Successful destination therapy after stepwise mechanical circulatory support in a patient with cardiogenic shock following mechanical aortic valve replacement.
Patients with mechanical aortic valve replacement and end-stage heart failure present major challenges when mechanical circulatory support is required, as transvalvular devices such as the Impella 5.5...
Polysaccharide-driven gut microbial metabolism in neurodegenerative brain diseases: from SCFAs and tryptophan catabolites to neuroinflammatory regulation.
The gastrointestinal tract constitutes the principal anatomical interface of the microbiota-gut-brain axis (MGBA), orchestrating neuroimmune and metabolic crosstalk. Dysregulation within this network ...
Effect of gut bacterial extracellular vesicles on angiogenic potential and vascular integrity: positive and negative aspects.
Extracellular vesicles (EVs) are intercellular mediators in prokaryotic and eukaryotic systems that have the potential to regulate various physiological and pathological processes in recipient cells. ...
Following your heart as it takes shape.
A novel computational pipeline reveals patterns of tissue movement and growth in early heart formation and advances virtual modeling of development.
Neurocognitive outcomes after treatment of unruptured anterior communicating artery aneurysms - a systematic review.
Cognitive changes after treatment of ruptured anterior communicating artery (AComA) aneurysms have been recognized for decades. Whether such deficits occur after elective treatment of unruptured aneur...
Decoding Cardiac Development and Maturation at Single-Cell and Spatial Transcriptomic Resolution.
Recent advances in single-cell transcriptomics have revolutionized our understanding of cardiac development and maturation by resolving cellular heterogeneity, delineating lineage trajectories, and un...
Decoding Cardiovascular Disease Through Spatial Proteomics.
Cardiovascular function is tightly linked to tissue architectures, where the spatial organization of cells, extracellular matrix (ECM), vascular networks, and remodeling processes governs physiologica...
Dynamic stiffness enables stage-specific properties mediating functional endothelialization on vascular implants.
Achieving healthy, functional endothelialization represents the goal of neointima healing in cardiovascular implants but remains challenging due to strategies that fail to adapt dynamically to complex...
Carnosine-Related Metabolism in Rat Cardiomyocytes and Human Heart Tissue.
The therapeutic potential of carnosine in healthy and diseased heart models is promising; however, the understanding of carnosine and β-alanine metabolism in cardiac tissue is lacking. Exploring how t...
Low-intensity pulsed ultrasound-mediated nose-to-brain co-delivery of β-blockers and aPD-L1 enhances glioblastoma immunotherapy.
Intranasal delivery offers a direct route to the brain, circumventing the blood-brain barrier (BBB) and minimizing systemic toxicity. However, its efficiency is mainly limited by the nasal mucosal bar...
Congenital Anomalies and Variations of the Carotid and Vertebral Arteries: A Case-Based Imaging Review.
The carotid and vertebral arteries are critical components of the cerebral circulation, supplying the brain and spinal cord. Their embryologic development involves complex transformations of the aorti...
Cardiac function in zebrafish embryos is linked to an androgen receptor-adrenomedullin-proepicardium axis.
BACKGROUND: Congenital heart defects (CHDs) comprise the most common congenital malformation affecting nearly 1% of all newborns. In individuals with sex chromosome aneuploidy syndromes, however, the ...
Atlas of lysosomal aging reveals a metabolite signature shared with lysosomal storage disorders.
Lysosomal dysfunction is a well-recognized feature of aging. Here, we used a suite of tools for rapid lysosomal isolation to construct a multitissue atlas of the metabolite changes lysosomes undergo d...
Peroxisome Proliferator-Activated Receptor Delta (PPARδ) as a Metabolic Gatekeeper of Cerebrovascular Integrity.
The peroxisome proliferator-activated receptor delta (PPARδ) is a nuclear receptor highly expressed in vasculature and serves a central role in coordinating vascular and metabolic homeostasis across m...
Post-translational modification crosstalk in pulmonary arterial hypertension: mechanisms and therapeutic implications.
Pulmonary arterial hypertension (PAH) is a complex vascular disease characterized by endothelial dysfunction, pulmonary arterial smooth muscle cell (PASMC) hyperproliferation, metabolic reprogramming,...
Ventricular Assist Device Use in Single Ventricle Heart Disease: Current Outcomes and Considerations.
PURPOSE OF REVIEW: Heart failure in patients with congenital heart disease and particularly single ventricle physiology at all stages of palliation presents significant management challenges. Ventricu...
Surgical relief of supravalvular aortic stenosis.
A 10-month-old girl (72 cm, 8.86 kg) with an antenatal diagnosis of supravalvular aortic stenosis attributable to a maternally inherited elastin gene (7q11.23) deletion underwent elective repair of su...
Myocardial remodeling in valvular heart disease: pathophysiology, multimodality imaging and treatment implications.
Valvular cardiomyopathy has emerged as a key concept linking valvular heart disease (VHD) with myocardial remodeling and the development of heart failure (HF). This state-of-the-art review provides a ...
A physics-informed eikonal model for simulating arrhythmias in the human heart in real-time.
Personalized computational models of cardiac electrophysiology, referred to as cardiac digital twins, are considered a key technology for realizing precision cardiology by tailoring therapies to indiv...
Structure-Aware OCTA Segmentation for OCTA-Derived Quantitative Analysis of Cerebral Microvascular Perfusion in Ischemic Stroke.
Background: Ischemia-related optical coherence tomography angiography (OCTA) signal degradation complicates cerebral vessel segmentation and quantitative analysis. We developed a structure-aware segme...