Non-steroidal anti-inflammatory drug use in patients with varying severity of coronary artery disease.

PURPOSE: We examined temporal trends in NSAID use among patients referred for evaluation of suspected coronary artery disease (CAD). METHODS: We conducted a drug utilisation study using population-bas...

Coronary angiography findings in emergency department chest pain patients undergoing angiography despite hs-cTnT-based early rule-out angiography after hs-cTnT rule-out in ED chest pain.

BACKGROUND: High-sensitivity cardiac troponin (hs-cTn) algorithms are established for early rule-out of acute myocardial infarction, but coronary angiographic (CAG) findings in emergency department (E...

Coronary Artery Disease in Women: Sex-Specific Pathophysiology, Risk Factors, Clinical Presentation and Management.

Cardiovascular disease remains the leading cause of mortality among women worldwide, yet coronary syndromes in women continue to be under-recognized and insufficiently represented in clinical research...

Clinical, procedural and patient-reported outcomes of the Ultimaster Nagomi sirolimus-eluting coronary stent in complex percutaneous coronary intervention: the NAGOMI COMPLEX prospective cohort study protocol.

INTRODUCTION: Percutaneous coronary intervention (PCI) has evolved significantly over the past decade with approximately 30% of patients presenting with complex coronary artery disease, posing heighte...

Perceptions and experiences of patients with stable coronary heart disease participating in shared decision-making: a qualitative study in China.

OBJECTIVES: To explore, from the perspective of patients with stable coronary artery disease (SCAD), their perspectives and experiences of shared decision-making (SDM) participation. DESIGN: A descrip...

Association Between Stress Hyperglycemia Ratio and Cardiovascular Outcomes in Patients Who Underwent Complex Percutaneous Coronary Intervention According to Different Glycemic Status.

BACKGROUND: Complex percutaneous coronary intervention is associated with higher risk of long-term worse cardiovascular outcomes than noncomplex procedures. Stress hyperglycemia ratio (SHR), a biomark...

Clinical Outcomes of Complete Revascularization in Acute Myocardial Infarction Patients With High Bleeding Risk and Multivessel Disease.

BACKGROUND: High bleeding risk (HBR) is associated with an increased risk of both ischemic and bleeding events and is known to have a worse prognosis than non-HBR in patients with acute myocardial inf...

Reevaluating the Use of Race/Ethnicity in the MESA Risk Score.

BACKGROUND: Cardiovascular disease risk scores are widespread in research and clinical settings. The MESA (Multi-Ethnic Study of Atherosclerosis) risk score estimates the 10-year risk of coronary hear...

Predicting Mortality After Percutaneous Coronary Intervention in a Multiethnic Southeast Asian Population: Insights From Machine Learning.

Ischemic heart disease remains a major contributor to mortality in Malaysia, with non-elective percutaneous coronary intervention (PCI) frequently performed in high-risk acute coronary syndrome (ACS) ...

Within-sibling attenuation of polygenic risk score accuracy: investigating the effects of principal component analysis, LD score regression, and mixed model association in the UK Biobank.

A central challenge in polygenic risk prediction is measuring and controlling for confounding due to population stratification. Standard approaches include adjusting for leading principal components (...

Extracellular Traps in Coronary Thrombus Aspirates from Patients with ST-Elevation Myocardial Infarction.

The formation of extracellular traps (ETs) through ETosis has emerged as a key mechanism in immunothrombosis. However, the temporal dynamics and clinical significance of ETosis in coronary thrombi of ...

Leisure screen time, cardiometabolic pathways, and frailty: A two-step Mendelian randomization analysis.

Whether leisure screen time (LST) is causally related to frailty remains uncertain. We used Mendelian randomization (MR) to examine the association of genetically proxied LST with frailty risk and to ...

Association between blood cadmium and prevalent coronary heart disease in NHANES 2013 to 2014: A cross-sectional study with machine-learning analyses.

Cadmium is a toxic environmental metal, but its association with prevalent coronary heart disease (CHD) remains uncertain. We examined whether blood cadmium concentrations were associated with prevale...

Association between the Dietary Index for Gut Microbiota and all-cause mortality in coronary heart disease: A retrospective cohort analysis of NHANES (2005-2018).

The Dietary Index for Gut Microbiota (DI-GM) is a novel metric assessing diet quality in relation to gut microbial composition. However, its association with all-cause mortality (ACM) in coronary hear...

Endodontic status of patients with coronary atherosclerosis: A cross-sectional study.

BACKGROUND: There are no studies in the Colombian population assessing the prevalence and severity of apical lesions (ALs), or the relationship between the frequency and quality of endodontic treatmen...

Ethnicity-specific polygenic risk score for predicting coronary heart disease mortality in Malaysian patients with type 2 diabetes.

INTRODUCTION: Polygenic risk scores (PRS) are used to aggregate single-nucleotide polymorphisms (SNPs) effects across the genome to estimate an individual's risk of coronary heart disease (CHD). Howev...

Clinical characteristics and outcomes of myocardial infarction, stroke, and cardiovascular mortality among patients undergoing complex high-risk indicated percutaneous coronary intervention: A one-year review in a single non-surgical centre.

INTRODUCTION: Complex High-risk Indicated Percutaneous Coronary Intervention (CHIP-PCI) addresses complex coronary artery disease in patients unsuitable for or declining surgery. Performing CHIP-PCI i...

Association between frailty and clinical outcomes in critically ill coronary artery disease patients: A retrospective cohort study.

ObjectiveFrailty is prevalent in cardiovascular disease but lacks objective assessment tools in critical care. This study evaluated the association between the Frailty Index based on laboratory data (...

Monocyte-to-HDL-cholesterol ratio and 1-year mortality in critically ill coronary heart disease: A MIMIC cohort study.

ObjectiveThe monocyte-to-high-density lipoprotein cholesterol ratio (MHR) integrates inflammatory burden with anti-inflammatory lipid status, yet its prognostic value for long-term outcomes in critica...

Acute Coronary Syndrome Linked to Massive Coronary Artery Aneurysms as Late Complications of Kawasaki Disease: A Case Report.

Kawasaki disease (KD) is an acute childhood vasculitis that may cause late coronary complications. We report a 25-year-old man with childhood KD who presented with acute coronary syndrome without conv...