Case series: The role of retinal ischemia in the pathogenesis and clinical manifestation of diabetic retinopathy.
PURPOSE: To highlight retinal ischemia as an important component of diabetic retinopathy (DR) pathogenesis, a significant prognostic factor, and a driver of various DR complications, including neovasc...
Evaluation of motion correction on myocardial [(1) (8)F]F-AraG PET uptake using data-driven respiratory gating.
BACKGROUND: [1 8F]F-AraG (radio-fluorinated 9-β-D-arabinofuranosylguanine) is a PET radiotracer for imaging T-cell activation with emerging applications in myocardial imaging. Cardiac PET is particula...
Inferior Vena Cava Ultrasound Does Not Reliably Estimate Systemic Venous Pressure in Adults With a Fontan Circulation.
PURPOSE: Current ASE/EACVI echocardiography guidelines recommend estimating central venous pressure from inferior vena cava (IVC) diameter and collapsibility in biventricular circulations. Because alt...
Left Ventricular Mechanics and Myocardial Work in Competitive Sprinters.
BACKGROUND: Sprint exercise is characterized by repeated short-duration high-intensity anaerobic activity associated with distinct hemodynamic and autonomic adaptations. However, the effects of long-t...
Left Atrial Coupling Indexes as New Mortality Predictors in Chronic Chagas Disease.
PURPOSE: This study aimed to evaluate the all-cause mortality predictive value of left atrioventricular coupling indexes in patients with chronic Chagas disease (CD). METHODS: This single-center retro...
The Cavβ4 subunit of Cav1.2 channels antagonizes isoproterenol-induced hypertrophy in rat cardiac muscle cells by down-regulating miR-183-5p.
The Cavβ4 subunit of voltage-gated Cav1.2 channels regulates gene expression in neurons and cardiac cells. It increases the expression of interferon-β-related genes in H9c2 cardiomyocytes derived from...
Fetal Superior Mesenteric Artery Peak Systolic Velocity as a Marker of Prenatal Bowel Inflammation in Gastroschisis: A Case-Control Study.
OBJECTIVE: This study aimed to evaluate whether peak systolic velocity (PSV) in the fetal extra-abdominal superior mesenteric artery (SMA) is a useful prenatal marker of bowel inflammation in gastrosc...
Impact of the 2025 ASE Updated Recommendations on the Diagnosis of Left Ventricular Diastolic Dysfunction in Asymptomatic Elderly Inpatients With Preserved Ejection Fraction: A Multi-Center Retrospective Study.
BACKGROUND: Echocardiographic evaluation of left ventricular diastolic dysfunction (LVDD) remains ambiguous in asymptomatic elderly patients with preserved left ventricular ejection fraction (LVEF). T...
Engineered exosomes improve myocardial cell membrane integrity and heart function in dystrophic cardiomyopathy.
BACKGROUND: Duchenne muscular dystrophy (DMD)-associated cardiomyopathy is a leading causes of premature death, yet treatment options remain limited. In this study, we developed the easily accessible ...
Morroniside Attenuates Doxorubicin-Induced Cardiotoxicity by Activating the PI3K/AKT/Nrf2/HO-1 Pathway to Inhibit Ferroptosis and Oxidative Stress.
Cardiotoxicity induced by doxorubicin (Dox) significantly contributes to increased mortality among cancer patients, yet available pharmacological interventions remain scarce. Recent studies suggest th...
Myocardial Lipid Metabolism Imbalance: The Pathological Core and Novel Diagnostic-Therapeutic Directions of Cardiovascular Diseases.
Cardiac lipid metabolism is fundamental to myocardial energy homeostasis, with fatty acid oxidation (FAO) supplying the majority of ATP in the healthy adult heart. This review synthesizes the core reg...
Preoperative MRI Intratumoral Heterogeneity Radiomics for Microvascular Invasion and Recurrence-Free Survival in HCC.
BACKGROUND AND AIMS: Microvascular invasion (MVI) is a major determinant of postoperative recurrence and poor prognosis in hepatocellular carcinoma (HCC), yet MVI cannot be reliably identified before ...
Clinical Applications of Cardiac Diffusion MRI: A Scoping Review.
Purpose To characterize the extent, clinical applications, and emerging trends of diffusion-weighted imaging (DWI) techniques in cardiac MRI using a scoping review of in vivo human studies. Materials ...
The Role of Preprocedural CT in Redo Transcatheter Aortic Valve Replacement: A Radiologist's Perspective.
As transcatheter aortic valve replacement (TAVR) has become a viable option across all surgical risk levels, younger patients are anticipated to outlive the durability of their index transcatheter hea...
Incidence and diagnostic yield of repeat imaging-based screening for hepatic arteriovenous malformations in patients with HHT.
BACKGROUND AND AIMS: Hepatic arteriovenous malformations (HAVMs) are a common visceral manifestation of hereditary hemorrhagic telangiectasia that can lead to heart failure and biliary ischemia. Curre...
A modality-agnostic coronary artery habitat model for cardiac sparing in radiotherapy.
BACKGROUND: Emerging evidence suggests that the risk of cardiotoxicity increases with increased radiation dose to coronary arteries (CAs). However, robust tools to evaluate this increased burden for c...
Atorvastatin Reduces Alcohol-Related Cardiac and Liver Tissue Damage, Oxidative Stress, Inflammation, Apoptosis, and Thiol-Disulfide Imbalance in Rats.
Excessive alcohol consumption causes significant cardio-hepatic damage. This study investigated the effects of standard (10 mg/kg) and high (40 mg/kg) doses of atorvastatin on fibrosis, hypertrophy, a...
SRM 1650b Administration to Isolated Rat Heart Aggravates Ischemia-Reperfusion Injury via Mitochondrial Dysfunction and Downregulation of PI3K/Akt Signaling Pathways.
Numerous studies have demonstrated an association between diesel particulate matter (DPM) exposure and cardiotoxicity; recent evidence further suggests that cardiomyocytes may directly internalize DPM...
Astrocyte coordinated remodelling of the dorsal horn endothelium and pain hypersensitivity.
Pain perception relies not only on sensory neurons but also on the interplay of a heterogeneous cell population, including endothelial cells, microglia, and astrocytes. Blood-spinal cord barrier dysfu...
Laparoscopic En Bloc Para-aortic Lymphadenectomy Up to the Renal Vein for Colorectal Cancer: How I Do It?
BACKGROUND: Primary tumor resection with simultaneous para-aortic lymph node dissection has curative potential in selected patients with isolated infrarenal para-aortic lymph node metastasis secondary...