Glycyrrhizic Acid Alleviates Atherosclerosis in ApoE(-/-) Mice via Microbial Indole-3-Lactic Acid-Mediated AhR-p65 Interaction in the Endothelium.

Glycyrrhizic acid (GL), a natural triterpenoid glycoside extracted from the "medicine food homology" herb Glycyrrhiza glabra L., exhibits potent anti-atherosclerotic effects; yet its underlying mechan...

Region- and Cell-Specific Vulnerability to ROS After Global Brain Ischemia-Reperfusion Injury: Molecular and Cellular Mechanisms.

Global brain ischemia-reperfusion (I/R) injury manifests as selective neuronal vulnerability rather than uniform tissue damage. Specific neuroanatomical regions-most notably the hippocampal cornu ammo...

Macrophage adenylyl cyclase 7 protects against myocardial ischemia/reperfusion injury in male mice.

Myocardial ischemia/reperfusion (I/R) injury undermines the clinical benefit of percutaneous coronary intervention, with cardiac macrophages playing critical roles. Here, using spatial transcriptomics...

Retrograde CTO PCI via Epicardial Collaterals: Techniques, Tools, and Risk Mitigation.

The retrograde approach to percutaneous coronary intervention (PCI) for chronic total occlusions (CTOs) is a technically demanding strategy that requires specialized expertise and knowledge. Septal co...

Impact of Aortic Annulus Size on Outcomes After Aortic Valve Replacement: The PARTNER 3 Trial.

BACKGROUND: There are limited studies comparing the impact of transcatheter aortic valve replacement (TAVR) vs surgical aortic valve replacement (SAVR) by annular size. OBJECTIVES: The aim of this pos...

SGLT2 Inhibitor on Infarct Size and LV Remodeling by CMR in Patients With AMI.

BACKGROUND: Although recent large-scale randomized trials have demonstrated that sodium-glucose cotransporter 2 (SGLT2) inhibitors following acute myocardial infarction (AMI) are safe, the mechanisms ...

Association Between Inflammatory Biomarkers And Carotid Ultrasound Parameters In The Northern Manhattan Stroke Study.

Inflammation contributes to atherosclerosis and vascular remodeling, but the immune pathways associated with distinct carotid ultrasound phenotypes, including carotid intima-media thickness (cIMT), ma...

Paeoniflorin attenuates cardiac remodeling by targeting AKT1 and suppressing the AKT/NF-κB inflammatory axis.

BACKGROUND: Cardiac remodeling induced by continuous pressure overload exacerbates heart failure (HF), yet effective treatments remain limited. This study investigates the therapeutic efficacy and und...

Spatiotemporal dynamics of blood coagulation in medium-sized vessels: numerical insights into the effects of vessel walls and blood flow.

The spatiotemporal distribution of coagulation factors fundamentally governs blood coagulation dynamics. Although these dynamics have been examined at the submillimeter scale (hundred micrometers), ho...

Transient Cardiac Dysfunction Due to New-Onset Mitral Chordal Rupture With Concomitant Congenital Absence of the Right Coronary Artery: A Case Report.

BACKGROUND Congenital absence of the right coronary artery (RCA) is a rare anomaly often identified incidentally. We report a case of transient left ventricular systolic dysfunction followed by recove...

A proposed technique for robotic port placement and arterial control of the femoral region for a peripheral arterial bypass with the Da Vinci SP system.

Robotic surgery has expanded minimally invasive options across several surgical specialties, yet adoption in peripheral vascular surgery remains limited. Groin incisions carry a high risk of wound inf...

Chrono-Nanomedicine at the Barrier: Circadian Rhythms Influence the Delivery of Donepezil Across the BCSFB.

To reach the target tissue within the central nervous system (CNS), drugs, such as donepezil (DNPZ), must overcome naturally occurring barriers. Despite its substantial pharmacological relevance, the ...

Exercise Modulates miR-276a/nej Expression and Function in the Drosophila Heart: A Possible Contribution of the Fat Body.

Cardiac rhythm and pumping function are essential outputs of cardiac homeostasis and depend on precise molecular regulation. The histone acetyltransferases CBP/p300 have been implicated in cardiac rem...

Role of Lipoprotein(a) in Aortic Valve Calcification: Inflammatory and Oxidative Mechanisms Involved.

Elevated plasma lipoprotein(a) [Lp(a)] levels represent a predominantly genetically determined risk factor for atherosclerotic cardiovascular disease and calcific aortic valve disease (CAVD). Mechanis...

Establishing Primary Cultures of Adult Mouse Cardiac Fibroblasts: A Comparative Evaluation of Three Experimental Protocols.

Cardiac fibroblasts (cFbs) are important in vitro models for studying myocardial fibrosis, extracellular matrix homeostasis, and tissue remodeling. However, establishing primary cultures from adult mo...

[Influences of hydroxylated recombinant human type III collagen on the functional characteristics of vascular smooth muscle cells].

This study was designed to investigate the effects of hydroxylated recombinant human type III collagen on the proliferation and migration of vascular smooth muscle cells (VSMCs). The viability of prim...

[Molecular mechanisms of enolase-mediated bacterial penetration of the blood-brain barrier].

Bacterial meningitis is associated with a high mortality and frequently leads to severe sequelae. Elucidating the molecular mechanisms underlying bacterial traversal of the blood-brain barrier (BBB) h...

[Morphology and anatomical variations of the left gastric vein].

Objective: To explore the gross morphology and variation characteristics of the left gastric vein (LGV) by means of cadaveric anatomical measurement and three-dimensional imaging reconstruction. Metho...

Pericardial migration of ventriculoperitoneal shunt: a case report with review of the literature.

BACKGROUND: Ventriculoperitoneal (VP) shunting is the standard surgical treatment for hydrocephalus, yet it is associated with a wide range of complications. Distal catheter migration into the pericar...

Trdn-as directs m6A-dependent transcriptional termination for accurate triadin isoform switching, preventing aberrant dyads and cardiomyopathy.

Heart failure is a leading cause of mortality, and impaired cardiac excitation-contraction coupling represents a potentially fatal trigger for myocardial dysfunction. Long non-coding RNAs (lncRNAs) ca...