Targeting LDL Across the Whole Spectrum of Chronic Kidney Disease: From Pathophysiology to Novel Treatments.
PURPOSE OF REVIEW: The natural fate of chronic kidney disease (CKD) is the progression to dialysis; however, most patients face fatal and nonfatal cardiovascular events throughout their lifetime. We h...
The fate of the contralateral limb after major lower limb amputation for peripheral arterial disease or diabetes mellitus.
BACKGROUND: The contralateral limb is at risk after major lower limb amputation (MLLA) for peripheral arterial disease or diabetes mellitus due to the systemic nature of these diseases, with a subsequ...
Socioeconomic, ethnic and geographical disparities in revascularization rates for peripheral arterial disease in England.
BACKGROUND: There are disparities in the prevalence of peripheral arterial disease (PAD). This study examined socioeconomic, ethnic, and geographical variations in population-based revascularization r...
Shanhuang Jiangzhi tablets mitigate atherosclerosis by modulating macrophage polarization and inhibiting foam cell formation via the ROS/TLR4/NF-κB pathway.
OBJECTIVES: Atherosclerosis significantly contributes to global cardiovascular mortality. Macrophage polarization and foam cell formation via oxidized low-density lipoprotein uptake are key drivers of...
Gut Microbiota and Atherosclerotic Plaque Instability: Cellular and Molecular Mechanisms.
Atherosclerosis is a chronic multifactorial inflammatory vascular disease and the major risk factor for cardiovascular diseases (CVDs), characterized by arterial wall thickening, loss of arterial elas...
Follistatin Mitigates Atherosclerosis Through Activation of Arginine Metabolism and Adipose Browning.
Follistatin (FST) binds to and neutralizes members of the transforming growth factor-beta (TGF-β) superfamily, thereby regulating diverse physiological processes, including regulation of skeletal musc...
The correlation between impaired thyroid hormone sensitivity and 10-year atherosclerotic cardiovascular disease (ASCVD) risk score in patients with type 2 diabetes mellitus.
BackgroundAtherosclerotic cardiovascular disease (ASCVD) is one of the common complications in patients with type 2 diabetes mellitus (T2DM). Thyroid hormones affect cardiovascular function through mu...
The diagnosis and current treatment of chronic lower extremity arterial disease.
Chronic lower extremity arterial disease (PAD) can be categorized into three subsets: Asymptomatic PAD, Chronic Symptomatic PAD, and Chronic Limb Threatening Ischemia (CLTI). Symptoms, signs and treat...
Efficient estimation for deep generalized accelerated hazards models with interval-censored data.
For the analysis of interval-censored data, we propose a deep generalized accelerated hazards model. This model is designed to facilitate a detailed exploration of the relationship between various ris...
[Effects of Zuopi Pills on ApoE~(-/-) atherosclerotic mice by inhibiting ferroptosis via ACSL4/LPCAT3/ALOX15 pathway].
This study integrated network pharmacology, computational simulation, spatial transcriptomics, and animal experiments to systematically reveal the multi-level mechanism of the traditional Chinese medi...
Analysis of the diabetic arterial transcriptome to define novel biomarkers of macrovascular disease.
Diabetes mellitus (DM) approximately doubles the risk of atherosclerotic cardiovascular disease (ASCVD) events, but the molecular basis is poorly understood. Using RNA-sequencing data from two arteria...
Cell-Type-Specific Regulation of Ferroptosis in Atherosclerosis: Mechanisms and Therapeutic Potential of Natural Products.
Ferroptosis is a regulated form of cell death in which disturbed iron metabolism, accumulation of peroxidized membrane lipids, and insufficient glutathione peroxidase 4 (GPX4) activity converge to inj...
Adverse pregnancy outcomes and long-term risk of peripheral artery disease: A cohort study.
BACKGROUND: Women with adverse pregnancy outcomes have higher subsequent cardiovascular risks, but their long-term risks of peripheral artery disease (PAD) and potential causality are unclear. A bette...
Atherogenic Index of Plasma for the Prediction of Delirium in ICU Patients: A Retrospective Cohort Study Based on the MIMIC-IV Database.
BACKGROUND: This cohort study aimed to assess the association between atherogenic index of plasma (AIP) and the risk of delirium in intensive care unit (ICU) patients. METHODS: Using the Medical Infor...
Inflammation and atherosclerotic cardiovascular disease: lights and shadows.
Atherosclerosis as an inflammatory process has been a Leitmotiv in cardiology for the past 30 years, and the hypothesis of a causal role has now been tested in several clinical trials aimed at demonst...
Admission Phenotype Clarifies the Apparent Prognostic Contrast Between TOAST Etiologic Subtypes in Large-Core Anterior-Circulation Large-Vessel Occlusion.
OBJECTIVE: In large-core anterior-circulation large-vessel occlusion (LVO), differing admission clinical-imaging profiles complicate interpretation of prognostic differences between large-artery ather...
Atherosclerotic Cardiovascular Disease and Cancer.
Atherosclerotic cardiovascular disease (ASCVD) and cancer are increasingly recognized as interconnected diseases linked by shared immune mechanisms rather than merely overlapping risk factors. Common ...
Precision medicine for atherosclerotic cardiovascular disease: Integrative genomics maps risk loci and AI-predicted functional consequences.
BACKGROUND: Atherosclerotic cardiovascular disease (ASCVD) is a leading cause of global morbidity and mortality, but its genetic architecture remains incompletely understood. This study aims to uncove...
The Triglyceride-Glucose Index Combined With Obesity Indices and Lower Extremity Artery Disease in Type 2 Diabetes: A Sex-Stratified Analysis.
BACKGROUND: Lower extremity artery disease (LEAD) is highly prevalent among people with type 2 diabetes mellitus (T2DM) in China. This study aimed to investigate the associations of the triglyceride-g...
Conditional knockout of membrane-type I matrix metalloproteinase in smooth muscle cells of adult mice alleviates atherosclerosis without affecting basic cardiovascular function.
BACKGROUND: Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of morbidity and mortality worldwide. Despite effective lipid-lowering treatments, substantial residual risks remain. In...