Diagnostic Yield of Exome Sequencing in Patients With Congenital Heart Disease From Southern Africa.
Congenital heart disease (CHD) is a leading cause of pediatric morbidity and mortality worldwide. The genetics of CHD in African populations is not well understood, although it has been shown in other...
Cardiology Provider Knowledge and Attitudes Toward Cardiac Gene Therapy: A Multi-Institutional National Survey.
2026 HRS/AHA/APHRS/EHRA/IDSA/LAHRS/PACES/STS expert consensus statement update on cardiovascular implantable electronic device lead management and extraction.
The "2026 HRS Expert Consensus Statement Update on Cardiovascular Implantable Electronic Device Lead Management and Extraction" provides updated recommendations to guide clinicians in the management o...
Advanced maternal age at first delivery as a risk factor for long-term cardiovascular disease.
An increased numbers of women initiate motherhood at an advanced age. Advanced maternal age (AMA) at first delivery poses unique clinical challenges; however, limited literature exists regarding poten...
Beyond the review: additional non-oncologic drugs with clinically significant cardiovascular effects.
Clinical and Economic Outcomes Following First-Time Myocardial Infarction: A Nationwide Cohort Study from the SWEDEHEART Registry.
This study aimed to estimate consequences of myocardial infarction (MI) on long-term outcomes and resource needs by comparing outcomes, healthcare resource use, and associated costs between first-time...
Multimodality imaging in the detection and management of coronary and peripheral arterial disease in patients with cancer receiving cardiotoxic antineoplastic treatments. A clinical consensus statement of the ESC Council of Cardio-Oncology and the European Association of Cardiovascular Imaging (EACVI) of the ESC.
Early detection of cancer and advances in treatment have significantly improved the survival rate of patients with cancer. Both cancer and its treatment can accelerate the onset of cardiovascular dise...
Non-invasive pressure-volume loops by cardiovascular magnetic resonance and outcome in ST-elevation myocardial infarction.
We aimed to investigate if non-invasive pressure-volume (PV) loop variables by cardiovascular magnetic resonance (CMR) are associated with all-cause mortality or heart failure compared to mean arteria...
Gaps in cardiovascular risk identification and preventive therapy before first myocardial infarction.
Long-Term Efficacy and Safety of GLP-1R Agonist and SGLT2 Inhibitor Therapy in the General Population: A Mendelian Randomization Study.
SGLT2 (sodium-glucose cotransporter-2) inhibitors and GLP-1R (glucagon-like peptide-1 receptor) agonists reduce the risk of major adverse cardiovascular and kidney events in individuals with various c...
Inhibition of the PD-1 immune checkpoint and the development of heart failure in the presence of prior cardiac ischemia.
Immune checkpoint inhibitors (ICI) have revolutionized cancer treatment. However, their use often leads to cardiovascular adverse effects, including cardiac dysfunction. Here, we hypothesized that a p...
The immunometabolic role of pyruvate dehydrogenase kinase/pyruvate dehydrogenase axis in cardiovascular disease and beyond.
The pyruvate dehydrogenase kinase (PDK)/pyruvate dehydrogenase (PDH) axis plays a pivotal role in regulating cellular energy metabolism, controlling the flux between the tricarboxylic acid cycle and o...
Shockwave Intravascular Lithotripsy in Transvenous Lead Extraction of Leads with Dwell Time ≥10 Years.
Lead dwell time (DT) is associated with increased complexity of cardiac implantable electronic device (CIED) extraction. Optimal strategies for risk mitigation are not well studied. Evaluate the role ...
Determinants of Recurrence After Epicardial Ventricular Tachycardia Ablation in Structural Heart Disease.
Epicardial catheter ablation is an established treatment for ventricular tachycardia (VT) in patients with structural heart disease (SHD); however, VT recurrence remains frequent, particularly in adva...
Initial Experience Using a Variable Loop Circular Pulsed Field Ablation Catheter to Treat Atrial Arrhythmias in Complex Congenital Heart Disease Patients.
Physical Activity in Pediatric Cardiomyopathies: Moving for Health: A Scientific Statement From the American Heart Association.
Physical activity (PA) is essential for the cardiovascular, emotional, and social health of all children and adolescents. However, for pediatric patients with cardiomyopathy, decades of risk-averse cl...
Cell-specific vulnerabilities and adaptations in atrial aging.
Aging is the major risk factor for cardiovascular disease, the leading cause of death worldwide. Research on age-related cardiac pathologies has predominantly centered on the left ventricle; however, ...
Diagnostic validation and prognostic implications of serial 0/1/3h stratification in patients with suspected myocardial infarction using high-sensitivity troponin T.
The European Society of Cardiology (ESC) recommends 0/1h-algorithms for triage of patients with suspected myocardial infarction (MI). Recently, cut-offs allowing 3h triage using high-sensitivity cardi...
Pregnancy in women with autoimmune diseases and cardiovascular risk in the offspring: a Swedish population-based cohort study.
Maternal autoimmune diseases (AIDs) have been linked to adverse birth outcomes that may potentially increase cardiovascular disease (CVD) risk in offspring. However, whether maternal AIDs is associate...
Balancing Clinical and Ethical Considerations Related to Placebo Use in Trials of Incretin-Based Therapies in Heart Failure.
Recent trials have shown that glucagon-like peptide 1 receptor agonists (GLP-1 RAs) and dual gastric inhibitory polypeptide/GLP-1 RAs improve symptoms and functional capacity in patients with heart fa...