Three-dimensional Mapping of Fibrosis Distribution in Desmoplakin Cardiomyopathy from Cardiac MRI.
Purpose To generate high-resolution fibrosis maps using universal ventricular coordinates for spatial characterization of fibrotic patterns across disease severity in desmoplakin cardiomyopathy. Mater...
Mitoquinone Prevents Cardiac Dysfunction by Normalizing Mitochondrial ROS and Calcium Handling in Acute Myocardial Infarction.
Acute myocardial infarction (MI) is the leading cause of heart failure (HF). However, the role of mitochondrial ROS (ROSm) in early MI dysfunction remains unclear. This study aimed to evaluate the imp...
Vendor-independent Aortic Valve Calcium Scoring in Patients with Discordant Echocardiographic Criteria of Severe Aortic Stenosis.
Purpose To apply a vendor-neutral Agatston score (vnAS) for aortic valve calcification across multiple CT systems and to aortic stenosis severity classification. Materials and Methods Anthropomorphic ...
Model-based Differentiation Between Kawasaki Disease and MIS-C: The Importance of the Mitral Valve.
BACKGROUND: Due to increasing proportion of asymptomatic severe acute respiratory syndrome coronavirus 2 infections and previously reported overlapping features, the distinction between Kawasaki disea...
Impact of Higher Versus Lower Blood Pressure Targets on Pulmonary Vascular Hemodynamics During Intensive Care After Out-of-Hospital Cardiac Arrest.
BACKGROUND: Hemodynamic management after out-of-hospital cardiac arrest (OHCA) is critical, yet the impact of vasopressor-driven mean arterial pressure (MAP) targets on pulmonary circulation and right...
Lung Pericytes: Molecular Mechanisms, Signaling Pathways, and Roles in Pulmonary Diseases.
Pericytes are specialized mural cells that ensheathe microvessels and play critical roles in maintaining vascular homeostasis, regulating angiogenesis, and coordinating tissue repair. Studies in the s...
Heart-Specific Spinal and Vagal Afferents: Transcriptomic Signatures and Optogenetically Modulated Functional Coupling With Cardiomyocytes.
Sensory neurons innervating the heart transmit chemical and mechanical cues to the central nervous system via the dorsal root ganglion (DRG) and nodose ganglion (NG). Despite their importance in cardi...
The Immuno-Cardiovascular Storm of Pre-Eclampsia: Cytokine-Mediated Endothelial Injury, Thrombosis, and Maternal Cardiovascular Instability.
Pre-eclampsia is a complex multisystem hypertensive disorder of pregnancy and a leading cause of maternal and perinatal morbidity and mortality worldwide. Increasing evidence suggests that the conditi...
Alterations in Abdominal Blood Flows After Drinking Coffee.
Coffee exerts beneficial effects on health, such as suppressing type 2 diabetes, cardiovascular disease, and fatty liver. Coffee also relieves headaches by the caffeine component decreasing blood flow...
Radiotherapy resistance in glioblastoma: Mechanistic insights and novel therapeutic approaches (Review).
Glioblastoma (GBM) is currently the most lethal type of primary brain tumor, with a median survival time of 15‑20 months despite the use of multimodal therapy. Although radiotherapy (RT) remains a cor...
Recombinant myonectin ameliorates sepsis‑induced cardiomyopathy by alleviating mitochondrial dysfunction via the AdipoR1/AMPK pathway.
Sepsis‑induced cardiomyopathy (SIC) is a common complication of sepsis and is associated with a high mortality rate; however, effective therapies remain lacking. Mitochondrial dysfunction is a key pat...
Quantitative Assessment of Myocardial Velocity and Dyssynchrony in Fontan Circulation Using MR Tissue Phase Mapping.
Magnetic resonance tissue phase mapping (TPM) has been used to encode voxel-wise myocardial motion velocity in various cardiac diseases. This study aimed to quantify alterations in myocardial motion v...
Genetic and molecular mechanisms of hereditary thoracic aortic aneurysm and dissection (Review).
Thoracic aortic aneurysm and dissection (TAAD) is a life‑threatening disease with an insidious onset and a largely elusive pathogenesis. Hereditary TAAD (HTAD) can be classified into syndromic forms, ...
Moderate downregulation of NDUFA13 promotes cardiomyocytes proliferation and heart regeneration through the glycolysis/c‑Myc/Ccnd1 axis.
The poor prognosis of heart diseases is largely attributable to the limited proliferative capacity of cardiomyocytes. Cardiomyocyte proliferation and heart regeneration has garnered increasing attenti...
Phenotypic and transcriptional changes in human brain pericytes induced by phorbol 12-myristate 13-acetate.
Pericytes are multifunctional mural cells that contribute to vascular stability, inflammation, and fibrosis in the central nervous system. Phorbol 12-myristate 13-acetate (PMA), a potent activator of ...
This study aims to investigate left atrial (LA) functional recovery following a TTS episode and assess its association with long-term major adverse cardiovascular events (MACE).
Mixed aortic valve disease (MAVD), combining aortic stenosis (AS) and regurgitation (AR), is prevalent yet understudied at mild-to-moderate severity.
This study investigated the relationship between genetic profiles and clinical, pathological, and surgical outcomes in patients undergoing septal myectomy for obstructive hypertrophic cardiomyopathy (...
Established guidelines recommend consideration for concomitant surgical aortic valve replacement (SAVR) at time of coronary artery bypass grafting (CABG) in patients with moderate aortic stenosis (AS)...