Combined prediction of anthracycline-induced cardiotoxicity in patients with breast cancer using neutrophil-to-lymphocyte ratio and left atrial reservoir strain: A prospective observational study.

ObjectiveAnthracycline-related cardiotoxicity may involve systemic inflammatory responses, and the neutrophil-to-lymphocyte ratio may change during chemotherapy as a marker for inflammatory and immune...

Evaluating Partial Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) for Battlefield Trauma: A Comparative Analysis of Commercially Available Catheters.

INTRODUCTION: Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) is a minimally invasive method to control noncompressible torso hemorrhage, now integral to military damage control resu...

Heart Failure Outcome Prediction Using Artificial Intelligence-enabled Coronary Artery Calcium CT Chamber Volumetry Compared to American Heart Association PREVENT and the Agatston Score for Heart Failure Risk Stratification.

Purpose To evaluate whether artificial intelligence (AI)-derived chamber volumetry from coronary artery calcium (CAC) CT improves heart failure (HF) risk prediction. Materials and Methods This retrosp...

Mechanisms, Biomarkers and Therapeutic Implications of Neuroinflammation in Alzheimer's Disease.

Alzheimer's disease (AD) represents the most prevalent neurodegenerative disorder worldwide, affecting millions of individuals and imposing substantial socioeconomic burdens. While traditional researc...

The Association between Hypoperfused Myocardium and Systolic Function in Patients With AMI Undergoing Complete Revascularization.

BACKGROUND: Timely restoring coronary blood flow reduces mortality in acute myocardial infarction (AMI), while epicardial flow restoration is non-parallel to myocardial reperfusion. This prospective s...

In-Vitro Evaluation of HIV/SARS-CoV-2 Co-Infection Mediated Proteomic Changes in Astrocytes and Pericytes Reveals Altered Signaling Pathways Associated With Neurodegenerative Disorders.

Coronavirus disease 2019 (COVID-19) survivors frequently experience a wide range of symptoms known as post-acute sequelae of SARS-CoV-2 (PASC) or long COVID. Importantly, complications arising from mi...

ADAMTS4 mediates LPS-induced cardiac injury and myocardial fibrosis through proteolytic cleavage of TSP1.

Septic cardiomyopathy is characterized by acute cardiac dysfunction, while sustained inflammatory and extracellular matrix remodeling may contribute to subsequent myocardial fibrosis and impaired card...

Impact of Leaflet Thickness on Polymeric Valve Scaffold Function and Remodeling: Assessment in a 1- and 3-Month Ovine Stented Pulmonary Valve Replacement Model.

Approaches to the structural design of tissue engineered heart valves (TEHVs) have varied broadly, ranging from material choice to microstructural and macro-scale functional characteristics. Not only ...

Combined Left Ventricular and Left Atrial Strain Assessment for Long-Term Risk Stratification in Heart Failure With Reduced Ejection Fraction.

PURPOSE: Left ventricular (LV) global longitudinal strain (GLS) and left atrial reservoir strain (LASr) are established predictors of adverse outcomes in heart failure with reduced ejection fraction (...

Ejection Fraction in the Fast Lane.

Ventricular performance is typically evaluated on the basis of primary measurements such as pressure, volume and flow. Representative recordings obtained from a healthy, chronically instrumented consc...

Microbiota-Neuroinflammation Crosstalk in Primary Brain Tumors: Focus on Glioblastoma.

PURPOSE: Glioblastoma (GBM) is the most aggressive primary brain tumor in adults and remains difficult to treat because of diffuse invasion, immunosuppression, metabolic adaptability, and therapy resi...

Letter to the editor re: Sathya A, Nguyen TN, Klein P, et al. Endovascular vs surgical treatment of sigmoid sinus diverticulum causing pulsatile tinnitus: A systematic review. Interv Neuroradiol. 2024 Mar 22:15910199241231325.

Letter to the Editor re: Sathya A, Nguyen TN, Klein P, et al. Endovascular vs surgical treatment of sigmoid sinus diverticulum causing pulsatile tinnitus: A systematic review. Interv Neuroradiol. 2024...

Loss of BCAP31 or POLR1E Accelerates Aging in C. elegans and is Linked to Senescence in Vascular Endothelium.

Aging involves the progressive decline of cellular function, yet the key molecular regulators that determine aging require further identification. Building on our previous finding that the intracellul...

TAK1 operates at the primary cilium in non-canonical TGFB/BMP signaling to control heart development.

Pathogenic variants in the genes encoding the non-canonical TGFB signaling components TAK1 (MAP3K7), TAB2 and PKA-Cα (PRKACA) cause rare multisystem disorders, which may include congenital heart disea...

Comparison of Second-line Hepatic Arterial Infusion Chemotherapy and Tyrosine Kinase Inhibitors in Advanced Hepatocellular Carcinoma.

Background With the advent of immune checkpoint inhibitor-based combination therapy, treatment sequencing for advanced hepatocellular carcinoma (HCC) has become increasingly complex. The Barcelona Cli...

Associations of Popliteal Artery Wall Morphology at MRI and Knee Osteoarthritis in the Osteoarthritis Initiative.

Background Vascular factors have been associated with osteoarthritis (OA), but the association between popliteal artery wall morphology and symptomatic and radiographic knee OA outcomes over time rema...

The Reliability and Validity of Manual Palpation to Assess Lower Limb Arterial Occlusion Pressure in Older Adults, for Application in Blood Flow Restriction Exercise.

(A) Investigate test-retest reliability of posterior tibial pulse palpation to determine arterial occlusion pressure (AOP) and examine validity against hand-held Doppler ultrasound. (B) Investigate th...

β3-AR/β-arrestin2 Interaction Triggers Cardiac Fibrosis Through JNK/c-Jun Pathway in Cardiac Fibroblasts.

Myocardial fibrosis (MF) is a critical pathological substrate of heart failure (HF), and β3-adrenergic receptor (β3-AR) has been implicated in cardiac remodelling with controversial roles. This study ...

Inhibiting HIF-1α-Induced miR-663b Improves Pulmonary Arterial Hypertension by Reducing Dysfunctions of PASMCs Through Repressing Sirt1-ZBP1-Mediated PANoptosis.

Pulmonary arterial hypertension (PAH) is a progressive disease characterised by vascular remodelling. Inflammatory responses and oxidative stress have been shown to contribute to its progression. This...

OCT-Defined Plaque Morphology and Clinical Outcomes After Percutaneous Coronary Intervention: An ILUMIEN IV Substudy.

BACKGROUND: Optical coherence tomography (OCT) can differentiate plaque morphology (fibrous, lipidic, and calcified) within atherosclerotic lesions. The prognostic impact of predominant OCT plaque typ...