Pre-Transplant Left Atrial Volume Index and One-Year Morbidity After Kidney Transplantation.
OBJECTIVES: Pre-transplant echocardiography is routinely performed in kidney transplant candidates, although it remains unclear which parameters are associated with the broad spectrum of post-transpla...
Prognostic Value of Prolapse Width for Mid-Term Degenerative Mitral Regurgitation Stability After Transcatheter Edge-to-Edge Repair.
BACKGROUND: Long-term durability of degenerative mitral regurgitation (DMR) reduction after transcatheter edge-to-edge repair (TEER) remains limited, and reliable anatomical predictors are still lacki...
Purtscher-like retinopathy as a presenting ocular manifestation of biopsy-proven giant cell arteritis: A case report.
Purtscher-like retinopathy is a rare retinal microangiopathy characterised by sudden visual loss, cotton wool spots, retinal whitening and variable retinal haemorrhage in the absence of trauma. Giant ...
Impact of bicarbonate on ionized calcium and cardiac function in albumin-free Langendorff perfusion in hearts of male rats.
The adult Langendorff methodology lacks standardization, with inconsistencies in the pH and calcium concentrations of Krebs-Henseleit (K-H) solution. The aim of this study was to clarify these inconsi...
Polarized Light Microscopy for Quantitative Assessment of Sarcomere-Scale Structural Order in Cardiac Tissue.
Polarization-resolved imaging provides a powerful, label-free means of visualizing anisotropic structural order in biological tissue, yet its quantitative exploitation remains limited in routine micro...
From protection to predisposition: A narrative review of sex-specific vascular responses to acute stressors across the lifespan.
Cardiovascular disease (CVD) remains a leading cause of morbidity and mortality, with females exhibiting relative biological protection against CVD compared to males through hormonal and nonhormonal m...
Beyond Left Ventricular and Left Atrial Strain: The Need for Comprehensive Four-Chamber Mechanical Assessment during the Preclinical Phase of Cardiovascular Disease.
The combined assessment of left ventricular global longitudinal strain and left atrial reservoir strain has recently demonstrated significant incremental prognostic value in patients with heart failur...
Agreement Between Standard and Right Ventricular-Focused Apical Four-Chamber Views for Right Ventricular Longitudinal Functional Indices: A Within-Participant Agreement Study.
PURPOSE: To determine whether right ventricular (RV) longitudinal functional indices measured from standard and RV-focused apical four-chamber (A4C) views are interchangeable at the individual level. ...
Sevoflurane Alleviates Myocardial Ischemia-Reperfusion Injury via the HMGB1/ACSL4 Pathway to Suppress Ferroptosis.
Sevoflurane (sevo) exhibits cardioprotective effects against myocardial ischemia/reperfusion injury (MIRI); however, its precise molecular mechanism of action remains elusive and warrants further in-d...
Unveiling the Th17/Treg Imbalance: a New Lens on Macular Perfusion in Thyroid-Associated Ophthalmopathy.
BACKGROUND: The aim of this study was to investigate the association between Th17/Treg imbalance and macular blood flow abnormalities in patients with thyroid-associated ophthalmopathy (TAO). METHODS:...
Early Hemolysis, Myolysis and Renal Stress Following Pentaspline Pulsed Field Versus Radiofrequency Ablation of Atrial Fibrillation.
BACKGROUND: Pulsed field ablation (PFA) is an effective alternative to radiofrequency ablation (RFA) for pulmonary vein isolation (PVI) in atrial fibrillation (AF), offering procedural advantages and ...
Supplemental oxygen induced cardiovascular pathophysiology in an end-of-life care model in mice.
Supplemental oxygen in critical care patients is associated with increased mortality. We previously reported hyperoxia-induces cardiac pathophysiology influenced by age, metabolic status, sex, and dur...
Contrast enhanced ultrasound and laser doppler flowmetry capture distinct aspects of tissue microvascular perfusion in nonhuman primates.
Microvascular perfusion in skeletal muscle (SkM) and subcutaneous adipose tissue (AT) is critical for insulin-mediated glucose uptake and is impaired in type 2 diabetes (T2D). Quantifying perfusion us...
Biofidelic Simulations of the Ross Procedure: Arterial Growth and Remodeling in an Anatomical Context.
The Ross procedure represents a promising alternative to conventional valve replacement techniques in young patients with aortic valve disease. Unlike mechanical or bioprosthetic substitutes, the pulm...
Role of α-SMA, NOX4, Fibronectin, and HIF-1α in Pulmonary Microvascular Remodeling in COPD Patients Without Pulmonary Arterial Hypertension.
BACKGROUND: Pulmonary arterial hypertension (PAH) is a severe chronic obstructive pulmonary disease (COPD) complication, with vascular remodeling occurring early in disease progression. Oxidative stre...
Beyond Venous Inflammation: Vessel Wall Imaging of Intracranial Arteries in Neuro-Behçet's Syndrome.
BACKGROUND: Neuro-Behçet syndrome (NBS) is a heterogeneous inflammatory disorder in which venous involvement is well recognized, while intracranial arterial pathology remains insufficiently characteri...
DASH Diet, Dietary Nitrate, and Nitric Oxide Bioavailability: Implications for Endothelial Dysfunction and Hypertension in Older Adults.
Hypertension in the elderly is closely associated with vascular aging, characterized by endothelial dysfunction (ED) and a progressive decline in nitric oxide (NO) bioavailability. Age-related dysfunc...
Targeting of Pentraxin 3 Alleviated Cardiac Hypertrophy in Mice Induced by Angiotensin II.
Pentraxin 3 (PTX3) responds rapidly to inflammatory signals. This study investigated the functional involvement of PTX3 in angiotensin II (Ang II)-mediated cardiac hypertrophy pathogenesis, with parti...
Clinical Characteristics, Treatment Response, and Prognosis Between Saddle and Non-Saddle Pulmonary Embolism in Intermediate- to High-Risk Acute Pulmonary Embolism.
OBJECTIVE: To investigate the clinical characteristics of patients with saddle pulmonary embolism (SPE) among those with intermediate- to high-risk acute pulmonary embolism (APE). STUDY DESIGN: A comp...
The Therapeutic Potential of H(2)S-Releasing Platforms in Cardiovascular Applications.
Once known as a toxic gas, hydrogen sulfide (H2S) is now making its way into many therapeutic applications. Similar to its other fellow endogenous gasotransmitters, nitric oxide and carbon monoxide, H...