Regulatory T cells in cardiac allograft vasculopathy: from mechanistic insights to clinical tolerance.
Cardiac allograft vasculopathy (CAV) is the primary impairment that influences the long-term prognosis of transplanted hearts. CAV is characterized by diffuse intimal hyperplasia of the coronary arter...
Behavioral and health-factor domains of Life's Essential 8 in advanced cardiovascular-kidney-metabolic syndrome among Korean adults: a nationally representative cross-sectional analysis.
INTRODUCTION: Life's Essential 8 (LE8) summarizes cardiovascular health through four behavioral and four health-factor metrics, whereas cardiovascular-kidney-metabolic (CKM) syndrome staging character...
Impact of cavernous internal carotid artery tortuosity on technical and clinical outcomes in mechanical thrombectomy for acute ischemic stroke: a single-center retrospective study.
BACKGROUND AND PURPOSE: Cavernous internal carotid artery (ICA) tortuosity may hinder catheter navigation during mechanical thrombectomy (MT) for acute ischemic stroke (AIS). However, its impact on pr...
Astrocyte-blood-brain barrier crosstalk in cerebral small vessel disease: linking barrier dysfunction to neurovascular failure.
Cerebral small vessel disease (CSVD) is a heterogeneous group of disorders involving the cerebral microvasculature and is a major cause of stroke and vascular cognitive impairment. The role of blood-b...
Efficacy and safety of transarterial chemoembolization combined with donafenib and camrelizumab for hepatocellular carcinoma with portal vein tumor thrombus: a dual-center, retrospective propensity score-matched analysis.
AIM: To evaluate the efficacy and safety of transarterial chemoembolization combined with donafenib and camrelizumab (TACE+D+C) versus TACE plus donafenib (TACE+D) in the treatment of hepatocellular c...
High sensitivity for peripartum cardiomyopathy among large language models during differential diagnosis consideration.
BackgroundPeripartum cardiomyopathy (PPCM) is a rare, potentially life threatening condition with nonspecific heart failure symptoms, often leading to delayed diagnosis. Large language models (LLMs) m...
CASP1 as a key autophagy-related gene in atherosclerosis: Identification by bioinformatics analysis and experimental validation.
OBJECTIVE: This study identified potential autophagy-related genes (ARGs) in atherosclerosis using bioinformatics strategies, aiming to explore novel therapeutic targets for the clinical management of...
HALP Score as a Novel Marker Associated with Coronary Collateral Circulation in Patients with Chronic Total Occlusion.
BACKGROUND: Coronary collateral circulation (CCC) is a key determinant of myocardial viability and prognosis in patients with chronic total occlusion (CTO). The hemoglobin, albumin, lymphocyte, and pl...
Global research trends and hotspots evolution in type 2 diabetes mellitus complicated with coronary heart disease: a bibliometric analysis from 2016 to 2026.
BACKGROUND: The comorbidity burden of type 2 diabetes mellitus complicated with coronary heart disease is steadily increasing. However, there is a lack of systematic mapping of the research landscape,...
Factors Associated With Time in Therapeutic Range Among Thai Patients with Non-valvular Atrial Fibrillation Taking Warfarin: Development of AHfHDP Score.
BackgroundIn Thai patients with non-valvular atrial fibrillation (NVAF), anticoagulation quality with warfarin remains suboptimal. Existing prediction tools for poor international normalized ratio (IN...
Interaction between genistein and the endothelial activation and stress index in relation to estimated 10-year atherosclerotic cardiovascular disease risk classification.
BACKGROUND: The Endothelial Activation and Stress Index (EASIX) has been proposed as a marker of endothelial stress and may be associated with atherosclerotic cardiovascular disease (ASCVD) risk. Whet...
Targeted metabolomics of postmortem human cardiac tissue using the Biocrates MxP Quant 500 kit.
AIM: This proof-of-concept study aimed to evaluate the feasibility and analytical performance of the Biocrates MxP® Quant 500 kit, originally developed for biofluids, to postmortem human cardiac tissu...
The aberrant right subclavian artery and non-recurrent laryngeal nerve: a cadaveric study.
BACKGROUND: The aberrant right subclavian artery (ARSA), or arteria lusoria, is an aortic arch variant in which the right subclavian artery arises distal to the left subclavian artery and typically fo...
Effects of Acupuncture on Arterial Hypertension and Endothelial Dysfunction: The AHEaD Trial.
BACKGROUND: Sympathetic overactivity, oxidative stress, and impaired nitric oxide (NO)-mediated vasodilation are key mechanisms involved in the pathogenesis of hypertension. Acupuncture may decrease b...
[Thoracobifemoral bypass surgery with replacement of visceral arteries in a patient with nonspecific aortoarteritis].
The authors present a rare case of severe symptomatic involvement of multiple vessels in a young female patient with nonspecific aortoarteritis (Takayasu's disease). She underwent thoracobifemoral byp...
Thermomechanics analysis of cryopreservation by vitrification of the popliteal artery.
This study aims at exploring packaging configurations and thermal protocols to reduce thermomechanical stress during cryopreservation by vitrification of the popliteal artery and thereby reducing the ...
Combining MRI dual-sequence radiomics and clinical parameters predicts post-hypertriglyceridemic acute pancreatitis diabetes mellitus.
BACKGROUND: Post-acute pancreatitis diabetes mellitus (PPDM-A) represents the most prevalent subtype of diabetes secondary to exocrine pancreatic dysfunction. Patients with acute pancreatitis (AP) cau...
Neuro-immune-vascular interactions in rosacea and hypertension: a mechanistic review.
Rosacea is a chronic inflammatory skin disorder characterized by recurrent flare-ups and significant variability in therapeutic responses. Its pathophysiology is complex and involves multilevel proces...
Primary aldosteronism and obstructive sleep apnea in hypertension: interplay, target organ damage, and clinical management.
Primary aldosteronism (PA) and obstructive sleep apnea (OSA) are common but often unrecognized contributors to hypertension. When they coexist, aldosterone excess, fluid redistribution, intermittent h...
Age-Stratified Prognostic Comparison of Three Chronotropic Incompetence Definitions in Patients with Suspected Coronary Artery Disease Undergoing Exercise Stress SPECT-MPI.
BACKGROUND: Chronotropic incompetence (CI) is an exercise-derived marker of impaired heart rate response with prognostic relevance in myocardial perfusion imaging, but its interpretation may vary by d...