Biomarkers for Diabetic Peripheral Artery Disease: An Integrated Review and Clinical Perspective.
Type 2 diabetes mellitus and peripheral artery disease are pathophysiologically interlinked through shared mechanisms such as chronic inflammation and endothelial dysfunction, highlighting the imperat...
Perfluorooctane Sulfonate Exposure and Peripheral Artery Disease: Mendelian Randomization and Integrative Multi-Omics Systems Toxicology With Machine Learning.
Epidemiological and experimental studies have linked legacy and emerging PFAS to adverse cardiovascular outcomes, yet most evidence remains observational and is susceptible to confounding, measurement...
Identification of PRKCB, NLRC4, and TNFSF10 as Key Regulators of the Lipid Metabolism-Autophagy Network in Atherosclerosis.
BACKGROUND: The occurrence and development of atherosclerosis (AS) are closely related to disorders of lipid metabolism and dysfunction of autophagy. However, the key regulatory genes and immune micro...
Polygenic Risk Scores for Incident Dementia in the Multi-Ethnic Study of Atherosclerosis.
Over 75 Alzheimer's disease (AD) and dementia-associated variants have been identified through genome-wide association studies, but the utility of polygenic risk scores (PRS) for predicting AD and dem...
Mex-3 RNA-binding family member A limits macrophage ferroptosis-associated injury linked to the SLC7A11/GPX4 pathway in diabetic atherosclerosis.
BACKGROUND: Diabetes accelerates atherosclerotic plaque expansion and loss of stability, but the plaque-resident mechanisms through which the diabetic milieu promotes macrophage lipid-oxidative injury...
Chronic Bladder Ischemia Enhances Mechanosensitive Afferent C-Fiber Activity: Insights From a Newly Developed Female Rat Model.
OBJECTIVES: This study aimed to develop and validate an atherosclerosis-induced chronic bladder ischemia (CBI) model in female rats and to evaluate mechanosensitive single-unit afferent activity (SAA)...
Association of fish intake with systemic immune-inflammation index: Potential mediating role of n-3 polyunsaturated fatty acids.
OBJECTIVE: Low inflammation associated with fish intake may reflect not only the amount of fish consumed but also its nutrient composition and related lifestyle factors. This study investigated the re...
Natural extracts for the treatment of atherosclerosis.
Atherosclerosis (AS) is a cardiovascular disease with high mortality and disability rates, and the increasing number of cases urgently demands more effective therapeutic options. AS is characterized b...
Special Issue "Atherosclerosis: From Molecular Biology to Therapeutic Perspective: 6th Edition".
Atherosclerosis remains a leading cause of morbidity and mortality worldwide, representing a complex and multifactorial disease at the intersection of aging, metabolism, inflammation, and environmenta...
Associations between atherogenic index of plasma and endometriosis: The National Health and Nutrition Examination Survey 1999 to 2006.
It has been proved that lipids have an effect on endometriosis, and the plasma atherosclerosis index (AIP), as a new lipid index, has not been proved to be correlative to endometriosis. The National H...
Lipid-Induced Endothelial Dysfunction: Pro-Atherogenic Properties of Multinucleated Variant Endothelial Cells.
Endothelial dysfunction is an early event in the development of cardiovascular diseases and is characterized by impaired barrier function, inflammatory activation of endothelial cells (ECs), and alter...
Guggulsterone Alleviates Atherosclerosis in ApoE(-/-) Mice by Modulating Lipid Metabolism and Inflammatory Responses Associated with Modulation of the Srebp2/Hmgcr Signaling Axis.
OBJECTIVE: Atherosclerosis (AS) is a chronic inflammatory vascular disease characterized by dysregulated lipid homeostasis and plaque formation. Consequently, there is an ongoing need for therapies wi...
N=1-studies In Statin-intolerance; Objectifying Nocebo Effects (NISONE): a study protocol for a randomised controlled trial assessing the implementability of N=1-studies to promote the use of statins.
INTRODUCTION: Lipid-lowering therapies, particularly statins, are central to the prevention of atherosclerotic cardiovascular disease. However, their effectiveness is often compromised by statin-assoc...
Avoidance of Major Amputation After Deep Vein Arterialization and Advanced Wound Management in a Patient with Diabetes and No Direct Revascularization Options: A Case Report.
Chronic limb-threatening ischemia (CLTI) in patients with no conventional targets for revascularization presents a formidable challenge in limb salvage. Deep venous arterialization (DVA) is an emergin...
Aortic Single-Cell Transcriptome Analysis Reveals ApoE-Isoform-Specific Influences on Vascular Disease.
The human APOE gene is polymorphic with three major alleles that encode apolipoprotein (apo) E2, apoE3, and apoE4. Both apoE2 and apoE4 are associated with increased atherosclerosis risk. This study u...
Equitable lipid optimisation through a data-driven, pharmacist-led secondary prevention pathway.
BACKGROUND: Atherosclerotic cardiovascular disease (ASCVD) is a leading cause of morbidity and mortality in the UK, with raised cholesterol contributing to 25%-28% of ASCVD deaths. Despite well-establ...
Vitamin D Status and Atherogenic Lipid Profiles, Including Lipoprotein(a), in Elite Athletes.
Background/Objectives: Vitamin D has been implicated in lipid metabolism, but data regarding its association with atherogenic lipoproteins in elite athletes remain limited. Elite athletes represent a ...
MLK3 promotes atherosclerosis by regulating ferroptosis in macrophages.
BACKGROUND: Atherosclerosis (AS) is the leading cause of cardiovascular death worldwide. Macrophage ferroptosis is implicated in AS progression. The precise mechanism by which mixed lineage kinase 3 (...
Study on diagnostic genes and immune microenvironment disorder in comorbid atherosclerosis and Alzheimer disease.
Atherosclerosis (AS) and Alzheimer disease (AD) are globally prevalent chronic diseases with challenges of difficult early diagnosis and a lack of effective combined therapies. This study explored the...
Selective Alterations of Thiol Redox Homeostasis and Antioxidant Enzyme Activity in Advanced Atherosclerosis.
Atherosclerosis is a progressive vascular disease characterized by lipid-rich plaque accumulation, oxidative stress, and chronic inflammation, contributing to coronary heart disease, stroke, and perip...