Antisense oligonucleotide-mediated disruption of mRNA localisation inhibits angiogenesis.

mRNA localisation is a critical posttranscriptional mechanism that confers a spatiotemporal dimension to the control of gene expression. Among diverse outcomes, this process can result in compartmenta...

Surgically managed paediatric external jugular vein pseudoaneurysm.

Aneurysms and pseudoaneurysms predominantly affect the high-pressure arterial system; venous manifestations are exceedingly rare. While the internal jugular vein is the most common cervical site-typic...

Women in healthy transition deep phenotyping cohort study protocol (KiSO-DP): a within-participant multidisciplinary longitudinal cohort study across the menopausal transition.

BACKGROUND: Cardiovascular disease risk accelerates in women after the menopausal transition, coinciding with the cessation of endogenous oestrogen production. The accompanying decline in vascular fun...

Tracing the origins of de novo coronary collateral formation in cardiac repair.

Coronary collateral arteries have been proposed to form de novo through artery reassembly, a process in which arterial endothelial cells (ECs) migrate away from preexisting arteries and reassemble int...

Modality-specific neurovascular coupling via layer-segregated arteriole networks.

The brain's vascular system dynamically regulates energy supply through neurovascular coupling. In this study, we show that in mice, neurovascular coupling is modality-dependent: Distinct sensory inpu...

Targeting ACTG1 alleviates isoproterenol-induced cardiac injury by regulating endothelial-to-mesenchymal transition.

The pathological mechanisms underlying cardiac fibrosis after isoproterenol (ISO)-induced cardiac injury remain poorly understood. Additionally, the biological function of ACTG1 in cardiovascular dise...

Macular perfusion analysis using optical coherence tomography angiography post rhegmatogenous retinal detachment repair: a systematic review and meta-analysis.

BACKGROUND: Evaluating rhegmatogenous retinal detachment (RRD) repair traditionally focuses on anatomical reattachment and visual acuity. Understanding macular perfusion changes post-repair offers a m...

Role of semaphorin 4f in cardiac fibroblasts to regulate matrix production through actin remodeling and YAP/TAZ activation.

Cardiac fibrosis remains a critical determinant of adverse outcomes in heart disease, yet effective anti-fibrotic therapies are lacking. While multiple semaphorin family members participate in cardiov...

APOM-associated inflammation and apoptosis in stroke-exacerbated myocardial infarction: implications for brain-heart interactions.

Brain-heart syndrome (BHS) describes cardiac dysfunction secondary to central nervous system injury, with acute ischemic stroke (AIS) serving as a critical driver that exacerbates myocardial infarctio...

[A semi-supervised MRI image segmentation dual-network model for regions with ambiguous boundaries and heterogeneous regions].

OBJECTIVES: To construct a high-value region-guided dual-network semi-supervised segmentation method (HVASS) under extremely low labeling rates for addressing the challenges of heterogeneity and blurr...

[Effects of exosomes derived from normoxic or hypoxic human umbilical vein endothelial cells on hypoxia-induced cardiomyocyte injury and cardiac fibroblast activation in vitro].

OBJECTIVES: To investigate the effects of exosomes derived from human umbilical venous endothelial cells (HUVECs) cultured in normoxic and hypoxic conditions (N-exo and H-exo, respectively) on hypoxia...

[LCN2 knockout protects endothelial barrier function in mice with sepsis-induced acute lung injury by regulating the NF-κB signaling pathway].

OBJECTIVES: To investigate the protective effect of lipocalin-2 (LCN2) gene knockout against sepsis-induced acute lung injury (ALI) and vascular endothelial dysfunction in mice and the mediating role ...

Beyond Bone Health: Exploring the "Heart-Brain-Bone" Axis Modulated by Lipid-Soluble Nutrients (Omega-3, Vitamin D3, and Vitamin K2).

BACKGROUND: Population aging is driving a convergent rise in three disorders historically managed in isolation: cardiovascular disease, neurocognitive decline, and osteoporotic bone loss. Mechanistic ...

BDNF/TrkB Signaling in Intracardiac Ganglia Modulates Cardiac Parasympathetic Tone.

Brain-derived neurotrophic factor (BDNF) impacts parasympathetic nervous system function by increasing the excitability of cardioinhibitory parasympathetic neurons in the brainstem, ultimately lowerin...

Reduced microvascular coverage links a hypoxia-associated niche to microglial autophagic dysfunction in Parkinson's disease.

Microglial hyperactivation contributes to Parkinson's disease (PD) progression, yet the upstream microenvironmental cues that sustain this state remain incompletely understood. While α-synuclein (α-Sy...

Pirfenidone restores metabolic hormones and cardiac autophagy via p-AMPK in MASH.

BACKGROUND: Obesity promotes chronic inflammation and insulin resistance, disrupting key metabolic hormones (e.g., insulin and leptin) and triggering metabolic dysfunction-associated steatohepatitis (...

Microvascular remodeling and endothelial dysfunction across the post-COVID-19 spectrum: a prospective observational case-control study.

BACKGROUND: Post-viral diseases, including post-COVID-19 syndrome (PCS) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), cause substantial long-term morbidity. Persistent cardiovascula...

Intraluminal morphometric analysis of abdominal aortic branches: spatial landmarks for interventional radiology and colorectal surgery.

PURPOSE: Precise knowledge of the spatial relationships of abdominal aortic branches is essential for safe colorectal surgery and interventional radiologic (IR) procedures. While most studies describe...

Four-year evolution of the retinal microvasculature in an APOE ε4/ε4 cognitively normal individual.

Alzheimer's disease is a neurodegenerative disorder with a prolonged preclinical phase during which pathological changes begin 15-20 years before clinical presentation. We present longitudinal optical...

Endovenous Treatment Of Superficial Chronic Venous Disease In A Strict Ambulatory Setting: A Single-Center Experience.

INTRODUCTION: Minimally invasive endovenous techniques have become central to the treatment of superficial chronic venous disease (CVD) of the lower limbs. Their ability to avoid general or locoregion...