The MagMa Study: Quantum Magnetocardiography in Cardiomyopathy.

BACKGROUND: Rapid diagnostic screening is an unmet need in patients with suspected cardiomyopathy (CM). The authors recently demonstrated in a retrospective study that magnetocardiography (MCG) may be...

Protective Effect of Isoflurane on Hypoxia/Reoxygenation-Induced Myocardial Injury via miR-548a-5p Regulation of PTEN.

Ischemia-reperfusion (I/R) injury induces cardiomyocyte apoptosis, oxidative stress and elevated myocardial injury markers. This study aimed to investigate whether the microRNA-548a-5p (miR-548a-5p)/p...

The Effect of Transpulmonary Pressure-Guided Positive End-Expiratory Pressure Titration on Pulmonary Arterial Compliance in Acute Respiratory Distress Syndrome Patients: A Single-Center, Randomized Controlled Pilot Pathophysiological Study.

OBJECTIVES: To compare the function of positive end-expiratory pressure (PEEP) titration guided by transpulmonary pressure (Ptp) with traditional lung-protective ventilation to optimize pulmonary arte...

Evaluation of AI-derived LAD artery dose metrics for survival stratification in stage III NSCLC: A secondary analysis of RTOG 0617 trial.

BACKGROUND: While the radiation dose to left anterior descending (LAD) artery is associated with overall survival (OS) in NSCLC patients, manual segmentation is labor-intensive. Several auto-segmentat...

Chronic Smoking Impairs Glymphatic Transport and Cognitive Function in Adolescent Mice Through Cardiac, Vascular, and Perivascular Aquaporin-4 Mechanisms.

AIMS: Smoking significantly impairs cognitive function and is a major risk factor for dementia, particularly when initiated during adolescence, a critical period for brain development. The glymphatic ...

Glymphatic Dysfunction in Children With Type 2 and 3 Spinal Muscular Atrophy.

BACKGROUND: Spinal muscular atrophy (SMA) not only causes lower motor neuron degeneration but also affects brain development. Given the role of the glymphatic system in maintaining brain homeostasis d...

Imaging Biomarkers of the Glymphatic System in the Developing Brain.

The glymphatic system is increasingly recognized as a brain-wide pathway that mediates cerebrospinal fluid-interstitial fluid exchange and metabolic waste clearance. However, unlike in adults, its dev...

Subregion-based maximum similarity search registration method for transverse chromatic aberration correction in ultra-widefield scanning laser ophthalmoscopy images.

SIGNIFICANCE: Ultra-widefield scanning laser ophthalmoscopy (UWF SLO), a confocal scanning-based ophthalmic imaging modality widely used in clinical and research ophthalmology, offers an ultra-wide fi...

Cardiac vagal activity during in-vivo threat exposure is associated with within-session inhibition of fear and avoidance.

Laboratory research suggests that the attenuation of defensive responses during threat exposure relies on the inhibition of subcortical defense circuits orchestrated by the prefrontal cortex. This pro...

Routine Capillary Hemoglobin Testing in United Kingdom Commercial Pilot Applicants.

INTRODUCTION: United Kingdom regulations mandate hemoglobin (Hb) testing at each commercial (Class 1) pilot medical examination. The utility of point-of-care finger-prick capillary Hb in determining a...

DIRECT-SIMMONS/DIRECT-TRACE technique for transradial carotid artery stenting using a novel composite-tip guide catheter: a multicenter retrospective study.

To evaluate the efficacy and safety of a novel DIRECT-SIMMONS/DIRECT-TRACE technique utilizing a composite-tip guiding catheter for transradial carotid artery stenting, addressing the limitations of c...

Functional definition of endothelial progenitors by PROCR and PDGFRA co-expression.

The functional and molecular definition of progenitors giving rise to blood vessel endothelium in vivo remains disputed. Upon investigating the overlap of seemingly divergent reports currently definin...

Cardiovascular safety of psilocybin in psychiatric practice: a narrative review.

PURPOSE: Psilocybin-assisted interventions are moving from efficacy trials toward psychiatric implementation. Cardiovascular interpretation is central to this transition because trial participants are...

Cross-species functional transcriptomic analysis distinguishes conserved aging-niche remodeling from inflammatory fibroblast heterogeneity in cardiac aging and heart failure.

Cardiac aging is accompanied by inflammatory and extracellular-matrix remodeling, but the extent to which aging-associated fibroblast programs are reproducibly altered in human heart failure remains u...

Impact of Left and Right Bundle Branch Block on Left Ventricular Systolic Function and Myocardial Mechanics Assessed by Speckle-Tracking Echocardiography and Cardiac Magnetic Resonance Feature Tracking: A Systematic Review and Meta-Analysis.

BACKGROUND: Bundle branch conduction abnormalities are associated with ventricular dyssynchrony, impaired myocardial mechanics, and progressive systolic dysfunction. Advanced deformation imaging techn...

The Evolving Landscape of Pulmonary Hypertension Treatment: From Vasodilation to Disease Modification.

Pulmonary hypertension (PH) is a complex disorder associated with significant morbidity and mortality. PH is characterized by an elevated pulmonary vascular load, leading to right ventricular dysfunct...

Hsa_circ_0044097 Serves as a Promising Biomarker of Atherosclerosis and Its Effects on Vascular Smooth Cell Proliferation and Migration.

Atherosclerosis (AS) is closely related to the pathogenesis and abnormal proliferation and migration of vascular smooth muscle cells (VSMCs). To explore the value of hsa_circ_0044097 in the clinical m...

Apigenin, Selenium, and Combinations Are Effective in Preventing 5-Fluorouracil Induced Cardiovascular Damage.

Although chemotherapy is still a widely used primary treatment modality for many cancers, it is an accepted fact that it causes many undesirable side effects and toxicity. Until a new, side-effect-fre...

Automated Echocardiographic Assessment of Left Atrial Remodeling in Atrial Fibrillation Using Dynamic HeartModel and AutoStrain LA.

PURPOSE: To compare left atrial (LA) size, emptying function, and strain among non-atrial fibrillation (AF) controls, patients with paroxysmal AF (PAF), and patients with persistent AF (PeAF) using au...

Effects of a Fasting-mimicking Diet on MRI-assessed Cardiac Structure and Function in Participants with Type 2 Diabetes.

Purpose To evaluate the effects of a monthly 5-day fasting-mimicking diet (FMD) for 1 year on left ventricular (LV) geometry and function in individuals with type 2 diabetes (T2D). Materials and Metho...