Small Animal Models for Translational Research in Atrial Fibrillation.

Atrial fibrillation (AF) is a common arrhythmia with significant morbidity and mortality, making it essential to conduct in-depth research on its mechanisms and treatments. Animal models are important...

Impact of Microaxial Flow Pump on Coronary Flow Dynamics in Normal Hearts: An Experimental Evaluation.

The effects of microaxial flow pump (mAFP) support on coronary flow (CF) are well characterized in failing hearts, but its impact on CF in normal hearts under different levels of left ventricular (LV)...

Global research trends and clinical theme evolution in robot-assisted nephrectomy with venous tumor thrombectomy for renal cell carcinoma: a bibliometric and visualization analysis.

Robot-assisted nephrectomy with renal vein or inferior vena cava (IVC) tumor thrombectomy is a technically demanding procedure used in selected patients with renal cell carcinoma (RCC) and venous tumo...

Robotic pancreaticoduodenectomy with venous resection and reconstruction: a systematic review of perioperative, vascular, oncological and survival outcomes.

Robotic pancreaticoduodenectomy with venous resection and reconstruction (RPD-VR) is one of the most technically challenging procedures in hepatopancreaticobiliary surgery. While acceptance of robotic...

Gastrodin mitigates cisplatin-induced cardiotoxicity in Swiss albino mice by restoring redox homeostasis and modulating the p62-Keap1-Nrf2 Axis.

BACKGROUND: Cisplatin (CP) chemotherapy can elicit clinically meaningful cardiac injury, and the additional use of effective cardioprotective agents is a pressing need. This study investigated the pro...

Multifactorial acute kidney injury with findings suggestive of arcuate venous thrombosis: a case report.

Renal arcuate vein thrombosis (RAVT) is a rare and often underrecognized cause of acute kidney injury (AKI) that typically requires renal biopsy for diagnosis. We report a 29-year-old man who develope...

Endotype-guided medical therapy and symptom response in ANOCA.

BACKGROUND: Invasive coronary functional testing enables the classification of angina with non-obstructive coronary arteries (ANOCA) into distinct endotypes. However, real-world data linking endotype ...

Predictive value of the serum sodium to log(D-dimer) ratio for the risk of all-cause death in patients with chronic heart failure with different ejection fractions.

BACKGROUND: The ratio of serum sodium to log(D-dimer) (log-SDR) in different types of chronic heart failure (CHF) is not well established. METHODS: A total of 1,221 hospitalized CHF patients from the ...

Quantitative assessment of systolic and diastolic left ventricular energy loss using vector flow mapping in healthy participants: a retrospective observational study.

BACKGROUND: Energy loss (EL) derived from vector flow mapping (VFM) is an indicator of intraventricular flow efficiency in the left ventricle. However, standardized reference values in adults have not...

Autophagy-Lysosomal Dysfunction as a Converging Mechanism of Cardiomyopathy in Lysosomal Storage Disorders: From Pathobiology to Targeted Therapy.

Cardiac disease is a leading cause of morbidity and early death across several lysosomal storage disorders (LSDs); however, the cardiomyopathies of Fabry, Pompe, and Danon disease are still largely tr...

Association of SCAP Gene Polymorphisms with Ambulatory Blood Pressure Parameters in College Students.

Background/Objectives: Abnormal blood pressure (BP) in youth is strongly linked to genetic predisposition, particularly involving lipid metabolism genes. However, little is known about whether such po...

Multi-organ transcriptome profiling in an isogenic cachexia-inducing xenograft model to dissect host responses across heart, liver, kidney, and muscle.

Cancer cachexia is a debilitating systemic syndrome that affects a substantial proportion of patients with advanced malignancy and is associated with impaired treatment tolerance, reduced quality of l...

Extra-Anatomical Aortic Bypass for Infected Aortic Arch Stent Graft: A Case Series.

BACKGROUND Aorto-aortic extra-anatomical bypass is a specialized surgical intervention primarily used to manage complex vascular complications, including stent graft infections after endovascular aort...

A non-bactericidal antimicrobial peptide provides protective effect against bacterial sepsis via regulation of antimicrobial immunity and vascular endothelial functions.

The anti-infective properties of bactericidal antimicrobial peptides (AMPs) have been extensively studied, yet the functions and mechanisms of non-bactericidal AMPs in sepsis remain poorly understood....

Baicalein Attenuates High Glucose and Sodium Palmitate-Induced Ferroptosis in Cardiomyocytes via the Nrf2/SLC7A11/GPX4 Signaling Pathway.

Diabetes mellitus (DM) is increasing rapidly worldwide, and diabetic cardiomyopathy (DCM) has become a leading cause of death in diabetic patients. Therefore, effective strategies for the prevention a...

LAMB2 p.E991K Mutation-Mediated Atherosclerosis in Rabbit.

Background: Atherosclerosis is a major pathological basis of cardiovascular disease and is influenced by both genetic and environmental factors. Although genome-wide association studies have identifie...

Prognostic Impact of Baseline Potassium Abnormalities in Patients with Heart Failure with Reduced Ejection Fraction: A Real-World Cohort Study.

INTRODUCTION: Abnormal serum potassium levels are a common issue in patients with heart failure with reduced ejection fraction (HFrEF), limiting the use of prognostically beneficial therapies. The pri...

Asymptomatic Atrial Fibrillation in Contemporary Clinical Practice: Insights from the REGUEIFA Registry.

Background: Asymptomatic atrial fibrillation (AF) represents a substantial proportion of diagnosed AF cases; however, its prognostic implications remain controversial. This study aimed to compare clin...

APEX1 attenuates myocardial ischemia-reperfusion injury by inhibiting ferroptosis via the Nrf2/GPX4 signaling pathway.

BACKGROUND: Myocardial ischemia reperfusion injury (MIRI) is a primary cause of poor prognosis in patients with myocardial infarction, with ferroptosis being a significant form of cell death in this p...

A 79-Year-Old Woman With Stage IIIB Lung Squamous Cell Carcinoma Presenting With Late-Onset Durvalumab‑Associated Myocarditis Requiring Differentiation From Pericardial Invasion.

BACKGROUND Durvalumab is a humanized monoclonal antibody and immune checkpoint inhibitor used for the treatment of advanced non-small cell lung cancer. Myocarditis, particularly in late-onset cases, i...