Severe paravalvular leakage caused by delayed dislocation of valve prosthesis after transcatheter aortic valve replacement for rheumatic aortic valve disease: A case report.

RATIONALE: Among patients undergoing transcatheter aortic valve replacement (TAVR), serious perivalvular leakage (PVL) caused by valve dislocation is a rare but serious complication. PATIENT CONCERNS:...

Prognostic value of the platelet-to-lymphocyte ratio for recurrent hemoptysis following bronchial artery embolization in patients with ronchiectasis.

Hemoptysis is a potentially life-threatening complication commonly observed in patients with bronchiectasis, often necessitating bronchial artery embolization (BAE). However, recurrence following BAE ...

Diagnostic value of ileocolic artery and vein diameters in acute appendicitis: A retrospective observational study with contrast-enhanced computed tomography.

Acute appendicitis is a common surgical emergency characterized by right lower quadrant pain. This study investigated the diagnostic value of ileocolic artery (ICA) and ileocolic vein (ICV) diameters ...

Causal effects of atopic dermatitis and rosacea on ventricular structure and function: A Mendelian randomization study.

Rosacea and atopic dermatitis (AD) are 2 chronic inflammatory skin diseases. Studies have revealed that patients with rosacea and AD exhibit elevated risks of cardiovascular disease. However, the impa...

Best available evidence for the management of oxaliplatin-induced hypersensitivity reactions, with implications for hepatic arterial infusion chemotherapy (HAIC).

PURPOSE: Oxaliplatin is widely used to treat gastrointestinal and hepatobiliary cancers, yet hypersensitivity reactions (HSRs) remain a significant safety concern in oncology. Although international g...

Selective retinal arterial whitening in retinal astrocytic hamartoma in tuberous sclerosis.

This case report aims to describe and understand the mechanism behind the selective retinal arterial whitening in a case of retinal astrocytic hamartoma (RAH) associated with tuberous sclerosis comple...

A ciliated intravascular soft millirobot for multimodal in-flow collective manipulation.

The laminar nature of blood flow and the resulting boundary layer pose substantial challenges for transverse mass transport in blood vessels, limiting intravascular biomedical applications such as tar...

Integrated Multi-omics Reveals CDKN1A Suppression and Metabolic Regulation as Key Mechanisms of Huangqi Guizhi Wuwu Decoction Against Doxorubicin-Induced Cardiotoxicity.

The clinical utility of doxorubicin (DOX) is severely limited by dose-dependent cardiotoxicity, for which effective interventions remain scarce. Huangqi Guizhi Wuwu Decoction (HGWD) shows promising ca...

Feasibility of a novel multi-device robotic system for multiple neurointerventional procedures: pre-clinical validation in porcine models.

While the application of a robotic system in neurointerventional procedures has gained notable attention, the current robotic assistance is unsatisfactory. Therefore, we developed a novel robotic syst...

Left Ventricular Summit Ventricular Tachycardia Identified by Electrocardiographic Pattern Recognition and Managed With Radiofrequency Ablation.

BACKGROUND Left ventricular summit ventricular tachycardia (LVSVT) originates in the epicardium of the superior left ventricular wall, between the origins of the main coronary arteries, with character...

Roles of Ceramide Glucosyltransferase in Controlling Cerebral Microvascular Endothelial Integrity and Angiogenesis Post-Ischemia/Reperfusion.

Sphingolipids critically regulate microvascular integrity and function, but the role of glycosphingolipids in endothelial survival and angiogenesis remains poorly defined. Herein, we experimentally de...

Comparative outcomes of robot-assisted and open radical nephrectomy with inferior vena cava thrombectomy for renal cell carcinoma: a systematic review and meta-analysis.

For patients with renal cell carcinoma (RCC) complicated by inferior vena cava (IVC) tumor thrombus, radical nephrectomy combined with thrombectomy remains a key surgical option. Open radical nephrect...

Giant cell myocarditis: from immune pathogenesis to contemporary management.

Giant cell myocarditis (GCM) is a rare but devastating inflammatory cardiac disease characterized by rapid hemodynamic deterioration, malignant arrhythmias, and high rates of death or heart transplant...

Histopathological analysis of a retrieved cerebral thrombus revealing occult lung adenocarcinoma: a case report.

BACKGROUND: Cancer-associated stroke (CAS) is a heterogeneous entity in which hypercoagulability represents the most common mechanism, whereas direct tumour embolism is rare and likely under-recognise...

Panax ginseng C.A. Mey. as Multi-Target Regulators of Vascular Homeostasis: Pharmacological Mechanisms and Therapeutic Perspectives.

Cardiovascular and cerebrovascular diseases (CVDs) are closely associated with disturbances in vascular homeostasis, including endothelial dysfunction, abnormal vascular remodeling, inflammation, oxid...

Image Quality as an Important Confounder in Quantitative OCT Angiography: A Review with Quantitative Synthesis.

BACKGROUND: Optical coherence tomography angiography (OCTA) provides quantitative metrics of the retinal microvasculature, most prominently vessel density (VD), that are increasingly used as biomarker...

MitoQ Has Diverse Effects on H(2)O(2)-Induced Oxidative Stress and the NRF2 Signalling Pathway in Aortic Smooth Muscle Cells of Different Origins.

Oxidative stress plays a central role in the development and progression of abdominal aortic aneurysms (AAA), as it severely impairs the function and survival of vascular smooth muscle cells (VSMCs). ...

NaF-PET Imaging for Detection of Early Arterial Microcalcification and Monitoring of Targeted Therapy: A Narrative Review.

Ischemic heart disease is currently diagnosed mainly through cardiac computed tomography (CT) angiography and functional testing, both of which detect only advanced arterial macrocalcification, at a s...

May-Thurner Syndrome secondary to the oral contraceptive pill.

PRESENTATION: A teenaged female patient presented with left leg pain and swelling for two days. The pain radiated to the left iliac fossa and suprapubic region. DIAGNOSIS: May Thurner Syndrome with ex...

Pathogenesis and molecular mechanisms of mutant TIE2-driven venous malformation.

Venous malformation (VM) is the most common subtype of vascular malformation. Due to the chronic nature of this disorder, VM patients face significant morbidity and complications throughout their live...