Hepatocellular Carcinoma Presenting With Extensive Portal Vein Tumour Thrombus Without Evidence of Underlying Liver Cirrhosis or Steatosis: A Case Report.
AIMS/BACKGROUND: Most cases of hepatocellular carcinoma (HCC) develop in the setting of chronic liver disease (CLD), usually with chronic inflammation, fibrosis, or cirrhosis. The case aims to highlig...
In silico pipeline for GSK 3β inhibitor discovery in Alzheimer's disease using pharmacophore screening, docking, ADME filtering, and MD validation.
Glycogen synthase kinase-3β (GSK-3β) is a key therapeutic target for Alzheimer's disease, but identifying safe, brain-penetrant inhibitors remains difficult. This study aimed to discover novel CNS-act...
Recurrent embolic cerebellar infarction due to bow hunter's syndrome of the non-dominant vertebral artery.
We describe a rare presentation of bow hunter's syndrome (BHS) involving the non-dominant vertebral artery (VA), leading to recurrent embolic cerebellar infarction. A male in his mid-70s presented wit...
Association between liver fibrosis severity and impaired myocardial glucose metabolism in subjects with different degrees of glucose tolerance.
INTRODUCTION: Increasing evidence suggests that liver fibrosis is an independent risk factor for cardiovascular disease. However, the mechanisms underlying this increased risk are still unsettled. The...
Dose-dependent sensitivity of human three-dimensional chromatin to a heart disease-linked transcription factor.
Dosage-sensitive transcription factors (TFs) underlie altered gene regulation in human developmental disorders, and cell type-specific gene regulation is linked to the reorganization of three-dimensio...
Single-cell multiomics and chromatin structure reveal gene-regulatory dynamics in heart failure.
Heart failure is a leading cause of morbidity and mortality, yet gene-regulatory mechanisms driving cell type-specific pathologic responses remain undefined. Here, we present the cell type-resolved tr...
Methyltransferase METTL1 Upregulates USF2 in a m7G-Dependent Manner to Accelerate Septic Cardiomyopathy by Inactivating PINK1/Parkin-Mediated Mitophagy.
Septic cardiomyopathy (SCM) is a severe complication of sepsis, characterized by high mortality. The activation of mitophagy in cardiomyocytes is crucial for alleviating SCM. The N7-methylguanosine (m...
Glymphatic Dysfunction and Aquaporin-4 Dysregulation in Traumatic Brain Injury and Brain Tumors: A Review.
The glymphatic system is a cerebrospinal fluid-interstitial fluid exchange pathway that clears metabolic waste and maintains brain fluid homeostasis. Aquaporin-4 (AQP4), a water channel at astrocytic ...
The Role of Echocardiography in the Assessment of Epicardial Adipose Tissue: A Systematic Review and Meta-analysis.
BACKGROUND: Epicardial adipose tissue (EAT) is a metabolically active visceral fat depot implicated in cardiometabolic and cardiovascular (CV) disease. Although cardiac magnetic resonance (CMR) and ca...
The New Spine of Access to the Brain's Secrets: Extracellular Vesicles from Cerebrospinal Fluid Liquid Biopsies in CNS Diseases and Blood-Brain Barrier Research.
Liquid biopsy is emerging as a powerful approach for less invasive biomarker discovery, with extracellular vesicles (EVs) in cerebrospinal fluid (CSF) showing promise for the assessment of central ner...
Micro- and Nanoplastics in Cardiovascular Toxicology: Human Tissue Detection, Clinical Phenotypes, and Adverse Outcome Signals.
Micro- and nanoplastics (MNPs) have emerged from a diffuse environmental concern to a plausible cardiovascular exposure with potential clinical relevance. The current evidence base is heterogeneous: h...
SIRT5 Attenuates Doxorubicin-Induced Acute Cardiac Injury by Modulating PHB2 Succinylation and the Mitophagic Response.
Doxorubicin (DOX)-induced cardiac injury remains a major limitation of chemotherapy and is closely linked to mitochondrial dysfunction, oxidative stress, and dysregulated mitophagy. Sirtuin 5 (SIRT5),...
Large-scale synthetic data enable digital twins of human excitable cells.
Individual variability shapes how diseases manifest, how patients respond to therapy and how rare phenotypes arise. Conventional experimental approaches obscure variation by averaging which limits mec...
Blood-brain barrier water permeability is elevated in type 2 diabetes and obesity: associations with cognitive function and metabolic markers.
BACKGROUND: Type 2 diabetes (T2D) and obesity are established risk factors for Alzheimer's disease and related dementias, yet the cerebrovascular mechanisms linking metabolic dysfunction to cognitive ...
In vitro multi-organ invasion model for exploring cardiac resistance to cancer metastasis.
Despite the systemic spread of cancer, the ventricular myocardium is one of the least common sites of metastasis-a phenomenon that remains poorly understood. To examine this, we develop the Multi-orga...
TGFβ-Dependent Epithelial-Mesenchymal Plasticity in Immortalized Human Atrial Epicardial Cells: An mRNA Profiling Study.
The adult mammalian heart exhibits limited regenerative capacity. Although the epicardium contributes to cardiac injury responses and remodeling, expandable adult human in vitro models for investigati...
Immunological Reprogramming in Cardiomyopathies: From Cardiomyocyte Injury to Disease of the Cardiac Immune Ecosystem.
Cardiomyopathies have traditionally been regarded as disorders driven primarily by cardiomyocyte injury resulting from genetic defects, infection, metabolic stress, or toxic exposure. This paradigm ha...
The Clearance-Centered Bottleneck in Alzheimer's Disease: From Coupled Glymphatic-Lymphatic Circuits to Therapeutic Opportunities.
While anti-amyloid-beta (Aβ) monoclonal antibodies have achieved substantial success in reducing plaque burden, their modest clinical impact highlights an "efficacy ceiling" that necessitates a re-eva...
Loss of Vascular TMEM16A Impairs Cerebral Autoregulation and Exacerbates Ischemia-reperfusion Injury.
TMEM16A forms a Ca²⁺-activated Cl⁻ channel in vascular mural cells (smooth muscle cells and pericytes) that generates depolarizing Cl⁻ efflux upon intracellular Ca²⁺ elevation, thereby amplifying agon...
Computational modeling of tissue damage preceding aortic dissection: a coupled biphasic and reactive viscoelastic framework.
Aortic dissection is a life-threatening pathology characterized by the progressive delamination of adjacent lamellar units within the aortic media. Because this internal damage propagates predominantl...