Gut Microbiota-Derived Butyrate Strengthens Blood-Brain Barrier Integrity and Attenuates Streptococcus suis SC19-Induced Meningitis: Involvement of the Gut-Brain Axis.

Streptococcus suis serotype 2 (SS2) is a major zoonotic pathogen that causes severe meningitis and high mortality in both humans and swine. Growing evidence shows that metabolites generated along the ...

Spatiotemporal Dynamics and Cellular States of Neuroinflammation in Amyotrophic Lateral Sclerosis: Implications for Stage‑Specific Therapeutics.

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with a complex and heterogeneous pathogenesis. Accumulating preclinical and clinical evidence indicates that neuroinflammation is an ...

Precision Drug Delivery Strategies for Treatment-Resistant Depression: Opportunities and Challenges of FUS-BBBO and Spatial Molecular Profiling.

In this review, treatment-resistant depression (TRD),a clinically defined subtype of major depressive disorder, is characterized by substantial disease burden and heterogeneous pathophysiology, with m...

Prodrug Strategies in Atherosclerosis: Targeted Delivery and Therapeutic Advances.

Non-pharmacological interventions for blood pressure management in hypertensive patients: selection of exercise regimens-a systematic review and network meta-analysis.

OBJECTIVE: To compare and rank the effects of exercise modalities on blood pressure in adults with hypertension. METHODS: We conducted a PRISMA-NMA-compliant systematic review and network meta-analysi...

Association between stress hyperglycemia ratio and acute total occlusion in patients with non-ST-segment elevation myocardial infarction.

BACKGROUND: Acute total occlusion (ATO) of the culprit artery identifies a high-risk subgroup of patients with non-ST-segment elevation myocardial infarction (NSTEMI), but its early recognition remain...

A clinical prediction model integrating cardiovascular-kidney-metabolic biomarkers for the composite outcome of quality-of-life deterioration and rehospitalization in elderly HFpEF patients.

BACKGROUND: Cardiovascular-kidney-metabolic (CKM) syndrome stage 4a encompasses elderly heart failure with preserved ejection fraction (HFpEF) patients with metabolic risk factors or chronic kidney di...

Perivascular diffusion and white matter free water improve identification of cognitive impairment in cerebral small vessel disease.

INRODUCTION: Cerebral small vessel disease contributes substantially to cognitive decline in older adults, but conventional structural magnetic resonance imaging markers mainly reflect accumulated les...

Anatomical study of the medial sural artery perforator flap and its application in the reconstruction of infected defects.

The medial sural artery perforator (MSAP) flap is widely used clinically for infected soft tissue defect repair and reconstruction due to its numerous advantages. However, the safe boundary of it was ...

Systemic inflammation and endothelial dysfunction influence the risk and severity of hemorrhagic transformation after endovascular treatment for acute ischemic stroke.

BACKGROUND: Hemorrhagic transformation (HT) is a frequent and serious complication, occurring in up to 40% of cases after endovascular treatment (EVT) for acute ischemic stroke (AIS). Inflammation has...

Triglyceride-glucose index is associated with the severity of coronary artery disease.

Cardiovascular disease(CVD) remains a leading cause of mortality worldwide. Among CVDs, coronary heart disease (CHD) is the most prevalent and represents the primary contributor to chronic disease-rel...

Characteristics of Adults Participating in Community Blood Pressure Screening Events: An Exploratory Cross-Sectional Analysis.

BACKGROUND: Community health events can be useful venues in hypertension control interventions, especially in low-income populations. This project performed blood pressure (BP) screenings at community...

Characteristics of Adults Participating in Community Blood Pressure Screening Events: An Exploratory Cross-Sectional Analysis.

BACKGROUND: Community health events can be useful venues in hypertension control interventions, especially in low-income populations. This project performed blood pressure (BP) screenings at community...

Sex-based differences in clinical outcomes among patients with obesity and heart failure with preserved ejection fraction treated with tirzepatide.

BackgroundSex-related differences are well recognized in heart failure with preserved ejection fraction (HFpEF), but real-world data describing clinical outcomes by sex among patients with obesity and...

Associations Between Socioeconomic Disadvantage and Rurality With New Diagnoses of Atrial Fibrillation.

BACKGROUND: Atrial fibrillation (AF) is common and causes significant morbidity and mortality. However, U.S. data on socioeconomic status, rurality, and new diagnoses of AF (NDAF) have been limited an...

Impact of Blood Donation Frequency on the Prevalence of Cardiovascular Risk Factors Among Donors.

BACKGROUND: Regular blood donation has been associated with lower cardiovascular risk in some studies, possibly through mechanisms involving reduced iron stores and oxidative stress. OBJECTIVE: The st...

Attenuated Impact of Gestational Diabetes Mellitus (GDM) With Hypertensive Disorders of Pregnancy (HDP) on Adverse Pregnancy Outcomes in Twin Versus Singleton Gestations: A Single-Center Real-World Study.

OBJECTIVE: Gestational diabetes mellitus (GDM) and hypertensive disorders of pregnancy (HDP) are two of the most prevalent pregnancy complications affecting both singleton and twin pregnancies worldwi...

The complete anatomy of the superior cerebellar artery: a systematic review and meta-analysis with clinical implications.

BACKGROUND: The aim of this systematic review and meta-analysis was to provide a comprehensive quantitative evaluation of the origin, morphology, branching patterns, topography, and cranial nerve rela...

Computed tomography angiographic examination of coronary sinus morphometry and spatial orientation: a guide for cardiac resynchronization therapy procedures.

BACKGROUND: This study aimed to characterize the morphometric features and three-dimensional spatial orientation of the coronary sinus ostium (CSO) within the right atrium using computed tomography an...

Incomplete celiac trunk with replaced hepatic arteries: a rare cadaveric case and embryologic interpretation.

BACKGROUND: The celiac trunk and superior mesenteric artery (SMA) are developmentally interconnected, and variations in one system often directly influence the other. Although classifications have bee...