GPR132 antagonists alleviate atherosclerosis by suppressing M1 polarization and subsequent VSMCs proliferation and migration as revealed by transcriptomic profiling.

BACKGROUND: Atherosclerosis (AS) is a chronic inflammatory disorder with substantial global prevalence, wherein macrophage polarization and vascular smooth muscle cells (VSMCs) phenotypic switching ar...

Overcoming the blood-brain barrier using central nervous system-accessing lipid nanoparticles for enhanced mRNA therapeutics.

Messenger RNA (mRNA) therapeutics hold potential for central nervous system (CNS) disease treatment. However, the blood-brain barrier (BBB) presents a major obstacle, preventing efficient delivery of ...

AAV-NRF2 protects retinal and choroidal vasculature in a GDF15-dependent manner in an oxidative damage model of AMD.

Oxidative stress is proposed to be a driver of age-related diseases. Age-related macular degeneration (AMD) is one such disease, where the retinal pigment epithelium (RPE) is affected early in the dis...

Induced Pluripotent Stem Cell-Based Platforms for Cardiac-Related Pain Research: Molecular Mechanisms, Experimental Models, and Therapeutic Applications.

Cardiac-related pain, including angina pectoris and pain accompanying myocardial infarction, remains clinically important, and existing treatments are inadequate for some patients. Animal and primary-...

Cerebral Intramural Cells: A Missing Cellular Link Between Vascular Aging and Alzheimer's Disease.

The pathological deposition of amyloid-β (Aβ) in the walls of cerebral blood vessels as cerebral amyloid angiopathy (CAA) is a key feature of Alzheimer's disease (AD) and is linked to impaired clearan...

FHL3 Regulates Vascular Smooth Muscle Cell Phenotypic Switching Through the MRTFB-SRF Signaling Axis.

Genome-wide association studies have uncovered many coronary artery disease (CAD) loci, but mechanisms linking risk variants to vascular biology remain unclear. We screen candidate causal CAD genes fo...

Retrospective Evaluation of an AI-Based Computer-Aided Detection Algorithm for Lung Cancer Detection on Cardiac CT: A Multicenter Study.

BACKGROUND: To investigate the effectiveness of an artificial intelligence (AI)-based computer-aided detection (CAD) system in identifying incidental lung cancer on cardiac computed tomography (CT) sc...

Characteristics and outcomes of spontaneous coronary artery dissection of the left anterior descending artery.

BACKGROUND: Spontaneous coronary artery dissection (SCAD) is an underrecognised cause of acute coronary syndrome (ACS). The left anterior descending artery (LAD) is most frequently affected, but the c...

Outcomes of patients with large anatomies undergoing transcatheter tricuspid valve replacement with the LuX-Valve Plus system.

BACKGROUND: Transcatheter tricuspid valve replacement (TTVR) is increasingly performed to treat patients with severe or greater symptomatic tricuspid regurgitation (TR) at high risk for surgery. Howev...

CKLF1 Serves as a Pivotal Mediator of Blood-Brain Barrier Disruption and Neuroinflammation via PI3K/AKT/mTOR Signaling in Ischemic Stroke.

Ischemic stroke (IS) is accompanied by blood-brain barrier (BBB) disruption and neuroinflammatory activation, but the upstream regulatory mechanisms remain incompletely defined. Here, integrated singl...

Derivation of human post-mitotic cardiomyocytes from tetraploid iPSCs.

Human induced pluripotent stem cell (iPSC)-derived cardiomyocytes (iPS-CMs) have great potential in regenerative medicine. However, iPS-CMs are immature and resemble fetal cardiomyocytes, restricting ...

Subclinical ocular microvascular involvement in primary antiphospholipid syndrome and antiphospholipid antibody carriers.

OBJECTIVES: Investigate the role of antiphospholipid antibodies (aPL) in determining subclinical microvascular alterations in patients with primary antiphospholipid syndrome (PAPS) and antiphospholipi...

Transferrin-Conjugated Polymeric Nanoparticles via Polymerization-Induced Self-Assembly for Enhanced BBB Transport and Glioblastoma Therapy.

Transferrin-coated nanoparticles show promise in delivering chemotherapeutic drugs across biological barriers for treating glioblastoma multiforme (GBM). Employing a synthetic approach integrating adv...

Real-life data is very useful for gaining a better understanding of care in practice and identifying areas for improvement. This study aimed to assess changes in the clinical characteristics, care and...

Indoxyl Sulfate Promotes Vascular Calcification in Association with Oxidative Stress and Activation of ERK and Wnt/β-Catenin Signaling Pathways.

Vascular calcification (VC) is a major complication of chronic kidney disease (CKD) that is strongly associated with cardiovascular mortality. While indoxyl sulfate (IS), a protein-bound uremic toxin,...

Severe Tricuspid Regurgitation: Traumatic Papillary Muscle Rupture Mimicking Infective Endocarditis-A Case Report.

BACKGROUND Differentiating traumatic tricuspid regurgitation (TR) from infective endocarditis (IE) is clinically crucial in patients presenting with abnormal tricuspid valve findings after blunt chest...

[Research progress and applications of biologically derived materials in scleral reconstruction].

OBJECTIVE: To review the research progress and clinical applications of biologically derived materials in scleral reconstruction. METHODS: A comprehensive review of recent domestic and international l...

An(other) interview with Rashmi Priya.

Rashmi Priya is a Group Leader at The Francis Crick Institute, UK. Rashmi's lab uses advanced microscopic, genetics and biophysical approaches to understand the underlying molecular and cellular mecha...

Neuro-images: "string of beads" at vertebral artery origin: 3-year angiographic follow-up after stenting for fibromuscular dysplasia.

Fibromuscular dysplasia (FMD) rarely involves the vertebral artery origin (V1 segment), a site far more commonly affected by atherosclerosis. We report an 81-year-old woman with recurrent, medically r...

PKA-Mediated Proteasome Activation Protects Against Cardiac Remodeling and Heart Failure During Systolic Overload.

Heart failure (HF) resulting from chronic systolic overload is associated with increased burden on proteostasis and impaired proteasome function. Phosphorylation of proteasome subunit RPN6/PSMD11 at S...