A robotic simulation platform for fluoroscopy-guided catheter navigation in transcatheter tricuspid valve intervention: system development and proof-of-concept applications.
Robot-assisted transcatheter tricuspid valve intervention requires operators to manipulate a flexible catheter through a robotic interface while interpreting two-dimensional fluoroscopic images. Howev...
SARS-CoV-2 disrupts the integrity of a human blood-brain barrier model in the absence of infection.
Neurological symptoms are recognized in patients with COVID-19, and include anosmia, ageusia, cognitive impairments as well as more severe complications including encephalitis and ischemic strokes. Fu...
Cellular Prion Protein as a Novel Regulator of Vascular Plexus Stability During Retinal Angiogenesis.
Angiogenesis is essential not only during embryogenesis but also in adult physiology and disease, relying on vascular endothelial growth factor (VEGF) gradients to guide tip cell sprouting. Cellular p...
Arboviral infections of the central nervous system: Mechanisms of invasion and long-term consequences.
Arboviruses are a diverse group of vector-borne viruses that cause significant global morbidity and mortality. Beyond classical systemic and febrile symptoms, many arboviruses can induce a spectrum of...
A refined subclavian cardiac puncture method for longitudinal blood collection in mice.
Murine blood sampling is essential for pharmacokinetic research and chronic disease modeling. However, conventional techniques such as tail vein or retro-orbital blood collection have low sample volum...
[Numerical simulation of coping strategies for the "bird-beak" phenomenon in thoracic endovascular aortic repair].
This study aims to explore the effects of different surgical strategies on the "bird-beak" phenomenon during thoracic endovascular aortic repair (TEVAR), so as to provide a theoretical basis for clini...
[A study on three-dimensional reconstruction of coronary arteries and numerical simulation of fractional flow reserve based on deep learning].
To address the needs of geometric modeling and hemodynamic analysis in the noninvasive functional assessment of coronary heart disease, this study establishes a deep learning-based integrated framewor...
Neonatal outcome in macrosomia and gestational diabetes mellitus depending on the definition of macrosomia: a retrospective cohort study.
INTRODUCTION: Gestational diabetes increases the risk of neonatal macrosomia, which is associated with maternal and neonatal morbidity. However, the definition of macrosomia is inconsistent and includ...
BIN1 overexpression rescues cardiac but not skeletal muscle defects in a mouse model of caveolinopathy.
Mutations in CAV3, encoding caveolin-3, cause caveolinopathies, rare genetic disorders affecting both skeletal and cardiac muscle. Caveolin-3 contributes to T-tubule formation and excitation-contracti...
Common Versus External Iliac Arterial Anastomosis in Kidney Transplantation: A Bicentric Retrospective Analysis of Vascular Complications and Graft Outcomes.
BACKGROUND Vascular complications remain a significant concern after kidney transplantation. While external iliac (EI) implantation is standard, common iliac (CI) implantation is occasionally performe...
ALKBH3 inhibition normalizes neovessels by reprogramming endothelial fate in diabetic microvasculopathy.
Diabetic microvasculopathy is a serious diabetes complication, with diabetic retinopathy (DR) being a leading cause of blindness worldwide due to immature, leaky neovessels. Antiangiogenic therapies m...
[Electroacupuncture at "Xinshu" (BL15) improves myocardial ischemia by inhibiting the ferroptosis pathway in rats].
OBJECTIVES: To explore the role of the ferroptosis pathway of myocardial cells in electroacupuncture (EA) at "Xinshu" (BL15)-induced improvement of myocardial ischemia (MI) in rats. METHODS: A total o...
Electromechanical activation and recovery wave imaging for pediatric mitral valve disease characterization.
Mitral valve (MV) disease, particularly MV prolapse (MVP) and mitral regurgitation (MR), affects 2 to 5% of the population and poses a substantial arrhythmogenic risk, with 43% of MVP patients develop...
Association of Enlarged Perivascular Spaces and Total Small Vessel Disease Burden With Kidney Function.
BACKGROUND AND OBJECTIVES: Enlarged perivascular spaces (EPVSs) in the basal ganglia (BG-EPVS) are an important marker of cerebral small vessel disease (cSVD), and EPVS in the centrum semiovale (CSO-E...
2-Year Patient-Centered and Clinical Outcomes of Sirolimus- Versus Paclitaxel-Coated Balloon Angioplasty in Femoropopliteal Artery Disease.
BACKGROUND: Drug-coated balloons improve outcomes after femoropopliteal angioplasty, but concerns regarding the long-term safety of paclitaxel-coated devices have prompted interest in alternative anti...
Redo-Transcatheter Aortic Valve Replacement With Self-Expanding Valves: A U.S. Registry Analysis.
BACKGROUND: Redo-transcatheter aortic valve replacement (TAVR) for failed transcatheter heart valves is expected to increase, but data on outcomes with self-expanding valves remain limited. OBJECTIVES...
Outcomes of Supra-Annular vs Intra-Annular Self-Expanding Valves in Valve-In-Valve Transcatheter Aortic Valve Replacement.
BACKGROUND: Self-expanding valves appear to have superior hemodynamics compared with balloon-expandable valves for valve-in-valve transcatheter aortic valve replacement (ViV-TAVR). OBJECTIVES: This st...
A cerebrospinal fluid blood-brain barrier dysfunction score is associated with progression from mild cognitive impairment to Alzheimer's disease.
BACKGROUND: Blood-brain barrier permeability-related alterations are increasingly recognised as an early process in Alzheimer's disease, but their prognostic value and candidate molecular markers rema...
Synthetic versus biological patches for carotid endarterectomy.
RATIONALE: Extracranial carotid artery stenosis is a major cause of stroke. Carotid endarterectomy with patch angioplasty is a widely used surgical technique to reduce the risk of stroke in people wit...
USP10 mitigates Ang II-induced atrial remodeling and atrial fibrillation susceptibility by deubiquitinating NDUFS1.
Atrial fibrillation (AF) contributes to cardiovascular morbidity and mortality. Ubiquitin-specific peptidase 10 (USP10) plays a crucial role in numerous cellular processes; however, its particular rol...