[Research progress in myocardial metabolic reprogramming in atrial fibrillation].
心房颤动（房颤）是临床常见的心律失常，其病理机制涉及电重构与代谢调节网络的复杂相互作用。值得注意的是，房颤可引发显著的心肌代谢重编程，这种代谢稳态失衡不仅加速心房结构重构，更是维持颤动波持续传导的关键病理基础。该文系统阐述了房颤中心肌能量代谢障碍、脂质代谢失调、氨基酸代谢紊乱等核心代谢表型特征，以及线粒体功能障碍与氧化应激级联反应在其中的调控作用，并分别介绍不同类型的心脏细胞在房颤中的代谢重编程，...
[Research progress in the mechanism of coronary artery ectasia].
冠状动脉扩张是一类以冠状动脉管径异常扩张为特征的罕见病，其病因多样，发病机制尚未完全阐明，治疗手段有限，且预后不良。近年来国内外对该疾病的机制研究多聚焦于免疫炎症和细胞外基质降解两方面，但对不同病因所致冠状动脉扩张的发病机制的异同仍不清楚。为了加强对该疾病的认知、更好地指导临床诊疗，该文基于冠状动脉扩张的病因，对其发病机制予以总结和探讨。.
[Research progress in HIPPO signaling pathway in cardiovascular diseases].
心血管疾病（CVD）是全球范围内死亡的主要原因之一。成熟心肌细胞再生能力丧失是制约CVD临床疗效的关键障碍，心肌细胞发生损伤坏死后，心脏难以通过内源性增殖实现组织修复。HIPPO信号通路可调控心肌细胞增殖、肥大与死亡进程，在心肌损伤修复中发挥重要作用，有望改善心肌梗死后心脏泵血功能、减少恶性心律失常、延缓心力衰竭进展。该文综述HIPPO信号通路参与CVD发生发展的调控机制，为靶向干预该信号通路实现...
[Safety and efficacy of Laager left atrial appendage occlusion system in patients with nonvalvular atrial fibrillation: a prospective, multicenter clinical study].
Objective: To investigate the safety and efficacy of the Laager left atrial appendage occlusion system in stroke prevention in patients with atrial fibrillation. Methods: This was a prospective, multi...
The vision to develop a mechanical blood pump to support or replace the failing human heart was originally proposed in the late 1950s by Dr DeBakey. Since then, a portfolio of durable devices has been...
It remains unclear what the safe serum potassium range is in heart failure (HF) and whether it is the same in HF with reduced ejection fraction (HFrEF) and HF with preserved ejection fraction (HFpEF).
Heart failure (HF) remains a major cause of morbidity, mortality and costs for the healthcare systems worldwide, despite advances in diagnostic and therapeutic strategies. The enhancement of preventiv...
Cardiac fibroblast (CF) activation in response to injury or inflammation is a central driver of pathological cardiac fibrosis, contributing to arrhythmias and heart failure. As previously demonstrated...
Haemodynamic control of zonated liver function via instructive vascular Wnt signalling.
The vascular endothelium forms a systemically disseminated organ that translates micromilieu factors into instructive cues, designated as angiocrine signalling. While vascular control of organ functio...
Enhanced mitigation of diabetic myocardial injury in rats via modulating the adiponectin/IRS-1/PI3K/p-AKT/FOXO-1 signaling by combining methotrexate and insulin.
PURPOSE: The present study aimed to explore the impact of combining methotrexate (MTX) and insulin (INS) to mitigate diabetes-associated myocardial injury and investigate the potential underlying mech...
Evaluation of endothelial dysfunction in women with prolactinoma.
AIM: Prolactinoma has been associated with impaired glucose metabolism and adverse cardiometabolic outcomes. This study aimed to evaluate the metabolic effects of hyperprolactinemia and its impact on ...
Evaluating the endothelial glycocalyx from bench to bedside: a translational framework for microvascular assessment.
The endothelial glycocalyx (eGCX) plays a crucial role in mechanotransduction, maintaining vascular barrier integrity, and facilitating leukocyte-endothelial crosstalk. However, accurately quantifying...
Subjective sleep disturbances are associated with reduced MRI-derived perivascular-space diffusivity in multiple sclerosis.
BACKGROUND AND OBJECTIVE: Sleep modulates brain-fluid transport and glymphatic clearance. In multiple sclerosis (MS), lower diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) in...
Effect of COVID-19 on Retinal and Choroidal Microvasculature in the Pediatric Population: A Literature Review.
Backgroundand Objectives: Retinal microcirculation may serve as a surrogate marker of systemic vascular status and can be non-invasively assessed using optical coherence tomography angiography (OCTA)....
Spatial Metabolomics Reveals the Common and Compound-Specific Pharmacological Mechanisms of Two Alkaloids Against Infarcted Myocardium.
Acute myocardial infarction (AMI) is a leading cause of death worldwide, characterised by systemic inflammation and metabolic disorders. Tetrahydropalmatine (THP) and berberine (BBR) are major alkaloi...
Divergent Immune and Endothelial Responses to Insulin Resistance in Women with Polycystic Ovary Syndrome.
Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine-metabolic disorder frequently associated with insulin resistance (IR) and increased cardiovascular risk. Soluble CD40 ligand (sCD40L) and ...
An Optimized Protocol for Guidewire-Induced Aortic Valve Stenosis Model in Mice.
Aortic valve stenosis (AVS) is a major cardiovascular disease with increasing prevalence in aging populations, yet the scarcity of diseased valve tissue severely limits mechanistic studies and therape...
Assessment of Left Ventricular Myocardial Fibrosis and Edema in Atrial Fibrillation Using Cardiovascular Magnetic Resonance.
Progressive population aging has driven a steady rise in the incidence of atrial fibrillation (AF), making the management of its long-term prognosis an increasingly important clinical concern. In addi...
Generation of Fibrin-Based Three-Dimensional Engineered Vascular Tissues from Human Aortic Smooth Muscle Cells for Proteomic Analysis.
Vascular smooth muscle cells (SMCs) reside within the medial layer of blood vessels, where they interact with an extracellular matrix (ECM) composed of collagen, elastin, and proteoglycans to maintain...
Superb microvascular imaging within intestinal ultrasonography predicts endoscopic ulcers in the terminal ileum of patients with Crohn's disease.
This retrospective study aimed to investigate whether superb microvascular imaging (SMI) can predict endoscopic findings in the terminal ileum of patients with Crohn's disease (CD). Patients with CD w...