Punch skin grafting for patients with no-option for revascularisation chronic limb-threatening ischaemia: A case series.

OBJECTIVE: No-option for revascularisation Chronic Limb-Threatening Ischaemia (CLTI) is often a terminal diagnosis for older patients, leading to survival and limb preservation rates that are of conce...

Patients' experiences living with claudication and healthcare professionals' perspectives of managing the condition: A qualitative study.

BACKGROUND: Peripheral artery disease (PAD) and claudication significantly affects mobility, leading to disability and reduced participation in daily activities. Regular physical activity improves wal...

The claudication symptoms questionnaire: Patient directed development and testing.

BACKGROUND: Symptomatic peripheral artery disease (PAD) is defined as calf pain when walking. However, over 70% of patients with PAD suffer from symptoms other than classic claudication pain (atypical...

Coexistence of peripheral artery disease and coronary artery disease: Prevalence and contributing factors.

BACKGROUND: Peripheral artery disease (PAD) is a common comorbidity among patients with coronary artery disease (CAD), and its presence is correlated with increased cardiovascular morbidity and mortal...

Serial Optical Coherence Tomography Assessment of Plaque Phenotype Stabilization after Paclitaxel-Coated Balloon Treatment in De Novo Coronary Lesions.

PURPOSE: There is limited evidence regarding serial plaque changes after paclitaxel-coated balloon (PCB) treatment in de novo coronary target lesions assessed using optical coherence tomography (OCT)....

The Glymphatic System in α-Synucleinopathies.

α-Synucleinopathies-including Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA)-are neurodegenerative disorders characterized by the pathological accumulatio...

Multimethod-guided discovery of novel α-pyrone dimers with cardiomyocyte-protective activity against cold ischemia injury from the coral-derived Talaromyces sp. TJ403-AL05.

Guided by molecular networking, HSQC-based DeepSAT, and SMART analyses, a chemical investigation of the coral-derived fungus Talaromyces sp. TJ403-AL05 led to the isolation and identification of talad...

A Review of the Therapeutic Potential of Stem Cell-Derived Nanocarriers to Treat Neurological Disorders.

Neurological disorders (NDs) are characterized by substantial loss of specific neurons, with Alzheimer's and Parkinson's diseases being the most frequent NDs and nearly 99% of all "foreign substances"...

DUSP1 Inhibits Mechanotransduction and MAPK Signalling to Alleviate Myocardial Cell Hypertrophy.

Hypertrophic Cardiomyopathy (HCM) is one of the significant causes of heart failure. This study aimed to identify and validate potential therapeutic targets for HCM through bioinformatics analysis and...

Introduction to Single-Cell Physiologically-Based Pharmacokinetic (scPBPK) Models.

The current investigation introduces single-cell physiologically based pharmacokinetic (scPBPK) models to gain insight into drug disposition at the cellular scale. The transition from standard PBPK (s...

Toward multilevel therapeutic targeting of medial arterial calcification in chronic kidney disease.

Despite decades of investigation, effective therapies for medial arterial calcification in chronic kidney disease remain lacking. Emerging therapeutic targets increasingly extend beyond systemic drive...

Challenging Anatomic and Pathologic Features for Transcatheter Aortic Valve Replacement Planning.

Segmentation and processing of CT datasets for transcatheter aortic valve replacement (TAVR) planning is now an essential part of the transcatheter heart valve team process. Output for TAVR planning i...

Downregulation of circ_0001112 Enhances Myocardial Infarction Through Regulation of miR-324-5p/CDK6 Axis.

Myocardial infarction (MI) usually results in severe heart failure (HF), and patients suffer from the repercussions of MI, elucidation of the pathological basis of MI is crucial to optimize the preven...

Epidemiological Transition of Renal Mortality in Chiapas (2000-2024): Autonomy of CKDu and the Rise of Hypertensive Nephropathy-A Time-Series Ecological Study.

AIM: Chronic kidney disease of non-traditional aetiology (CKDu) has been described in agricultural regions worldwide, yet its contribution to renal mortality in Mexico remains poorly characterised. Th...

Complex Posterior Chest Wall Reconstruction Using Bilateral Deep Inferior Epigastric Perforator Flaps After Failed Latissimus Dorsi Free Flap: A Case Report.

Radical resection of posterior chest wall sarcomas may result in extensive composite defects exposing lung parenchyma, prosthetic material, and spinal instrumentation, while simultaneously exhausting ...

Rethinking Transradial Compression Band Practice.

BACKGROUND: Transradial access (TRA) is a standard approach to cardiac catheterization. Following the procedure, air-filled compression bands are often used to achieve hemostasis at the access site. D...

Association of 10-year Cardiovascular Risk with Left Ventricular Hypertrophy in a Population of Nigerian Hypertensives.

BACKGROUND: The pooled cohort equation (PCE) for predicting the 10-year risk of atherosclerotic cardiovascular disease (ASCVD) has been utilised in Black populations to predict cardiovascular events. ...

What Happened When a Heart Failure Unit Asked for Help with Its Culture?

Communication and teamwork are essential for providing safe and effective health care, particularly in light of increasingly complex health care teams comprising multiple disciplines. In late 2021, th...

Dipeptidyl Peptidase-4 Inhibitors Associated Heart Failure Events in Adult Patients With Type-2 Diabetes Mellitus Treated With Dipeptidyl Peptidase-4 Inhibitors: A Systematic Review and Meta-Analysis.

INTRODUCTION: DPP-4 inhibitors use has been reported to cause heart failure events in patients with type-2 diabetes. The FDA had also issued warnings concerning increased risk of heart failure events ...

Hepatic Artery Doppler Haemodynamic Indices as Imaging Biomarkers of Disease Activity in Adults with Chronic Hepatitis B: Correlation with Viral Load and Serum Alanine Transaminase.

BACKGROUND: Hepatitis B is a common cause of chronic liver disease. Early features of fibrosis are detectable using ultrasound and Doppler imaging. AIMS: This study evaluated relationships between hep...