Response to PCSK9 Inhibition Based on LDL Receptor Function in Familial Hypercholesterolemia: A Nonrandomized Clinical Trial.
In individuals with heterozygous familial hypercholesterolemia (HeFH), it is uncertain whether and to what extent the reduction in low-density lipoprotein cholesterol (LDL-C) with proprotein convertas...
Multi-modality non-invasive cardiovascular screening and sex-specific outcomes: the Viborg Screening Program.
Cardiovascular screening has been shown to reduce mortality in trials involving men. This study evaluated the effect of cardiovascular screening in both sexes, with all-cause mortality as the primary ...
Carotid Plaque Inflammation and Calcification on Somatostatin Receptor PET/CT Imaging Predict Stroke and Major Adverse Cardiovascular Events.
Carotid atherosclerosis is a risk factor for stroke and major adverse cardiovascular events (MACE) and is characterized by inflammation and calcification at different stages. Simultaneous assessment o...
A Changing Climate Requires Changing Tools: Environmental Exposures and Cardiovascular Health through a CMR Imaging Lens.
Initiation of Eplerenone vs Spironolactone and All-cause Mortality in HFrEF: Linked Database Study.
Mineralocorticoid receptor antagonists (MRAs) are recommended as part of guideline-directed medical therapy for heart failure with reduced ejection fraction (HFrEF). The comparative effectiveness of s...
From valve prosthesis to coronary artery: a fatal thrombus: a case report.
Coronary embolism is an uncommon cause of acute myocardial infarction, often related to atrial fibrillation or valvular heart disease. In such cases, concomitant valvular thrombosis requires additiona...
Aligning Coronary Stent Trial Enrollment With the U.S. Intended-Use Population: Implications of Site Selection.
Class III cardiovascular device premarket approval (PMA) studies often fail to fully represent the intended-use population (IUP) owing to low enrollment of racial and ethnic minority subjects and wome...
A Step Toward Diversity and Inclusion in Cardiovascular Research Trials.
Contemporary Trends in Percutaneous Coronary Intervention at Facilities Without On-Site Cardiac Surgery: Insights From the National Cardiovascular Data Registry.
Development and Validation of a Clinical Polygenic Risk Report in U.S.-Based Health Systems for 8 Cardiovascular Conditions.
Polygenic risk scores (PRS) stratify inherited cardiovascular risk, but their path to clinical implementation remains unclear. We aimed to develop and validate integrated PRS for 8 cardiovascular cond...
Clinical Documentation of an Individualized Emergency Action Plan for Young Athletes With Cardiovascular Conditions at Risk for Sudden Cardiac Arrest.
Mechanisms and therapeutic potential of colchicine in atherosclerotic cardiovascular disease.
Over the past decade, colchicine has re-emerged as a promising therapeutic candidate for atherosclerotic cardiovascular disease. Here we review evidence from large randomized controlled trials togethe...
Oxygenation-Sensitive Cardiovascular Magnetic Resonance Imaging to Identify Coronary Microvascular and Vasomotor Dysfunction in Angina and No Obstructive Coronary Artery Disease.
Endothelial-dependent coronary microvascular and vasomotor dysfunction (CMVD), which requires invasive coronary function test (ICFT) with intracoronary acetylcholine for diagnosis, is the predominant ...
Highlights from the first interdisciplinary summit of the European Association of Cardiovascular Imaging and the European Society for Cardiovascular Radiology.
Advancing Women's Health Through Public Policy.
Micro(nano)plastics in the Development of Myocardial Fibrosis: From Clinical Detection to Molecular Mechanism.
Micro(nano)plastics (MNPs) are pervasive environmental contaminants, yet their presence in human cardiac tissue and their potential contribution to myocardial fibrosis remain unclear. We investigated ...
Genetic determinants of childhood blood pressure and heart rate in relation to adult health outcomes: the consortium of childhood blood pressure.
To elucidate the genetic architecture of blood pressure (BP) and heart rate (HR) during early life and assess their potential relevance to adult health outcomes. The largest genome-wide association st...
Prognostic impact of cardiovascular magnetic resonance-derived left atrioventricular coupling Index in patients with severe aortic stenosis undergoing transcatheter aortic valve replacement.
Transcatheter aortic valve replacement (TAVR) is an established therapy improving outcome in patients with severe aortic stenosis (AS). Cardiovascular magnetic resonance (CMR)-derived left atrioventri...
Posterior mitral leaflet hypoplasia in adults: diagnostic value of three-dimensional transoesophageal echocardiography: a case series.
Posterior mitral leaflet (PML) hypoplasia is a rare and frequently under-recognized condition in adults, as transthoracic echocardiography (TTE) findings may be subtle. Transoesophageal echocardiograp...
Implementation of novel antithrombotic treatment strategies and outcome improvements in patients with myocardial infarction and atrial fibrillation over 20 years: a nationwide cohort study.
Patients with acute myocardial infarction (MI) and atrial fibrillation (AF) present challenges in antithrombotic treatment. Effects of newer treatment strategies on outcomes remain uncertain. We asses...