Effects of methylphenidate on the human vascular endothelium.

Methylphenidate (MPH) is a widely used psychostimulant for treating attention-deficit/hyperactivity disorder (ADHD). Emerging epidemiological findings suggest that MPH treatment increases the risk of ...

Pre-existing vertebrojugular fistula unmasked following an uncomplicated internal jugular vein cannulation and its management.

A vertebrojugular fistula (VJF) is a vascular malformation characterised by abnormal communication between the vertebral artery (VA) and the internal jugular vein (IJV). It can occur following neck tr...

Unveiling perceptions: a small-scale qualitative case study related to patient experience of inpatient screening for familial hypercholesterolemia.

BACKGROUND: Familial hypercholesterolaemia (FH) is a hereditary, genetic disorder disrupting the metabolism of low-density cholesterol from birth. Untreated, 50% of men develop atherosclerotic cardiov...

Focused ultrasound blood-brain barrier opening reveals a paradoxical remote metabolic response in the primate brain.

Low-intensity focused ultrasound (LIFU) is a promising technique for opening the blood-brain barrier (BBB) for drug delivery, but its physiological consequences in remote brain regions remain a major ...

The Exercise-CTSS-AD Axis: a novel framework for understanding exercise-induced neuroprotection in Alzheimer's disease.

Disease-modifying therapies for Alzheimer's disease (AD) targeting amyloid-β and tau have consistently failed, highlighting the urgent need for innovative therapeutic strategies. Cathepsin S (CTSS), a...

Cardiovascular biomarkers in feline hypertrophic cardiomyopathy phenotype: evidence from the last decade.

The hypertrophic cardiomyopathy (HCM) phenotype is the most common feline cardiovascular condition, characterized by myocardial hypertrophy and variable hemodynamic changes, with diagnosis primarily b...

Mechanisms for Mineralocorticoid-Driven Age-Related Hypertension: Potential Therapeutic Role of Mineralocorticoid Receptor Antagonists and Aldosterone Synthase Inhibitors.

Hypertension prevalence rises dramatically with advancing age, is not well controlled with current therapy, and contributes substantially to cardiovascular, renal, and neurological disorders that are ...

GLP-1 Receptor Agonists: From Clinical Success to Mechanistic Insight.

GLP-1R (glucagon-like peptide-1 receptor) agonists are transforming therapeutic strategies in hypertension and cardiometabolic syndrome by shifting the focus from merely controlling individual risk fa...

Spatiotemporal orchestration of macrophage heterogeneity by cell adhesion molecules.

Monocyte-derived macrophages (mo-macs) are central regulators of innate immunity and are essential for maintaining physiological homeostasis and host defense. Their functional efficacy relies on preci...

Social Deprivation Index Is Associated with 90-Day Emergency Department Revisits, but Not Admission, for Acute Heart Failure.

BACKGROUND: Prevalence of heart failure is increasing, with an associated rise in emergency department (ED)-related care. Social determinants of health (SDoH) are associated with adverse health outcom...

Point-of-care Ultrasound for Detecting Methamphetamine-associated Heart Failure in the Emergency Department.

INTRODUCTION: Methamphetamine-associated heart failure with reduced ejection fraction is a serious consequence of methamphetamine use often underrecognized in the emergency department (ED). Point-of-c...

Comparison of Clinical Outcomes of Myval vs. Acurate Neo Valves in TAVR: A Single-Center Experience.

Background and Objectives: Transcatheter aortic valve replacement (TAVR) has become an established treatment for severe symptomatic aortic stenosis, and continuous technological advances have led to t...

Personalised approach to hypertension treatment: protocol for the HYPERMARKER randomised controlled trial.

INTRODUCTION: Blood pressure treatment response is variable in individual patients, and the choice of medical therapy is often dependent on clinician experience. Treatment choices could be personalise...

Differentiating HFmr/rEF from HFpEF using standard 12-lead ECG measurements: an interpretable machine learning study.

BACKGROUND: Differentiating heart failure (HF) with mildly reduced/reduced ejection fraction (HFmr/rEF) from HF with preserved ejection fraction (HFpEF) guides therapy but echocardiography may be dela...

Thyrotoxic periodic paralysis presenting with transient ventricular arrhythmia: a rare variant presentation of Graves' disease.

Thyrotoxic periodic paralysis (TPP) is a rare variant presentation associated with thyrotoxicosis. It is characterised by acute hypokalaemic paralysis due to intracellular potassium shift. We describe...

Automated Daily Phone Surveys in Older Adults: Feasibility Study in the Multi-Ethnic Study of Atherosclerosis.

BACKGROUND: An ecological momentary assessment (EMA) is a methodological framework designed to capture real-time data in a participant's natural environment, yet its feasibility in older adults, parti...

Implementation of a learning health system for the management of non-communicable diseases in Thailand: a realist evaluation protocol.

INTRODUCTION: Learning health systems (LHS) are an approach to translate patient data into actionable clinical insights, empower healthcare teams to drive quality improvement and reduce health inequal...

Machine Learning Analysis of Sex Differences in Cardiovascular-Kidney-Metabolic Risk Factors and Prognosis Among Patients With Moderate-to-Severe Coronary Artery Calcification: Prospective Cohort Study.

BACKGROUND: Patients with coronary artery calcification exhibit notable sex differences in clinical presentation, particularly concerning the role of cardiovascular-kidney-metabolic (CKM) risk factors...

Lifestyle and metabolic determinants of early- and late-onset colorectal cancer: insights from a tertiary medical center in Alabama.

PURPOSE: Early-onset colorectal cancer (EOCRC, < 50 years) is rising in the United States, whereas late-onset CRC (LOCRC, ≥ 50 years) is declining. Fewer studies have examined association between risk...

Genetic evidence links hypertension to accelerated brain aging.

Hypertension affects one-third of adults and is a major comorbidity of neurocognitive disorders. The causal relationship, shared genetic architecture, and upstream mechanisms linking hypertension to b...