Molecular profiling of coronary stent testenosis: A systematic review and functional analysis of implicated genes.
BACKGROUND: Coronary stent restenosis occurs in approximately 5% of patients treated with drug-eluting stents (DES) and is associated with adverse clinical outcomes. Elucidating the genetic mechanisms...
Latent profile analysis and influencing factors of self-disclosure in patients after percutaneous coronary intervention for coronary heart disease: A cross-sectional study.
Self-disclosure influences psychological adjustment and disease management after percutaneous coronary intervention (PCI) for coronary heart disease (CHD), yet most evidence treats post-PCI patients a...
Integrative genetic analysis reveals shared genetic architecture underlying coronary artery disease, CT-Defined coronary atherosclerosis, and cardiometabolic risk factors.
Coronary artery disease (CAD), computed tomography-defined coronary atherosclerosis (CT-CA), and cardiometabolic risk factors (CMRFs) are epidemiologically intertwined, yet their shared genetic basis ...
Multiparametric Coronary CT Angiography-Derived Imaging Biomarkers for Risk Stratification in Nonobstructive Coronary Artery Disease: Incremental Prognostic Value in Patients with Diabetes.
Background: Patients with diabetes mellitus and nonobstructive coronary artery disease (NOCAD) may remain at increased cardiovascular risk despite the absence of flow-limiting stenosis. Quantitative c...
Enhanced Discrimination of Coronary Artery Disease Severity by Circulating Phoenixin-14: Evidence from a Clinical Laboratory Study.
Early identification of anatomically significant coronary artery disease (CAD) remains a major clinical challenge despite advances in cardiovascular diagnostics. Novel circulating biomarkers may impro...
Exploratory LC-MS/MS-Based Proteomic and Lipidomic Profiling of Plasma Samples from Premature Coronary Artery Disease Patients: A Pilot Study in a South Asian Population.
Premature coronary artery disease (PCAD) is a growing public health concern, especially in South Asia, where traditional risk factors fail to fully explain the increasing incidence of early-onset myoc...
Threonine in Coronary Artery Disease: Insights From Metabolic Syndrome Amino Acid Profiling.
BACKGROUND Metabolic syndrome (MeS) amplifies cardiovascular risk, but molecular markers that distinguish between MeS and coronary artery disease (CAD) remain limited. The aim of this study was to det...
[Expert advisory on screening and diagnosis of inflammatory risk in coronary artery disease].
冠心病是全球疾病负担最重和导致死亡的主要原因之一，在积极降脂治疗的背景下，炎症风险已被证实为冠心病患者心血管事件的重要预测因素。近年来，随着抗炎治疗临床证据的积累，尤其是秋水仙碱等药物在冠心病二级预防中获益已被确证，炎症管理正逐步成为冠心病综合防治的新方向。在此背景下，中华医学会心血管病学分会心血管免疫与炎症学组联合心血管指南与共识学组、动脉粥样硬化与冠心病学组、中华心血管病杂志编辑委员会，基于最...
[Optimized antithrombotic therapy for coronary artery disease: current status and future perspectives].
抗栓治疗是冠心病综合管理的核心环节，直接决定患者缺血与出血风险的平衡及远期临床预后。近年来，随着新药研发、治疗策略迭代与风险评估技术进步，冠心病抗栓治疗正从传统标准化方案转向精准化、个体化模式。该文围绕新型抗栓药物研发进展、抗栓治疗策略革新、缺血与出血风险预测模型构建等方面，系统梳理该领域现状，剖析关键挑战，并对未来发展方向进行述评，为临床实践与科学研究提供参考。.
Standardized Protocol for Intravascular Ultrasound-Guided Lithotripsy in Severely Calcified Coronary Lesions.
Severe coronary artery calcification poses a clinical challenge during percutaneous coronary intervention, significantly increasing the risk of stent underexpansion and subsequent adverse cardiovascul...
IUM-hybrid model for enhanced CAD diagnosis using deep learning and VS Grad-CAM visualization.
Coronary artery disease(CAD) is a serious health issue worldwide. Early identification of CAD is used to prevent several complications, such as myocardial infarction and unexpected death. In existing ...
UNICORN During Transcatheter Aortic Valve Replacement in Native and Bioprosthetic Aortic Valves: A Multicenter Study.
BACKGROUND: UNICORN (undermining coronary obstruction with radiofrequency "needle") has been adopted by some operators to prevent coronary obstruction during transcatheter aortic valve replacement (TA...
Leaflet Modification to Mitigate Coronary Obstruction Risk During TAVR: Results From the LOFTER-TAVR Registry.
BACKGROUND: Coronary obstruction (CO) is a rare but life-threatening complication of transcatheter aortic valve replacement (TAVR). Leaflet modification techniques have been developed to mitigate this...
Joint Impact of Triglyceride-glucose Index and Free Fatty Acid Levels on Cardiovascular Outcomes in Overweight or Obese Patients with Coronary Artery Disease - A Large Multicenter Prospective Study.
OBJECTIVE: To investigate the joint effect of free fatty acid (FFA) and the triglyceride-glucose (TyG) index on the prognosis of overweight and obese coronary artery disease (CAD) patients. METHODS: A...
Prognostic value of dobutamine stress echocardiography: A South African experience.
BACKGROUND: Dobutamine stress echocardiography (DSE) is a well-established modality for the diagnosis and risk-stratification of coronary artery disease, but no prognostic data have been reported from...
Omentin-1 Val109Asp polymorphism and increased coronary artery disease risk in smokers with type 2 diabetes.
Omentin-1 protein has protective effects against coronary artery disease (CAD). The Val109Asp polymorphism (rs2274907) in the Omentin-1 gene has been associated with CAD risk, but this relationship ha...
Tenascin-C Drives Inflammatory VSMC Phenotypic Switching Through NF-κB Signaling in Saphenous Vein Graft Restenosis.
Vein graft restenosis is a leading cause of long-term failure after coronary artery bypass grafting (CABG), driven by maladaptive vascular smooth muscle cell (VSMC) responses to arterialization-induce...
Investigating the Impact of Continuing Care Model on Quality of Life and Cardiac Function in Patients With Coronary Heart Disease.
AIMS/BACKGROUND: The transition from hospital to home is a critical period for patients with coronary heart disease (CHD), and inadequate post-discharge care can adversely affect recovery. Continuing ...
The Association Between Glycemic Disorders and Acute Coronary Syndrome: Plaque Vulnerability in Perimenopausal and Post-Menopausal Women With Diabetes.
AIMS/BACKGROUND: Type 2 diabetes mellitus (T2DM) is a well-established risk factor for acute coronary syndrome (ACS). However, the association between prediabetes and ACS remains less clearly characte...
Machine Learning-Driven Prediction of Coronary Artery Disease Risk Based on UK Biobank Plasma Proteomics.
BACKGROUND: Coronary artery disease (CAD) is a leading global cause of mortality, yet the predictive accuracy of conventional risk models is limited. Here, we integrate conventional risk factors, poly...