Neurovascular Involvement in Arterial Tortuosity Syndrome Associated with a Homozygous SLC2A10 p.(Trp162Ter) Variant: Clinical, Molecular, and In Silico Characterization.
Arterial Tortuosity Syndrome (ATS) is a rare autosomal recessive connective tissue disorder caused by pathogenic variants in SLC2A10, which encodes the facilitative glucose transporter GLUT10. Althoug...
In Vitro Modelling of Obstructive Sleep Apnea by Intermittent Hypoxia of Human Embryonic Stem Cell-Derived Cardiomyocytes: Expression of ERK1/2, ERK5 and Erbin.
Obstructive sleep apnea (OSA) syndrome is characterized by repetitive nocturnal airway obstruction and is associated with intermittent hypoxia (IH). The leading cause of death among OSA patients is ca...
Dopamine D1-like and Angiotensin II Type 1 Receptors Counter-Regulate Autophagy and Cell Proliferation in Rat Embryonic Thoracic Vascular Smooth Muscle Cells.
Vascular smooth muscle cells (VSMCs), the contractile cells in the tunica media of blood vessels, maintain vascular tone. The proliferation of VSMCs is an important feature of vascular remodeling that...
Maternal hyperglycemia-induced O-GlcNAcylation of CaMKIIδ promotes mtDNA release and cardiac remodeling in offspring.
Maternal diabetes during pregnancy increases the risk of metabolic and cardiac disorders in offspring. Nevertheless, the mechanism by which intrauterine hyperglycemia affects neonatal cardiac remodeli...
Targeting therapeutic nanoparticles to the glioblastoma resection margin by harnessing postoperative blood-brain barrier disruption.
Resection surgery is the first-line therapy for high-grade glioma performed in >70% of patients with glioblastoma, typically within days of suspected diagnosis. Current protocols for follow-on chemora...
Glioblastoma: Overcoming fundamental biological and delivery barriers to therapy.
Glioblastoma remains the most aggressive primary malignant brain tumor in adults, with survival largely unchanged despite advances in molecular diagnostics and supportive care. Therapeutic failure ref...
Catheter-Directed Thrombolysis and Direct Oral Anticoagulant Class Switch to Prevent Pulmonary Embolism From Large Inferior Vena Cava Thrombus.
BACKGROUND Inferior vena cava (IVC) thrombosis is an uncommon complication of deep vein thrombosis and may be associated with a high risk of severe pulmonary embolism, particularly in the presence of ...
The ApoE-Null Golden Hamster: A Novel Model of Atherosclerosis.
Atherosclerosis is a chronic, progressive arterial disease characterized by the deposition of lipids on the inner arterial walls, leading to plaque formation and serious cardiovascular events. Traditi...
L-Arginine effectively alleviates doxorubicin-induced cardiac dysfunction by inhibiting myocardial fibrosis.
BACKGROUND: The clinical use of doxorubicin (DOX), a widely used and effective antitumor drug, is limited by its cardiotoxicity. Currently, safe and effective strategies for preventing doxorubicin-ind...
TRIM24 Impediment suppresses VSMC modulation and attenuates neointimal hyperplasia via redox and autophagy pathways.
BACKGROUND: Excessive vascular smooth muscle cell (VSMC) proliferation/survival is a critical event underlying restenosis and vascular remodeling. Tripartite motif-containing 24 (TRIM24) is an oncogen...
Effects of riociguat on right ventricular size and function in pulmonary arterial hypertension (RIVER II): a prospective, phase IV study.
BACKGROUND: Pulmonary arterial hypertension (PAH) is characterized by right ventricular (RV) pressure overload, dilatation and dysfunction, which are key prognostic determinants. While riociguat impro...
Association and Risk-Stratification Value of the Positive Remodeling Index of Middle Cerebral Artery Atherosclerotic Plaques for Perforator-Territory Infarction Based on High-Resolution Magnetic Resonance Imaging.
BACKGROUND: Atherosclerosis of the middle cerebral artery (MCA) is a major contributor to ischemic stroke, and infarcts confined to the perforator territory can produce considerable neurological dysfu...
Identification of pulmonary hypertension with pulmonary vascular surface volume ratio by non-contrast CT.
BACKGROUND: The diagnosis of pulmonary hypertension (PH) relies primarily on invasive right heart catheterization (RHC). Although imaging modalities, including echocardiography, computed tomography an...
Predictive Value of Coronary Artery Calcium Score From Nongated Chest CT Scans Compared With Gated Scans and Incidence of Cardiovascular Events.
BACKGROUND: Data on the prognostic value of incidental coronary artery calcium (CAC) from nongated chest computed tomography scans are limited. Using paired computed tomography scans from the MESA (Mu...
Blood-Brain Barrier Disruption Before Interhospital Transfer for Thrombectomy and Clinical Outcome.
BACKGROUND AND OBJECTIVES: In acute ischemic stroke with large vessel occlusion (AIS-LVO), interhospital transfer for endovascular therapy (EVT) provides an ideal therapeutic window during which neuro...
Cerebral Artery Pulsatility, Premorbid Blood Pressure, and Small Vessel Disease on Brain Imaging: A Population-Based Study.
BACKGROUND AND OBJECTIVES: Increased pulsatility of cerebral blood flow is proposed as a potential cause of cerebral small vessel disease (SVD), but the apparent association could be confounded by sha...
Influence of Surgical Timing on the Risk of Permanent Pacemaker Implantation in Acute Aortic Valve Endocarditis.
Background and Objectives: The optimal timing for surgical intervention in acute aortic valve infective endocarditis (IE) remains debated. Although European guidelines distinguish emergency, urgent, a...
Low-density lipoprotein cholesterol is inversely associated with left atrial low-voltage areas in patients with persistent atrial fibrillation: a retrospective cohort study.
BACKGROUND: Left atrial low-voltage areas (LVAs) reflect advanced atrial remodeling and are associated with postablation recurrence in patients with persistent atrial fibrillation (PerAF). However, th...
SEM1 Downregulates HSPA8 to Suppress TLR4/MyD88/NF-κB Signaling and Alleviate Myocardial I/R Injury.
Inflammation plays a pivotal role in the pathogenesis of myocardial ischemia/reperfusion (I/R) injury, highlighting inflammation suppression as a critical therapeutic strategy. The inflammatory respon...
Impact of Obstructive Sleep Apnea on Blood-Brain Barrier Permeability and Membrane Proteins.
The blood-brain barrier (BBB) carefully regulates the transport of molecules between the blood and the nervous tissue. Obstructive sleep apnea (OSA) is a chronic condition that induces structural and ...