Automated Daily Phone Surveys in Older Adults: Feasibility Study in the Multi-Ethnic Study of Atherosclerosis.

BACKGROUND: An ecological momentary assessment (EMA) is a methodological framework designed to capture real-time data in a participant's natural environment, yet its feasibility in older adults, parti...

A controlled-release mitochondrial protonophore attenuates early- and late-stage atheroprogression in mice.

Atherosclerotic cardiovascular disease (ASCVD) remains a leading cause of morbidity and mortality in patients with insulin resistance, and new therapies are urgently needed. We previously developed an...

SEC16B identified as a regulator of VLDL secretion and lipid accumulation in the liver.

The liver plays a major role in regulating the metabolic fate of lipids and facilitates lipid secretion to peripheral organs in the form of VLDLs or lipid storage in lipid droplets (LDs). Hepatic regu...

Associations Between Welding-Related Metals and Atherosclerotic Cardiovascular Disease Risk in Male Welders: The Mediating Role of Accelerated Biological Aging.

The impact of metals on atherosclerotic cardiovascular disease (ASCVD) risk in workers occupationally exposed to welding fume remains unclear. We aimed to assess the associations between welding-relat...

miR-187-3p as a Biomarker for Ischemic Stroke and the Therapeutic Target for Atherosclerosis via LOX-1 Inhibition.

As the primary receptor of oxidized low-density lipoprotein (ox-LDL), LOX-1 is a putative therapeutic target for atherosclerotic disorders including ischemic stroke (IS), whereas the regulatory mechan...

m6A-Modified KLF11 Inhibits Macrophage Foam Cell Formation by Transcriptionally Suppressing ATP5B Expression in Atherosclerosis.

Macrophage foam cell formation is the mark of atherosclerosis (AS). Krüppel-like factor (KLF)11 prevented the development of AS in diabetic conditions. However, it is not clear whether KLF11 inhibits ...

SENP3 Deficiency Inhibits Atherosclerosis by Regulating TLR4/NF-κB and SOAT2.

SUMOylation plays critical roles in both initiation and development of atherosclerosis. SUMO-specific protease 3 (SENP3), a SUMO-specific protease that targets SUMO2/3 for deSUMOylation, is involved i...

Octacosanol: A Natural Bioactive Ingredient for Atherosclerosis Prevention and Cardiovascular Health Promotion.

Cardiovascular diseases remain the top cause of death worldwide, with atherosclerosis as a key underlying factor. Natural bioactive ingredients from functional foods are increasingly sought after for ...

Arginase-2 enhances monocyte-endothelial interaction through regulation of integrin and membrane receptor expression: role in atherogenesis.

BACKGROUND: Circulating monocyte trans-endothelial migration is critical for vascular diseases. The monocyte surface proteins, i.e., integrins and membrane receptors are central in this process. Previ...

Curcumin in Atherogenic Dyslipidemia: Linking Preclinical Mechanistic Insights to Clinical Outcomes.

Background/Objectives: Atherogenic dyslipidemia is a major cardiometabolic risk factor characterized by elevated circulating triglycerides (TGs), reduced HDL-C, and increased levels of atherogenic lip...

The Neuroimmune Mechanisms Linking Smoking and Infection to Atherosclerosis: Chronic vs. Surge.

The pathogenesis of atherosclerosis has progressively shifted from a lipid-centric model to one that recognizes inflammation as the central driver. Smoking is a well-established chronic risk factor, w...

Extreme atherogenic index of plasma (log[TG_max/HDL_min]) and prognosis in sepsis-associated acute kidney injury: A MIMIC-IV retrospective study.

Sepsis-associated acute kidney injury (SA-AKI) substantially worsens clinical outcomes, yet reliable prognostic biomarkers remain limited. Dysregulation of lipid metabolism, particularly elevated trig...

Colchicine enhances macrophage cholesterol efflux by targeting DTL-mediated ubiquitination and degradation of ABCA1.

OBJECTIVE: This study aims to elucidate the potential pharmacological mechanisms by which colchicine confers clinical benefits in patients with atherosclerotic cardiovascular disease, focusing on its ...

Endothelial cannabinoid CB1 receptor deficiency reduces shear stress-induced arterial inflammation and lipid uptake.

Peripheral cannabinoid CB1 receptor antagonists that lack central nervous system effects are emerging as promising therapies for metabolic disease, yet the role of endothelial CB1 signaling in atheros...

EAT-Lancet Diet, Plasma Metabolites, and Risk of Peripheral Artery Disease: A Prospective Cohort Study.

BACKGROUND: The Planetary Health Diet Index, developed by the EAT-Lancet Commission, promotes sustainable and healthy eating, yet its association with peripheral artery disease (PAD) remains underexpl...

Metabolic and Safety Outcomes of Statin-Ezetimibe Versus High-Intensity Statin in Older Patients.

BACKGROUND: High-intensity statins are recommended for secondary prevention in atherosclerotic cardiovascular disease (ASCVD), but older adults frequently experience tolerability issues and adverse me...

Lesion Morphology and Technical Success in Diabetic vs. Non-Diabetic Patients with Chronic Limb-Threatening Ischemia Undergoing Endovascular Treatment: A Retrospective Single-Center Study.

Background and Objectives: Chronic limb-threatening ischemia (CLTI) represents the most advanced stage of peripheral arterial disease and is associated with an increased risk of major amputation, part...

Imaging and Molecular Biomarkers of PFAS-Related Vascular Aging: A Narrative Review.

Per- and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants increasingly associated with cardiovascular disease. Identifying early manifestations of vascular aging before the ...

The AS-PAD Score Predicts Significant Peripheral Artery Disease and Is Associated with Femoral Access-Site Closure Device Failure in Patients Undergoing TAVI.

Background and Objectives: Patients with severe aortic stenosis (AS) frequently present with concomitant peripheral artery disease (PAD), which complicates transcatheter aortic valve implantation (TAV...

Endovascular Intervention and the Vascular Glycocalyx in Patients with Chronic Limb-Threatening Ischaemia: A Prospective Observational Study.

This single-center prospective observational study evaluated peri-procedural changes in circulating markers of endothelial glycocalyx injury in patients with chronic limb-threatening ischemia undergoi...