Single-cell Technologies in Atherosclerosis: Uncovering Cellular Heterogeneity, Mechanisms, and Therapeutic Opportunities.
PURPOSE OF REVIEW: This review highlights recent advances in single-cell analysis technologies and their application in clarifying the cellular and molecular complexity of atherosclerosis, redefining ...
Trefoil Factor 3 as a Biomarker for Peripheral Artery Disease.
BACKGROUND: While trefoil factor 3 (TFF3) has been linked to cardiovascular disease, its role in peripheral artery disease (PAD) remains largely unexplored. In this prospective study, we assessed thre...
Reducing Lower Extremity Amputations via Peer Support Interventions: A Scoping Review.
Patients with diabetes and/or peripheral artery disease (PAD) are at risk for lower limb amputation and a subsequently higher mortality risk. Peer support interventions have been shown to increase dia...
Research Progress on the Molecular Mechanism of LRP1 and TGFβ-PDGFRβ Signaling Network in Atherosclerosis and Vascular Remodeling.
Atherosclerosis (AS) is the primary underlying cause of cardiovascular and cerebrovascular diseases. The occurrence and development of AS are closely related to lipid deposition, chronic inflammation,...
Optimal Antithrombotic Therapy for Peripheral Artery Disease: A Systematic Review and Network Meta-Analysis.
BACKGROUND: The optimal antithrombotic regimen for peripheral artery disease, balancing thromboembolic and bleeding risks, remains uncertain. This study aimed to compare the efficacy and safety of ant...
Blood Levels of Angiotensinogen and Risk of Ischemic Stroke: The Multi-Ethnic Study of Atherosclerosis.
BACKGROUND: We investigated whether circulating angiotensinogen levels are associated with the risk of ischemic stroke and examined sex-specific differences. METHODS: We included 5622 participants (me...
The GNB3 C825T Polymorphism Is Associated With Decreased Risk of Recurrence of Large-Artery Atherosclerotic Acute Ischemic Stroke.
BACKGROUND: GNB3 C825T polymorphism affects G protein-coupled receptor signaling, influencing platelet function, inflammation, and cardiovascular risk. This study aimed to investigate the unknown effe...
Novel use of arm ergometry cardiopulmonary exercise testing for non-elective patients with chronic limb-threatening ischaemia: a feasibility trial.
OBJECTIVES: To evaluate the feasibility, safety and acceptability of arm crank ergometry cardiopulmonary exercise testing (CPETarm) in patients with chronic limb threatening ischaemia (CLTI). DESIGN: ...
Primary Prevention of Dyslipidemia: 10 Practice-Changing Takeaways from the 2026 ACC/AHA Multisociety Guideline.
PURPOSE OF REVIEW: Dyslipidemia remains a common and treatable risk factor for atherosclerotic cardiovascular disease (ASCVD) in the United States (US) and worldwide. In 2026, the American College of ...
Association Between Cirrhosis and Acute or Severe Limb Ischemic Events Among Hospitalizations with Peripheral Artery Disease: A National Inpatient Sample Analysis.
Background and Objectives: Acute or severe limb ischemic events are limb- and life-threatening complications of peripheral artery disease (PAD). Although cirrhosis is increasingly recognized as a syst...
The relationship between symptomatic lower extremity peripheral artery disease with carotid artery stenosis and ischemic stroke.
OBJECTIVE: The aim of this study was to investigate the prevalence of carotid artery stenosis (CAS) in peripheral artery disease (PAD) patients requiring surgical or interventional procedures, to exam...
Soluble CD146 reflects altered endothelial and metabolic homeostasis in peripheral artery disease.
BACKGROUND: Peripheral Arterial Disease (PAD) is a prevalent but underdiagnosed pathology. Soluble CD146 (sCD146) was described as a marker of endothelial dysfunction and vascular congestion. OBJECTIV...
Revolutionizing Sectioned Images of the Visible Korean: Achieving From 0.05 mm to 0.03 mm Sized Pixel.
BACKGROUND: The Visible Korean (VK) project aimed to overcome the limitations of traditional cadaver dissection by producing high-resolution sectioned images. This study compared a newly acquired 2024...
Micro-and Nano-Plastic Exposure as an Emerging Risk for Atherosclerotic Cardiovascular Disease.
PURPOSE OF REVIEW: This review examines micro- and nanoplastic (MNP) exposure as an emerging risk factor for atherosclerotic cardiovascular disease, focusing on how individual-level exposures shaped b...
Century of Progress on the Structure of APOB-100 in Atherogenic Lipoproteins.
APOB-100 (apolipoprotein B100) is the obligate structural protein of very low-density lipoprotein (VLDL), intermediate density lipoprotein, and low-density lipoprotein (LDL), with each atherogenic par...
Antibody E06 and the Role of Oxidized Phospholipids in Atherogenesis and Inflammation.
Oxidized phospholipids (OxPL) are generated at sites of oxidative stress and tissue injury, where they function as prototypic danger-associated molecular patterns that trigger inflammation, cell death...
Kidney-Vascular Metabolic Crosstalk: Altered Lipoproteins in CKD.
Cardiovascular disease and chronic kidney disease are highly interconnected, with declining kidney function markedly increasing cardiovascular risk. Chronic kidney disease profoundly disrupts lipoprot...
New and Emerging Therapeutic Targets for ApoB-Containing Particles Lowering.
ApoB is the structural protein of all atherogenic lipoproteins, including VLDLs (very-low-density lipoproteins), IDLs (intermediate-density lipoproteins), LDLs (low-density lipoproteins), chylomicron ...
Perfusion Parameters to Identify Acute Steno-occlusive Carotid Artery Disease Due to Atherosclerosis Prior to Endovascular Therapy.
BACKGROUND AND PURPOSE: Perfusion imaging is commonly utilized to assess collateral status in patients with acute ischemic stroke due to anterior large-vessel occlusion. However, its potential role in...
The Association Between Abnormal Electrocardiogram Findings and the Ankle Brachial Index.
Background and Objectives: Peripheral artery disease (PAD) is a common manifestation of systemic atherosclerosis associated with significant morbidity and mortality, yet it remains underdiagnosed due ...