Serial failure of the brain clearance continuum in Alzheimer's disease: mechanisms and therapeutic perspectives.
Alzheimer's disease (AD) is usually regarded as a neurodegenerative disorder defined by amyloid-β (Aβ) deposition and abnormal tau accumulation. Increasing evidence suggests that reduced clearance of ...
A loss-of-function polymorphism in the propeptide of lysyl oxidase exacerbates atherosclerosis.
A single-nucleotide missense polymorphism (rs1800449, R158Q) in the propeptide domain of lysyl oxidase (LOX-PP) is associated with increased risk of coronary artery disease (CAD) independent of change...
Strategy-based revascularization for complex femoropopliteal disease: endovascular-first versus surgical bypass in contemporary practice.
AIM: To compare the outcomes of endovascular treatment (EVT) and surgical bypass (BP) for the management of complex femoropopliteal (FP) artery disease. METHODS: This retrospective single-centre cohor...
Dl-3-n-Butylphthalide Protects Human Brain Microvascular Endothelial Cells Against Ischemic Injury Through Dual Modulation of HIF1α/VEGF-Mediated Angiogenesis and COX2-Mediated Inflammation.
BACKGROUND: Stroke remains a leading cause of death and disability worldwide. Endothelial dysfunction plays a central role in both acute ischemic injury and subsequent recovery. In this study, we inve...
Alcohol Metabolism into Acetaldehyde in Developing Cerebral Arteries.
Alcohol exposure during pregnancy leads to fetal alcohol spectrum disorders (FASD), yet the mechanisms through which alcohol disrupts the developing cerebrovasculature remain poorly defined. Acetaldeh...
Valve-Related Outcomes up to Six Years of a Next-Generation Bovine Pericardial Bioprosthesis Compared with Its Predecessor: A Propensity-Matched Analysis.
Background: Current ESC/EACTS guidelines recommend bioprosthetic valves for aortic valve replacement (AVR) in patients > 65 years, yet their use is increasing among younger individuals. The INSPIRIS R...
Influence of wall distensibility on local hemodynamics at the normal carotid bifurcation: a fluid-structure interaction study.
The role of local hemodynamics on atherosclerosis at the carotid bifurcation has been the subject of study by computational fluid-dynamics (CFD) simulations for over three decades. Nevertheless, quest...
Intracranial Mitochondrial Microparticles Promote Cerebral Edema via Endothelial Injury in Stroke.
Vascular endothelial injury underlies the development of severe complications following acute ischemic stroke. While mitochondrial microparticles (mtMPs) compromise endothelial integrity, their mechan...
A hybrid phenomenological finite element model of transcatheter aortic valve leaflet behaviour under non-circular annular deployment: in vitro validation and biomechanical insights.
Transcatheter aortic valves (TAVs) typically operate on non-circular rings, but the impact of annular ellipticity on valve mechanics remains insufficiently quantified. In this study, we present a fini...
Haemodynamic and biomechanical biomarker analysis of carotid fibromuscular dysplasia via fluid-structure interaction.
This study aims to investigate the biomechanical behaviour of the carotid artery in patients with fibromuscular dysplasia (FMD) disease. Carotid FMD is an arterial disease lacking either inflammatory ...
Quantitative computerized analysis demonstrates strongly compartmentalized tissue deformation patterns underlying mammalian heart tube formation.
The quantitative analysis of tissue deformation at cellular resolution remains an important challenge in mammalian organogenesis. Here, we developed a new computational workflow to extract regional an...
Protein corona guided albumin-binding paclitaxel nanoparticles for treatment of intracranial tumors.
Albumin-bound paclitaxel (Abraxane) exhibits potent antitumor activity, but its suboptimal pharmacokinetics and the restrictive blood-brain barrier (BBB) greatly limit the broader application of album...
Middle meningeal artery arteriovenous shunting after surgical evacuation of chronic subdural hematoma: a retrospective angiographic cohort study.
Arteriovenous shunting involving the middle meningeal artery (MMA) has been reported after cranial trauma, neurosurgical procedures, and endovascular interventions. However, its angiographic frequency...
Loss of ATP-Dependent Citrate Lyase Drives Left Ventricular Dysfunction by Metabolic Remodeling.
BACKGROUND: Metabolic adaptation and maladaptation are hallmarks of the failing heart and may be a target for therapeutic interventions. For example, sustained glucose oxidation during cardiac stress ...
ROS produced in mitochondria entrapped by self-assembly peptide fibers for target therapy of glioma.
Brain glioma is a highly energy-dependent malignant tumor. Sonodynamic therapy (SDT) provides a noninvasive and effective approach for brain glioma therapy. Reactive oxygen species (ROS) from sonosens...
Atherosclerosis results from cellular and extracellular changes in the arterial wall, preceded by molecular shifts that initiate disease and drive tissue conversion, yet these changes are not yet full...
The optimal transfusion strategy in patients with acute myocardial infarction (AMI) and anemia may be influenced by sex differences in pathophysiology and cardiovascular outcomes. The Myocardial Ische...
The heart transplant allocation system is evolving in response to increasing demand for donor organs, technological advances, and changes in medical decision-making. In this evolving landscape, the hi...
Low resting ankle-brachial index (ABI) is a marker of poor cardiovascular outcomes. Whether modest decrements in ABI translate into higher risks of major adverse limb events (MALE) is unclear because ...
Interleukin (IL)-6 has emerged as a promising target for cardiovascular disease (CVD) prevention. Better understanding IL-6's contribution to CVD events in community-based, diverse cohorts and in clin...