Rethinking Mitochondria: The Extracellular Dimension.
Mitochondria are essential organelles that transform the energy contained in metabolic substrates into ATP while supporting numerous cellular processes. Traditionally regarded as strictly intracellula...
Serum Neurofilament Light Chain and Cardiovascular Outcomes in Patients With Atrial Fibrillation.
Serum neurofilament light chain (sNfL) is a blood-based biomarker initially investigated for neuronal injury and is elevated in patients with atrial fibrillation (AF). Whether sNfL is associated with ...
Long-Term Durability of Acoramidis Efficacy in Transthyretin Amyloid Cardiomyopathy: Open-Label Extension of the ATTRibute-CM Randomized Clinical Trial.
Transthyretin amyloid cardiomyopathy (ATTR-CM) is a progressive disorder caused by destabilization of serum transthyretin (sTTR). Acoramidis, an approved therapy that achieves near-complete (≥90%) sTT...
Statin Eligibility According to Atherosclerotic Cardiovascular Disease Risk in the US-Reply.
Statin Eligibility According to Atherosclerotic Cardiovascular Disease Risk in the US.
RBM20 Truncating Variants and Human Cardiomyopathy.
Genetic diagnosis has become increasingly important to guide clinical decision-making for patients with dilated cardiomyopathy (DCM). Pathogenic or likely pathogenic (P/LP) missense variants in the ge...
Partial cor triatriatum sinistrum case series: is percutaneous balloon dilatation a promising alternative to surgery?
Partial cor triatriatum sinistrum is a rare congenital heart disease and is usually considered for surgery in symptomatic patients. We describe three cases of partial cor triatriatum sinistrum, two ca...
Case Report: Angiographic Remodeling of a Chronic Total Occlusion Four Years After Extraplaque Wiring: Implications for Procedural Reattempt.
An investment procedure during chronic total occlusion (CTO) percutaneous coronary intervention (PCI) involves intentional alteration of the proximal cap with the aim of facilitating subsequent CTO PC...
Severe polyarterial involvement in a 16-year-old with homozygous familial hypercholesterolaemia: a case report.
Homozygous familial hypercholesterolaemia (HoFH) is a rare genetic disorder characterized by an elevated plasma concentration of low-density lipoprotein cholesterol (LDL-C) starting at birth and a sig...
Thyroid dysfunction and cardiovascular disease.
Thyroid hormones play an important role in regulating the cardiovascular system. Thyroid dysfunction, which encompasses hypothyroidism and hyperthyroidism, is relatively common and has been linked to ...
Eicosapentaenoic acid ethyl ester, cardiac metabolomic and lipidomic signatures, and cardioprotection in myocardial infarction.
The cardiovascular benefits of eicosapentaenoic acid ethyl ester (EPA-E) in MACE reduction might extend beyond its triglyceride (TG)-lowering effects. However, the mechanism behind remains unknown. Th...
Electrophysiology in Adults With Congenital Heart Disease as an Area of Focused Competency.
Visual Acuity and Cardiovascular Mortality in 2.52 Million Older Adults in China.
Visual acuity (VA) impairment and cardiovascular disease (CVD) are major global health burdens. Although impaired VA is linked to elevated all-cause mortality risk, its association with CVD mortality,...
Low-Level Airborne Particulate Matter and Risk of Hypertension Hospitalization in Older U.S. Adults.
Although long-term exposure to fine particulate matter (particles ≤ 2.5 μm in diameter [PM2.5]) has been linked to adverse cardiovascular outcomes, evidence remains limited regarding the effects of PM...
Comparative Cardiovascular Effectiveness of Glucagon-Like Peptide 1 Receptor Agonists and Sodium-Glucose Cotransporter 2 Inhibitors in Diabetes Mellitus.
Glucagon-like peptide 1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter 2 inhibitors (SGLT2Is) have established cardiovascular benefits for patients with type 2 diabetes mellitus (T2DM),...
Interchangeability of the KCCQ-12 and KCCQ-23 Across >18,000 Participants Enrolled in 4 Large-Scale Trials of Heart Failure.
The 23-item Kansas City Cardiomyopathy Questionnaire (KCCQ-23) is formally qualified by the Food and Drug Administration as a valid patient-reported outcome measure for use in heart failure (HF) clini...
Multi-Organ Physiologic Deficits During Exercise Identify Clinical and Molecular Predisposition to Heart Failure with Preserved Ejection Fraction.
Exercise unmasks limitations in multi-organ system reserve capacity characteristic of heart failure with preserved ejection fraction (HFpEF). However, the metabolic and genetic underpinnings of exerci...
Phone-Based Intervention Under Nurse Guidance for Control of Hypertension After Stroke: A Randomized Multicenter Phase 3 Trial in Ghana.
Addressing the rising burden of stroke in low-income countries will require pragmatic and scalable interventions targeting major risk factors. Under routine care settings, <10% of adults living with h...
Rapid Genome Sequencing Shows Diagnostic Utility in Infants With Congenital Heart Defects.
Congenital heart disease (CHD) is the most common birth defect and a leading cause of infant mortality. CHD often has a genetic cause, and recent studies demonstrate the utility of genetic testing. In...
Response by Murchland et al to Letter Regarding Article, "Experiences of Stalking and Obtaining a Restraining Order Are Associated With Onset of Cardiovascular Events in Women: A Prospective Analysis in the Nurses' Health Study II".