Expanding access to vascular care using BlueDop Vascular Expert: an artificial intelligence-driven diagnostic tool.

OBJECTIVE: This study aimed to evaluate and compare the screening capabilities of BlueDop Vascular Expert (BVE; BlueDop Medical Ltd., UK) and the ankle-brachial index (ABI) in detecting peripheral art...

Management of Large Artery Atherosclerosis.

OBJECTIVE: Large artery atherosclerosis is a common cause of ischemic stroke and transient ischemic attack and presents a high-risk condition for recurrent strokes. This article provides clinicians wi...

Ferulic Acid Suppresses Diabetes-Induced Atherosclerosis by Targeting Oxidative Stress, NF-κB p65/iNOS, and miRNAs Pathways.

Atherosclerosis, a major complication of diabetes mellitus, involves complex metabolic and inflammatory disruptions that remain inadequately addressed by current therapies. Ferulic acid (FA), a plant-...

Circulating Human Epididymis Protein 4 Predicts 10-Year Mortality and Major Adverse Cardiovascular Events in Patients With Peripheral Artery Disease.

BACKGROUND: Human epididymis protein 4 (HE4) has emerged as a biomarker linked to fibrosis and cardiovascular disease. However, its prognostic relevance in peripheral artery disease (PAD) remains uncl...

Ligand-Independent Activation of Notch1 by Cathepsin L Induces CUX1/p16(INK4a)-Dependent Endothelial Senescence Associated With Atherosclerosis.

Our post-GWAS functional analysis revealed that cathepsin L (CTSL) is an upstream regulator of CUX1, and it induces p16INK4a-dependent and atherosclerosis-associated senescence by indirectly activatin...

Current Status and Associated Factors of Discharge Readiness in Lower Extremity Peripheral Artery Disease Patients: A Cross-Sectional Study.

This study investigated the current readiness for hospital discharge (RHD) among patients with lower extremity peripheral arterial disease (PAD) following endovascular revascularization within an enha...

Exercise Improves Atherosclerotic Plaque Stability Through Macrophage Autophagy and the FGF21 Signaling Pathway.

Atherosclerosis (AS) is a major driver of acute cardiovascular events, yet the mechanisms by which exercise stabilizes atherosclerotic plaque remain poorly understood. This study investigated the prot...

Isolation, Synthesis, and Characterization of CD47- and Integrin α4/β1-Modified Macrophage Membrane-Coated Poly(lactic-co-glycolic acid) Nanoparticles.

Atherosclerosis is a chronic inflammatory disease and a major contributor to cardiovascular morbidity and mortality. Targeted delivery of anti-inflammatory agents to atherosclerotic sites remains a si...

EZH2 inhibition via GSK-126 mitigates EndMT and atherosclerosis in diabetes: A translational epigenetic approach.

Atherosclerosis drives cardiovascular morbidity in diabetes, with endothelial-to-mesenchymal transition (EndMT) as a key contributor. Whereas epigenetic regulators are increasingly implicated in ather...

[Dual role and therapeutic potential of TREM2 in atherosclerosis].

Triggering receptor expressed on myeloid cells 2 (TREM2) is a key transmembrane immune receptor that is specifically highly expressed in myeloid cells, particularly macrophages, within atherosclerosis...

Patient Engagement Strategies for Implementing Evidence-Based Care in Atherosclerosis.

PURPOSE OF THE REVIEW: Despite continuing therapeutic advances in cardiovascular disease, it remains a leading cause of morbidity and mortality in the US. The current challenge is not the development ...

Intervening at the microbial crossroads: targeting inflammation across the oral-gut-reproductive microbiome crosstalk in atherosclerosis.

Despite the increasing burden of mortality due to cardiovascular disease, the traditional risk factors fail to explain the complexity of the pathology of cardiovascular disease, especially in the cont...

Role of Inflammatory Biomarkers in Peripheral Arterial Disease: A Comprehensive Review of Prognostic and Therapeutic Implications.

Background: Peripheral artery disease (PAD) is a manifestation of systemic atherosclerosis characterized by chronic inflammation, endothelial dysfunction, and high residual risk of major adverse cardi...

Towards Neoatherosclerosis: A Porcine Model for Enhanced Device Testing.

The porcine in-stent stenosis model has been essential for developing drug-coated devices but does not replicate the hyperlipidemic, pro-atherogenic conditions driving neoatherosclerosis. We aimed to ...

Vascular Aging and Atherosclerosis: The Modulatory Impact of Selenium-A Comprehensive Review.

Selenium (Se), a vital trace element, plays a significant role in maintaining vascular health and may offer protective effects against atherosclerosis. Its actions are mediated through Se-dependent se...

Exploring the Toxicological Relationship Between Diisononyl Cyclohexane-1,2-dicarboxylate and Atherosclerosis Through Network Toxicology, Machine Learning, and Multi-Dimensional Bioinformatics.

This study integrates multidimensional computational approaches-network toxicology, machine learning, molecular docking, and molecular dynamics simulation-to systematically elucidate the toxic mechani...

miRNA-26b Is Associated with Increased Connexin-40 Expression in Endothelial Cells Under Flow Conditions.

Endothelial cell dysfunction is the initial step in atherosclerosis, in which gap junction proteins such as connexin 40 (Cx40) might play an important role. Previously, we could demonstrate that miRNA...

[Establish a Zebrafish Atherosclerosis Model Screening Platform to Evaluate the Therapeutic Effects of Qi-Regulating and Blood-Activating Prescriptions on Atherosclerosis].

OBJECTIVE: To systematically identify traditional Chinese medicine (TCM) compound formulas with anti-atherosclerosis (AS) potential using a screening platform based on multi-strain apoeb gene knockout...

[Study on the Mechanism by Which Atorvastatin Enhances the Stability of Atherosclerotic Plaques in ApoE(－/－) Mice Through Regulation of MMP-7/Gα13].

OBJECTIVE: To explore the pleiotropic molecular mechanisms by which atorvastatin (Ator) regulates atherosclerosis (AS) in ApoE－/－ mice. METHODS: Thirty 8-week-old male ApoE－/－ mice were induced to dev...

LRG1 as a Potential Therapeutic Target in Atherosclerosis: Mechanistic Basis and Current Evidence.

Atherosclerosis (AS) is a chronic inflammatory disease of large arteries. It underlies many cardiovascular disorders, including coronary artery disease, myocardial infarction, stroke, and peripheral a...