Artificial Intelligence-Driven Fractional Flow Reserve Assessment: Technical Foundations, Clinical Insights, and Future Directions.

Coronary artery disease (CAD) remains a leading cause of global morbidity and mortality. Accurate diagnosis of ischemia-causing coronary stenoses is essential for guiding revascularization and improvi...

The pro-apoptotic GZMB and anti-apoptotic HAX-1 and DAD-1 genes and gene proteins in human right auricular tissue affected by coronary heart disease and aortic valve stenosis: a pilot study.

The anti-apoptotic genes DAD-1 and HAX-1 and the pro-apoptotic GZMB gene have a significant role in the regulation of apoptosis in heart tissue. However, investigation into these genes and their prote...

The association of triglyceride-glucose index with acute myocardial infarction and all-cause mortality in patients with coronary artery disease stratified by acute myocardial infarction status: a large-scale retrospective cohort study from South China.

OBJECTIVES: This study aimed to investigate the association of the triglyceride-glucose (TyG) index with the risk of acute myocardial infarction (AMI) and all-cause mortality in patients with coronary...

Comparison of Leaflet Modification Techniques for TAV-in-TAV: Insights From Bench Testing.

BACKGROUND: Transcatheter aortic valve (TAV) leaflet modification can reduce the risk for coronary obstruction caused by the leaflet neoskirt created during TAV-in-TAV procedures. OBJECTIVES: The aim ...

Leaflet Splitting to Prevent TAVR-Induced Coronary Obstruction in Stented vs Stentless Surgical Bioprosthetic Valves.

BACKGROUND: Transcatheter electrosurgical leaflet splitting prevents coronary artery obstruction (CAO) following transcatheter aortic valve replacement (TAVR), particularly in valve-in-valve intervent...

Aortic Valve Leaflet Modification: A Working Group Position Statement on Best Practices and Step-by-Step Guide.

Coronary artery obstruction is a potential life-threatening complication of transcatheter aortic valve replacement (TAVR) in all settings including native, valve-in-valve, and redo-TAVR. Risk of obstr...

Prognostic value of stress perfusion cardiac magnetic resonance in patients with known or suspected coronary artery disease and supranormal left ventricular ejection fraction.

BACKGROUND: Prior studies have shown that a supranormal range of left ventricular ejection fraction (LVEF) is associated with adverse cardiovascular outcomes. However, the prognostic value of stress p...

Ginsenoside Rh2 Regulates PI3K/AKT Signaling, Metabolic Pathways, and the Gut Microbiota for Coronary Heart Disease Therapy.

This study investigated the molecular mechanisms underlying the therapeutic effects of ginsenoside Rh2 (G-Rh2) in coronary heart disease (CHD) through a network pharmacology approach, focusing on iden...

Relationship between C-reactive protein-to-albumin ratio and new-onset coronary artery disease and its severity in different glucose metabolic states: A retrospective cohort study.

The C-reactive protein-to-albumin ratio (CAR) integrates inflammatory and nutritional status.The study aimed to explore the potential connection between CAR and new-onset coronary artery disease (CAD)...

A cross-sectional study on the prevalence of cardiometabolic diseases and their multilevel socioeconomic impacts in Qianxinan Buyi and Miao Autonomous Prefecture, Southwest China.

Cardiometabolic diseases (CMDs) have become the leading cause of mortality and disease burden in low- and middle-income regions, including ethnic minority areas in southwest China. However, population...

Association between coronary artery disease and viral hepatitis: Perspectives based on the 2017-2018 National Health and Nutrition Examination Survey and Mendelian randomization analyses.

Coronary artery disease (CAD) is one of the leading forms of cardiovascular disease in Europe and the primary cause of death in the region, while millions of individuals in Europe remain chronically i...

Echocardiographic evaluation of right ventricular function before and after percutaneous coronary intervention in patients with coronary artery disease and pulmonary hypertension: A single-center retrospective cohort study.

Right ventricular (RV) dysfunction in patients with coronary artery disease (CAD) and concomitant pulmonary hypertension (PH) is associated with poor outcomes, yet its short-term reversibility after p...

Explainable machine-learning model for coronary artery disease diagnosis in non-AMI patients: integrating inflammatory and traditional risk factors.

OBJECTIVE: To develop and interpret an explainable machine learning (ML) model integrating inflammatory biomarkers and traditional risk factors for the diagnosis of coronary artery disease (CAD). METH...

Can obstructive peripheral arterial disease be a marker for coronary artery disease in patients with diabetic foot ulcers?

OBJECTIVE: Diabetic foot ulcers (DFUs) are a serious complication of diabetes that is often associated with peripheral arterial disease (PAD). Although PAD is associated with poor wound healing and a ...

Mai Guan Fu Kang capsule attenuates coronary heart disease via PI3K/Akt signaling pathway and gut microbiota.

OBJECTIVE: To investigate the therapeutic mechanism of Mai Guan Fu Kang Capsule (MGFKC) against coronary heart disease (CHD). METHODS: MGFKC constituents were identified by liquid chromatography-mass ...

Cardiac Biomarkers to Refine Pretest Probability for Coronary Obstruction and Predict Survival After Revascularization in Chronic Coronary Syndrome.

BACKGROUND: The diagnostic and prognostic roles of cardiovascular biomarkers in chronic coronary syndrome remain unclear. METHODS: Patients undergoing coronary angiography for suspected chronic corona...

Real-World Usage of a Paclitaxel-Coated Balloon With Urea Compared With Other Contemporary Drug-Coated Balloons: A 2-Year Analysis From SCAAR in Over 6000 Patients.

BACKGROUND: Drug-coated balloons (DCB) are frequently used during percutaneous coronary intervention. Despite this there are limited data from studies comparing different types of DCB, particularly fo...

Primary prevention of coronary heart disease in women.

Coronary heart disease (CHD) is a leading cause of death in women. Observational studies have consistently shown estrogen to help prevent CHD in postmenopausal women. The large randomised controlled W...

Breaking The Stone: Stentless Coronary Revascularization with Intravascular Lithotripsy and Drug-Coated Balloon Technology Guided by IVI.

Background: Severe coronary calcification remains a major challenge in percutaneous coronary intervention (PCI), often complicating lesion preparation and stent expansion. Intravascular lithotripsy (I...

Machine Learning Multiorgan Analysis of Coronary CT Angiography Body Composition, Myocardial Infarction, and Mortality in the SCOT-HEART Trial.

Background Coronary CT angiography provides prognostic information in addition to coronary findings. Purpose To evaluate associations between machine learning-derived multiorgan body composition and 1...