Transcriptomic landscape of human cardiac aging: identification of cardioselective age-associated genes and predictive modeling.

Age is a major risk factor for cardiovascular disease, yet the molecular mechanisms underlying human cardiac aging are not fully understood. Using bulk RNA sequencing data from the Genotype-Tissue Exp...

Diverticulitis-Associated Mesenteric Venous Thrombophlebitis: A Case Report and Systematic Review of Diagnosis, Management, and Outcomes.

Diverticulitis can rarely seed the portal‑mesenteric venous system, causing septic thrombophlebitis with morbidity and management uncertainty. This study systematically reviewed diverticulitis‑associa...

[A brief analysis of the core component of the meridian system from an anatomical perspective].

Through a brief review of early meridian theories and their historical development, it is deemed that anatomical evidence played a pivotal role in the formation and evolution of the theory of meridian...

[Electroacupuncture improves myocardial ischemia inflammatory injury by regulating the homeostasis of myocardial Th17/Treg cells through JAK1/STAT3 signaling in rats].

OBJECTIVES: To observe the effect of electroacupuncture (EA) on the homeostasis of Th17/Treg cells and the expressions of key proteins of the janus kinase 1/signal transducer and activator of transcri...

Targeting Kinase Signaling in Glioblastoma: Structural Optimization, Blood-Brain Barrier Dynamics and Combinatorial Translational Strategies.

Small-molecule kinase inhibitors offer a compelling therapeutic strategy for glioblastoma, yet their clinical efficacy remains severely limited by blood-brain barrier penetration and active efflux tra...

Interventional Tricuspid Valve Replacement: A Structured Sequence of Procedures.

The EVOQUE valve system is the first approved tricuspid valve replacement system developed specifically for the percutaneous implantation of a biological tricuspid valve in patients diagnosed with sym...

Real-Time Two-Photon Imaging of Brain Endothelial NAD+ Metabolism in Mice.

We present a reproducible workflow for real-time visualization of nicotinamide adenine dinucleotide (NAD+) biosensor-channel responses in brain microvascular endothelial cells in living mice using cra...

Aortic root motion artifacts on non-electrocardiographic-gated chest CT: A comparison of five CT scanner protocols including an ultrafast wide-detector CT system.

This study aimed to compare aortic root motion artifacts across 5 computed tomography (CT) scanner protocols on non-electrocardiographic-gated contrast-enhanced chest CT, with particular attention to ...

Association of transverse sinus stenosis and dominant venous sinus drainage pattern with chronic migraine: A matched case-control study.

Recent studies have indicated that transverse sinus stenosis (TSS) is an imaging feature in patients with chronic migraine (CM). However, the clinical significance of this imaging finding in CM remain...

The infraorbital vein: embryology, anatomy, histology, variations, and clinical relevance.

The infraorbital vein (IOV) is a small but clinically important component of the deep midfacial venous system, linking the infraorbital region, orbit, and infratemporal fossa. Despite its close associ...

Signaling mechanisms and dynamics governing the myocardial-epicardial fate switch during human cardiogenesis.

The signaling mechanisms and developmental dynamics that govern the divergence of myocardial and epicardial lineages during human heart development remain poorly understood. Here, we developed a human...

Lapatinib Induces Ferroptosis in Cardiomyocytes by Regulating ATF4/GPX4.

The TKI-targeted agent lapatinib has been applied in clinical oncology for the management of multiple malignancies. Nonetheless, its therapeutic benefit is restricted by cardiotoxic effects that endan...

Prognostic implications of superior mesenteric vein/portal vein resection and histologic venous invasion in BR/LA PDAC after neoadjuvant therapy.

BACKGROUND: Superior mesenteric vein/portal vein (SMV/PV) resection is often required in borderline resectable or locally advanced pancreatic ductal adenocarcinoma (BR/LA PDAC) after neoadjuvant thera...

Venous sinus stenting for pulsatile tinnitus secondary to venous sinus stenosis: a dual-center retrospective cohort study.

Pulsatile tinnitus (PT) can emerge due to stenosis in the venous sinus, which leads to turbulent venous flows and increased pressures within the veins. Stenting of the venous sinus (VSS) is a potentia...

A sex-specific perspective on coronary microvascular dysfunction in HFpEF: from vascular to myocardial disease.

Heart failure with preserved ejection fraction (HFpEF) is the most prevalent form of heart failure and is characterized by high morbidity, limited therapeutic options, and marked biological heterogene...

S1P receptor 1 signaling reduces arterial thrombosis via up-regulation of endothelial thrombomodulin expression.

Sphingosine-1-phosphate (S1P) is a key mediator in the cardiovascular system with controversial effects on coagulation. We hypothesized that S1P reduces platelet adhesion and thrombus formation by up-...

[Triangular mesh reconstruction based on CT angiography in the diagnosis and treatment of left ventricular subepicardial aneurysm rupture following radiofrequency ablation for premature ventricular contractions: a case report].

左心室心外膜下室壁瘤是射频消融治疗室性早搏罕见但严重的并发症，可能破裂导致急性心脏压塞甚至猝死。该文报告1例59岁女性患者，因症状性室性早搏接受射频消融治疗，术中发生心脏压塞，通过联合应用经胸超声心动图、心脏磁共振成像、CT血管造影及三角网格重建，明确诊断左心室心外膜下室壁瘤，经心包穿刺置管引流及保守治疗后好转出院。三角网格重建结合超声心动图可能有助于评估左心室心外膜下室壁瘤破裂风险，为临床实践提...

[Predictive value of the anatomical structure of pulmonary vein antrum for the recurrence of paroxysmal atrial fibrillation after radiofrequency catheter ablation].

Objective: To investigate the predictive value of pulmonary vein antrum anatomy for recurrence after radiofrequency catheter ablation (RFCA) in patients with paroxysmal atrial fibrillation (PAF). Meth...

[Effects of CPAP therapy on blood pressure and vascular endothelial function in hypertensive patients with moderate-to-severe obstructive sleep apnea].

Objective: To investigate the effect of continuous positive airway pressure (CPAP) therapy on blood pressure and vascular endothelial function in patients with hypertension and moderate-to-severe obst...

Immunocytochemical staining for lymphatic and blood vessels with frozen sections: using LYVE-1 for lymphatic vessel and von Willebrand factor for blood vessel marker.

Almost all human tissues are supplied with lymphatic vessels, yet histological structure and function of lymphatic vessels is still elusive. Most immunocytochemical studies have been performed with th...