Patient-specific iPSC-derived ECs identify QKI-7 as a key regulator of endothelial dysfunction and potential therapeutic target in diabetes.
Diabetic vascular complications remain a major cause of morbidity and mortality, yet the molecular mechanisms underlying endothelial dysfunction in diabetes remain incompletely understood. Endothelial...
[Clinical efficacy of pedicled double-perforator flap of the inferior epigastric artery in reconstructing the soft tissue defects following resection of cutaneous malignant tumors].
Objective: To investigate the clinical efficacy of pedicled double-perforator flap of the inferior epigastric artery in reconstructing the soft tissue defects following resection of cutaneous malignan...
Molecular MRI monitoring of cyclodextrin therapy in murine abdominal aortic aneurysms.
Abdominal aortic aneurysms (AAAs) are characterized by progressive extracellular matrix (ECM) degradation and inflammation of the aortic wall. 2-Hydroxypropyl-β-cyclodextrin (cyclodextrin) has shown p...
Impact of Microaxial Flow Pump on Coronary Flow Dynamics in Normal Hearts: An Experimental Evaluation.
The effects of microaxial flow pump (mAFP) support on coronary flow (CF) are well characterized in failing hearts, but its impact on CF in normal hearts under different levels of left ventricular (LV)...
Global research trends and clinical theme evolution in robot-assisted nephrectomy with venous tumor thrombectomy for renal cell carcinoma: a bibliometric and visualization analysis.
Robot-assisted nephrectomy with renal vein or inferior vena cava (IVC) tumor thrombectomy is a technically demanding procedure used in selected patients with renal cell carcinoma (RCC) and venous tumo...
Robotic pancreaticoduodenectomy with venous resection and reconstruction: a systematic review of perioperative, vascular, oncological and survival outcomes.
Robotic pancreaticoduodenectomy with venous resection and reconstruction (RPD-VR) is one of the most technically challenging procedures in hepatopancreaticobiliary surgery. While acceptance of robotic...
Gastrodin mitigates cisplatin-induced cardiotoxicity in Swiss albino mice by restoring redox homeostasis and modulating the p62-Keap1-Nrf2 Axis.
BACKGROUND: Cisplatin (CP) chemotherapy can elicit clinically meaningful cardiac injury, and the additional use of effective cardioprotective agents is a pressing need. This study investigated the pro...
Multifactorial acute kidney injury with findings suggestive of arcuate venous thrombosis: a case report.
Renal arcuate vein thrombosis (RAVT) is a rare and often underrecognized cause of acute kidney injury (AKI) that typically requires renal biopsy for diagnosis. We report a 29-year-old man who develope...
Endotype-guided medical therapy and symptom response in ANOCA.
BACKGROUND: Invasive coronary functional testing enables the classification of angina with non-obstructive coronary arteries (ANOCA) into distinct endotypes. However, real-world data linking endotype ...
Quantitative assessment of systolic and diastolic left ventricular energy loss using vector flow mapping in healthy participants: a retrospective observational study.
BACKGROUND: Energy loss (EL) derived from vector flow mapping (VFM) is an indicator of intraventricular flow efficiency in the left ventricle. However, standardized reference values in adults have not...
Multi-organ transcriptome profiling in an isogenic cachexia-inducing xenograft model to dissect host responses across heart, liver, kidney, and muscle.
Cancer cachexia is a debilitating systemic syndrome that affects a substantial proportion of patients with advanced malignancy and is associated with impaired treatment tolerance, reduced quality of l...
Extra-Anatomical Aortic Bypass for Infected Aortic Arch Stent Graft: A Case Series.
BACKGROUND Aorto-aortic extra-anatomical bypass is a specialized surgical intervention primarily used to manage complex vascular complications, including stent graft infections after endovascular aort...
A non-bactericidal antimicrobial peptide provides protective effect against bacterial sepsis via regulation of antimicrobial immunity and vascular endothelial functions.
The anti-infective properties of bactericidal antimicrobial peptides (AMPs) have been extensively studied, yet the functions and mechanisms of non-bactericidal AMPs in sepsis remain poorly understood....
A 79-Year-Old Woman With Stage IIIB Lung Squamous Cell Carcinoma Presenting With Late-Onset Durvalumab‑Associated Myocarditis Requiring Differentiation From Pericardial Invasion.
BACKGROUND Durvalumab is a humanized monoclonal antibody and immune checkpoint inhibitor used for the treatment of advanced non-small cell lung cancer. Myocarditis, particularly in late-onset cases, i...
Isolation and Culture of Mouse Brain Microvascular Endothelial Cells.
Brain microvascular endothelial cells (BMECs) are the main cellular component of the blood-brain barrier (BBB) and play a key role in regulating molecular transport and maintaining central nervous sys...
Regional Cardiac Remodeling Signatures Across Atria and Ventricles Revealed by Vein of Marshall and Anterior Interventricular Vein Sampling.
The incidence rate of atrial fibrillation is increasing year by year, which is characterized by time progression, but its mechanism is unknown. Vein of Marshall (VOM), also known as the left atrial ob...
Robot-Assisted Radical Prostatectomy in a Patient with Pre-existing Femoral Crossover Bypass Graft: Multidisciplinary Management and Outcomes.
Robot-assisted radical prostatectomy (RARP) has become the standard surgical treatment for localized clinically significant prostate cancer, yet in patients with pre-existing pelvic vascular grafts, s...
Gamma Oscillations, Sensory Stimulation, and Glymphatic Function: Toward User-Friendly Auditory Interventions for Brain Health in Aging and Neurodegeneration.
The glymphatic system is a brain-wide clearance pathway that facilitates the removal of interstitial solutes, including amyloid-β, and plays a critical role in maintaining brain homeostasis. Impairmen...