Oral PCSK9 Inhibitor Enlicitide Versus Oral Nonstatin Therapies: A Phase 3 Randomized Clinical Trial.

Many adults fail to achieve guideline-directed low-density lipoprotein cholesterol (LDL-C) goals on statin monotherapy, requiring additional nonstatin lipid-lowering medication. Enlicitide, an oral pr...

Body Mass Index, Clinical Outcomes, and Mortality in Heart Failure: A Mendelian Randomization Study.

Excess adiposity, most commonly indexed through body mass index (BMI), is strongly associated with the development of heart failure (HF). Weight loss therapies improve outcomes in patients with obesit...

Midlife Cardiorespiratory Fitness and Healthy Aging: An Observational Cohort Study.

Higher cardiorespiratory fitness (CRF) is associated with a lower risk for chronic disease and death, but its relation to healthy aging more broadly remains understudied. The aim of this study was to ...

Focal and Diffuse Coronary Artery Disease Patterns and Placebo-Controlled Angina Relief With Percuatenous Coronary Intervention: ORBITA-2.

Unblinded studies have demonstrated superior procedural and clinical outcomes of percutaneous coronary intervention (PCI) in focal compared with diffuse coronary artery disease. However, data from the...

How to Image Myocarditis.

Myocarditis is an inflammatory disease involving the heart muscle and potentially the pericardium. While there are many potential causative agents, commonly grouped into infectious (viral, bacterial, ...

Rare KDR Variants Define a Distinct Genetic Contribution to Congenital Heart Disease.

Monoclonal antibodies targeting IL-5/5R or IL-4/13 pathways in eosinophilic myocarditis: a single-center experience and systematic literature review.

Eosinophilic myocarditis (EM) is a rare inflammatory heart disease often associated with eosinophilic granulomatosis with polyangiitis or hypereosinophilic syndrome. While anti-IL-5/5R and anti-IL-4/1...

Splenic Tissue Alterations in ST-Elevation Myocardial Infarction: Determinants and Prognostic Implications.

While previous studies suggest a cardio-splenic axis involving splenic activation and systemic inflammation, presence and clinical significance of splenic tissue alterations on cardiac magnetic resona...

From Air Pollution Association to Actionable Prevention: Silent Myocardial Fibrosis as the Next Frontier in Cardiovascular Imaging.

Letter by Luo et al Regarding Article, "Screening-Detected Atrial Fibrillation and Cardiovascular Outcomes in Working-Age Adults".

Response by Mori et al to Letter Regarding Article, "Screening-Detected Atrial Fibrillation and Cardiovascular Outcomes in Working-Age Adults".

Outcomes of Cardiac Resynchronization Therapy in Adults with Congenital Heart Disease and Heart Failure with Reduced Ejection Fraction.

There are limited data about the role of cardiac resynchronization therapy (CRT) in adults with congenital heart disease (CHD) and heart failure with reduced ejection fraction (HFrEF). (i) Assess the ...

Integrating ECG and echocardiography to identify early-stage transthyretin amyloid cardiomyopathy.

Current diagnostic criteria for transthyretin amyloid (ATTR) cardiomyopathy (ATTR-CM) emphasize increased left ventricular (LV) wall thickness, potentially delaying recognition of early myocardial inv...

Valve-in-valve transcatheter pulmonary valve replacement in carcinoid heart disease: a case report.

Carcinoid heart disease (CHD) commonly affects right-sided heart valves, often leading to progressive right heart failure (RHF) and structural valve deterioration. A 30-year-old male with CHD and prio...

Transcatheter closure of a ruptured sinus of Valsalva aneurysm-a minimally invasive approach to a rare cardiac emergency: a case report.

Sinus of Valsalva aneurysm (SVA) is a rare but clinically significant cardiac anomaly, arising congenitally or through acquired causes. Typically, asymptomatic until rupture, this condition can precip...

Inflammation-related acute coronary thrombosis following vaccination: a case report.

Acute chest pain and troponin changes in middle-aged individuals can pose a diagnostic challenge, as age-related vascular changes may complicate common inflammatory and infectious conditions, affectin...

JNK2 Is a Stress Integrator Driving Atrial Fibrillation Pathogenesis in Aging via Gut-Heart Crosstalk.

Atrial fibrillation (AF) is the most common arrhythmia and is associated with high morbidity and mortality, particularly in the aging population. Current treatment and prevention strategies remain sub...

Randomized, Placebo-Controlled Trial of Chronic Total Occlusion Percutaneous Coronary Intervention in Stable Angina: The ORBITA-CTO Trial.

Percutaneous coronary intervention for coronary chronic total occlusion (CTO PCI) is offered for symptom and quality of life improvement, despite the absence of blinded randomized evidence. The aim of...

Endothelial decorin in cardiac ageing: mechanistic ambiguities and therapeutic challenges.

This letter provides a critical analysis of the recent study by Luxán et al. (Cardiovasc Res. 2025) on the role of non-glycanated decorin in cardiac ageing. While acknowledging the importance of their...

Single nucleus RNA sequencing and functional in vivo studies reveal TCF21 as a protective regulator in cardiac fibrosis.

Cardiac fibrosis remains a significant and currently untreatable contributor to mortality in chronic heart disease. This study aimed to comprehensively map cell-specific pathological changes in fibrot...