium (CAC) score in nonobstructive coronary artery disease (NObCAD; stenosis < 50%) remains insufficiently characterized. OBJECTIVES: To investig...

Occupational Noise Exposure Assessed by High-Frequency Hearing Loss and its Association with Hypertension among Air Force Ground Staff.

OBJECTIVE: This study aimed to examine the association between cumulative occupational noise exposure, using high-frequency hearing loss as an objective marker, and hypertension among Air Force ground...

Self-testing and clinical outcomes in Black and White patients on warfarin for atrial fibrillation or venous thromboembolism.

BACKGROUND: Warfarin management requires frequent international normalized ratio (INR) testing. Self-testing may reduce this burden and improve INR control and outcomes. However, concerns exist about ...

[Effect of community-based intensive smoking cessation intervention on smoking behavior and blood pressure control in hypertensive patients].

OBJECTIVE: To evaluate the effectiveness of an intensive community-based smoking cessation intervention on smoking behavior and blood pressure control among patients with hypertension. METHODS: A clus...

[Association between the trajectory of body mass index and elevated blood pressure in children: a cohort study from 2013 to 2024].

OBJECTIVE: To characterize the longitudinal trajectories of body-mass-index-for-age Z-score(BAZ) from birth to 7-9 years and to explore their association with elevated blood pressure(EBP) in childhood...

[Mechanism of Buyang Huanwu Decoction and its different fractions in regulating cholesterol and treating hyperlipidemia].

This study aimed to explore the mechanisms of Buyang Huanwu Decoction(BYHWD) and its different fractions in treating hyperlipidemia, screen lipid-regulating active components, and optimize the formula...

[Effect and mechanism of Ligustrum robustum extract in intervening in lipid metabolism pathways to reduce lipid levels in hyperlipidemic mice].

To investigate the intervention effects of Ligustrum robustum extract(SLKDTE) on hyperlipidemia, a strategy combining transcriptomic analysis and experimental validation was employed. By administering...

[Traditional Chinese medicine understanding and treatment strategy of carotid atherosclerotic plaque with hyperlipidemia].

The prevalence of carotid atherosclerotic plaque and hyperlipidemia in China is high and continues to rise. Specifically, the incidence of hyperlipidemia among adults is 40.4%, and nearly one-third of...

[Ameliorating effect of Citri Reticulatae Pericarpium on hypercholesterolemia in rats through promoting reverse cholesterol transport].

This study aimed to elucidate the therapeutic potential and underlying mechanisms of the Citri Reticulatae Pericarpium extract(CRPE) against hypercholesterolemia. A hypercholesterolemic rat model was ...

[Junren Bufei Yixin Granules ameliorates hypoxic pulmonary hypertension by regulating RELM-β/SLC7A11/GPX4 signaling pathway].

This study aims to investigate the ameliorative effect of Junren Bufei Yixin Granules( JRBF) on hypoxic pulmonary hypertension(HPH) and its regulatory mechanism on the resistin like molecule-β( RELM-β...

[Analysis of simultaneous heart-lung treatment strategy for chronic obstructive pulmonary disease complicated with coronary heart disease based on blood turbidity theory].

The comorbidity of chronic obstructive pulmonary disease(COPD) and coronary heart disease(CHD) is becoming increasingly common. These conditions exacerbate each other through multiple mechanisms such ...

[Metabolomics and metagenomics reveal mechanism of Xinglou Chengqi Decoction in preventing cerebral ischemia-reperfusion injury].

This study uses a rat model of middle cerebral artery occlusion and reperfusion(MCAO/R) to investigate the mechanism by which Xinglou Chengqi Decoction treats cerebral ischemia-reperfusion injury, emp...

[Heart-brain interaction: mechanisms and therapeutic strategies from integrated TCM and western medicine].

Cardiovascular and cerebrovascular diseases have a high global incidence and are major causes of disability and mortality. This review integrates perspectives from both TCM and modern medicine. Based ...

[Integrating network pharmacology and transcriptomics to reveal mechanism of loganin in ameliorating isoprenaline-induced myocardial injury].

This study employed an integrated strategy combining network pharmacology, transcriptome sequencing, molecular docking, and in vivo and in vitro experimental validation to systematically investigate t...

[Efficacy and mechanism of Xiaoxuming Decoction on neurological function impairment in mice with cerebral ischemia-reperfusion based on metabolomics].

This study aimed to investigate the neuroprotective effects and potential mechanism of Xiaoxuming Decoction(XXM) against cerebral ischemia-reperfusion injury in mice. The middle cerebral artery occlus...

Twenty-Year Follow-up After Combined Heart and Kidney Transplant: A Case Report.

Combined heart and kidney transplant is a rare but valuable treatment option for selected patients with end -stage cardiac and renal failure. We present the long -term outcome of a 27 -year -old man w...

Fibrin Hydrogel Containing Microvascular Fragments for Improving Subcutaneous Islet Transplants in Diabetic Rats.

OBJECTIVES: Subcutaneous tissue serves as a noninvasive and easily accessible site for pancreatic islets transplant; however, poor blood supply impedes survival of pancreatic islet cells and increases...

Assessment of Recipient Renal Transplant Arterial Graft Supply in the Immediate Postoperative Period (≤1 week): A Systematic Review.

OBJECTIVES: Early detection of renal allograft complications can prompt immediate treatment to preserve graft function. Radiological evaluation of allograft vascular supply can be achieved with the us...

Rare stability in dogs with myxomatous mitral valve disease: Clinical observations of loop diuretic withdrawal after congestive heart failure.

BACKGROUND: Myxomatous mitral valve disease (MMVD) is a common cause of congestive heart failure (CHF) in small-breed dogs. Clinical observations suggest that discontinuation of loop diuretics may be ...