Developmental Toxicity and Mechanistic Insights into the Novel Fungicide Fluindapyr in Zebrafish Embryos.

Succinate dehydrogenase inhibitor (SDHI) fungicides pose potential risks to nontarget aquatic organisms. Fluindapyr, a newly registered SDHI fungicide, is likely to enter aquatic environments, yet its...

In Vivo Tracking Deciphers the Traversal of Ebola Virus across the Blood-Testis Barrier.

Ebola virus (EBOV) can persist in semen to mediate sexual transmission and drive epidemic resurgence. However, the mechanism by which EBOV breaches the blood-testis barrier (BTB) to invade the male re...

Angiographic Demonstration of a Transverse Sinus Fenestration Coexisting with a Kobayashi Type 4B Torcular Variant: Case Report.

This report describes an exceptionally rare case of an incidental angiographic fenestration of a dominant right transverse sinus (TS) associated with a Kobayashi type 4B torcular variant in a 54-year-...

Engineering ApoE3-Targeted NIR-Responsive Liposomes for Multimodal Inhibition of Amyloid-β Aggregation and Acetylcholinesterase Activity.

Alzheimer's disease (AD) is characterized by progressive neurodegeneration and cognitive decline, largely driven by amyloid-β (Aβ) aggregation and dysregulated acetylcholinesterase (AChE) activity. Wh...

From chemical oscillators to biological synchrony: a programmable reaction-diffusion model for studying signal coordination in cardiomyocyte networks.

The self-organization of asynchronous rhythms into synchronized beating in in vitro cardiomyocyte networks is a fundamental problem in systems biology research. Inspired by the dynamics of chemical os...

Empagliflozin Improves Post-Infarct Heart Failure Through Fibroblast Growth Factor-21 and Ketone Body Oxidation Pathway.

Background: Sodium-glucose cotransporter-2 (SGLT2) inhibitors improve outcomes in heart failure, but the mechanisms remain incompletely understood. Metabolic remodeling has been proposed as a key medi...

En kvinne i 60-årene med rødt øye, tåkesyn og allmennsymptomer.

BACKGROUND: Panuveitis is a severe intraocular inflammatory condition that can have infectious, autoimmune, or neoplastic aetiologies. In rare cases, it may represent an early manifestation of systemi...

Precision Ligation of the Left Anterior Descending Coronary Artery Using Anatomical Landmarks in a Murine Myocardial Infarction Model.

Permanent ligation of the left anterior descending (LAD) coronary artery is the most widely used approach for establishing mouse models of myocardial infarction (MI) in preclinical cardiovascular rese...

Auricular Acupressure for Managing Nausea-Vomiting, Pain and Fatigue After Liver Arterial Chemoembolization and Hepatic Arterial Infusion Chemotherapy.

Patients undergoing transarterial chemoembolization or hepatic arterial infusion chemotherapy frequently experience nausea, vomiting, pain, fatigue, sleep disturbance, and appetite loss during hospita...

Arterial versus Venous Watershed Localization for Nonpalpable Pulmonary Nodules: A Retrospective Study.

Accurate localization of nonpalpable pulmonary nodules is critical for successful surgical resection. This study aimed to evaluate the feasibility and safety of the watershed localization method (WALM...

Ultrasound-Controlled Blood-Brain Barrier (BBB) Opening in a BBB-Glioblastoma Microfluidic Chip for Drug Delivery Studies.

The blood-brain barrier (BBB) is a major obstacle to treating glioblastoma (GBM) by restricting the entry of most therapeutic molecules into the brain. Interspecies differences in BBB structure and fu...

Identification of Pro-Atherogenic Microenvironment-Associated Molecular Signatures in Response to Key Effective PM2.5 Constituents Using a Blood-Brain Barrier-Immune Microenvironment Platform.

Fine particulate matter (PM2.5) has been associated with adverse central nervous system (CNS) outcomes, yet it remains unclear how PM2.5 constituents penetrate the blood-brain barrier (BBB) and which ...

Qualitative and Quantitative Prediction of Blood-Brain Barrier Permeability of Chemicals via an SE(3)-Transformer-Based Model with LLM-Assisted Explanation.

The blood-brain barrier (BBB) regulates the entry of chemicals into the central nervous system, and contaminants with high permeability can accumulate in the brain, posing neurotoxicity risks. Given t...

Clinical Relevance of Serum Inducible and Endothelial Nitric Oxide Synthase Ratio for Pulmonary Hypertension in Acute Exacerbated Chronic Obstructive Pulmonary Disease.

BACKGROUND: Pulmonary hypertension (PH) is a common complication of acute exacerbated chronic obstructive pulmonary disease (AECOPD) and is associated with poor prognosis. Nitric oxide synthase (NOS) ...

Inhibition of RBM25 preserves cardiac mitochondrial homeostasis and attenuates ischemic heart failure.

Heart failure (HF) after myocardial infarction (MI) is a serious complication that endangers the health of the patient. Mitochondrial dysfunction is an important mechanism in the development of ischem...

GLSP ameliorates monocrotaline-induced pulmonary arterial hypertension through inhibition of the PI3K/AKT and MAPK signaling pathways.

Pulmonary arterial hypertension (PAH) is characterized by pulmonary vascular remodeling and right heart dysfunction, driven largely by excessive proliferation of pulmonary arterial smooth muscle cells...

Potassium-Selective Nanoelectrode Arrays for Single-Cell Profiling of Human iPSC-Derived Cardiomyocytes.

Potassium ion (K+) dynamics are central to cardiac electrophysiology, with early disruptions in K+ flux often preceding arrhythmia and contractile dysfunction. However, current sensing technologies, s...

Topographic anatomy of suprascapular artery branches in the supraspinatus fossa: surgical implications for rotator cuff and muscle advancement.

PURPOSE: The suprascapular artery (SSA) is the main vascular supply to the rotator cuff musculature, but its detailed branching pattern in the supraspinatus fossa and clinical relevance for surgery an...

The evolving role of computed tomography angiography in superficial circumflex iliac artery perforator flap mapping from anatomy to surgery: a systematic review.

PURPOSE: The reliable application of the superficial circumflex iliac artery perforator (SCIP) flaps is frequently hindered by significant anatomical variability in its vascular supply. Preoperative m...

Cellular crosstalk between endothelial and vascular smooth muscle cells via the BACH1/COL3A1 axis promotes vascular calcification in chronic kidney disease.

BACKGROUND: High phosphate levels lead to significant pathological changes in vascular smooth muscle cells (VSMCs) and endothelial cells, driving vascular disease in chronic kidney disease (CKD). Endo...