The Complex Role of Methylation in Regulating Vascular Smooth Muscle Cell Phenotypic States in Vascular Remodeling and Atherosclerosis.

Vascular smooth muscle cell (VSMC) control of phenotypic states through regulation of contractile gene expression is critical for vascular homeostasis and for participation in pathological vascular re...

Anti-Inflammatory Interleukins in the Pathogenesis of Atherosclerosis.

In recent years, the study of interleukins (ILs), crucial cytokines involved in inflammation, has garnered significant attention within coronary artery disease including atherosclerosis. This review p...

Regional tissue oxygen saturation as an indicator of wound healing during endovascular treatment for chronic limb-threatening ischaemia.

OBJECTIVE: It is important to evaluate limb blood flow during the perioperative period to salvage affected limbs in patients with chronic limb-threatening ischaemia (CLTI). However, it is difficult to...

Metformin as a multi-target modulator of atherosclerosis: integrated regulation of Nrf2/KLF2, mitochondrial homeostasis, inflammation, ferroptosis, and innate immunity.

OBJECTIVES: Atherosclerosis (AS) is a chronic inflammatory vascular disorder driven by endothelial dysfunction, oxidative stress, lipid dysregulation, mitochondrial injury, and maladaptive immune acti...

[Mechanistic study of Scutellariae Radix against atherosclerosis through inhibition of pyroptosis based on network pharmacology and experimental verification].

This study systematically investigated the mechanism of Scutellariae Radix against atherosclerosis(AS) through the integrated application of network pharmacology, molecular docking, and animal experim...

[Mechanism study of Zhizi Dahuang Decoction in treating atherosclerosis based on network pharmacology, molecular docking, and experimental validation].

This paper investigated the effects and mechanisms of Zhizi Dahuang Decoction(ZZDHT) in treating atherosclerosis(AS) through a comprehensive approach combining network pharmacology, molecular docking,...

Effect of L‑arginine supplementation on homocysteine and asymmetric dimethylarginine in atherosclerotic lower limb ischemia.

Chronic lower limb ischemia is a manifestation of systemic atherosclerosis frequently accompanied by lipid metabolism disorders, endothelial dysfunction, and disturbances in the L-arginine-nitric oxid...

Targeting atherosclerotic inflammation: Advances in NLRP3 inflammasome inhibitors beyond LDL-C.

Atherosclerosis, the main pathological background of cardiovascular diseases, is not only characterized by lipid metabolism disorders but also chronic inflammation as a major driver of disease progres...

Plain balloon angioplasty +/- bare metal stenting versus drug-coated balloon angioplasty +/- bare metal stenting versus primary drug-eluting stenting in patients with chronic limb-threatening ischaemia: BASIL-3, an open-label, three-arm, randomised, multi-centre, phase 3 trial.

OBJECTIVES: To determine which primary endovascular revascularisation strategy represents the most clinical and cost-effective treatment for patients with chronic limb threatening ischaemia who requir...

[Research advances in the molecular mechanisms of microRNA-mediated macrophage lipid homeostasis and foam cell formation].

The progression of atherosclerosis (AS) is intrinsically associated with dysregulated lipid metabolism in macrophages, leading to the formation of foam cells. MicroRNA (miRNA) finely regulates the exp...

Emerging biomedical and pharmaceutical strategies for the treatment of atherosclerosis: from conventional lipid-lowering therapy to nanomedicine.

Atherosclerotic cardiovascular disease (ASCVD), including myocardial infarction and ischemic stroke, is a leading cause of death and disability worldwide and is expected to rise further by 2030. Once ...

A Review of Dietary and Nutritional Supplements Used to Promote Cardiovascular Health.

Cardiovascular disease is frequently diagnosed in birds that are presented to veterinary hospitals, and atherosclerosis is a common cardiovascular condition identified in postmortem evaluations of pet...

A new era in atherothrombosis.

Atherothrombosis is a complex vascular disorder in which a thrombus forms on a vascular lesion, typically following the disruption and/or erosion of an atherosclerotic plaque. Atherothrombosis is the ...

Can markers predict plaque vulnerability?

The concept of "vulnerable plaque" (VP) has been evolving since its introduction as an atherosclerotic plaque prone to cause cardiovascular events, such as myocardial infarction and stroke. Once defin...

Hematopoietic somatic mutations in atherosclerotic cardiovascular disease.

Age-related somatic mosaicism in the hematopoietic system is increasingly recognized as a risk factor for atherosclerotic cardiovascular disease. The most prominent example is clonal hematopoiesis of ...

The secretory PCSK family in cardiovascular disease and beyond.

It took >20 years to discover the family of proteases implicated in the activation and/or regulation of the activity of secretory proteins, including polypeptide hormones, growth factors and receptors...

FTO-Catalysed Demethylation of LUR1 mRNA Suppresses Macrophage Lipid Accumulation and Aortic Atherosclerosis.

Lipid deposition and foam cell formation drive atherogenesis. Lipid uptake regulator 1 (LUR1) and N6-methyladenosine (m6A) modification play key roles in systemic lipid homeostasis. Bioinformatic anal...

Lipoprotein(a) and Peripheral Artery Disease as Independent Predictors of Arterial Stiffness in Patients With Hypertension: A Single-Center Cross-Sectional Study.

Carotid-femoral pulse-wave velocity (cfPWV) is a marker of central arterial stiffness and an established predictor of cardiovascular risk in hypertension. Although elevated lipoprotein(a) [Lp(a)] conc...

Role of nursing in the assessment of Peripheral Artery Disease: Comparison of two ankle to arm Index methods in patients with Diabetes.

AIMS: To compare the clinical implications of the new International Working Group on the Diabetic Foot (IWGDF) criterion for calculating the ankle-brachial index (ABI), which uses the lowest systolic ...

Editor's Choice - Focused Update on Paclitaxel Coated Technologies, from the 2024 European Society for Vascular Surgery (ESVS) Guidelines on the Management of Asymptomatic Peripheral Arterial Disease and Intermittent Claudication.

OBJECTIVE: This focused update to the European Society for Vascular Surgery (ESVS) clinical practice guidelines (CPGs) on asymptomatic peripheral arterial disease and intermittent claudication (IC) pr...