Differential Regulation of Protective and Harmful Renin Transcripts by the cAMP/PKA/Ca(2+)-Pathway in Cardiac H9c2 Cells.

Two different renin isoforms are expressed in extrarenal tissues. The classical renin-a has been associated with detrimental effects, whereas renin-b exerts protective effects during glucose starvatio...

Knowledge graph visualization and bibliometric analysis of research on coronary artery lesions in Kawasaki disease.

BACKGROUND: Coronary artery lesions (CAL) complicating Kawasaki disease (KD) are a central concern affecting the long-term cardiovascular health of affected children. This study aimed to systematicall...

Analysis of risk factors associated with intimal hyperplasia in arteriovenous fistulas among patients undergoing hemodialysis.

Arteriovenous fistula (AVF) intimal hyperplasia (IH) is a major pathological basis of AVF stenosis and dysfunction in patients undergoing maintenance hemodialysis. This single-center retrospective obs...

Association between aggregate index of systemic inflammation and in-hospital new-onset AF in myocardial infarction with nonobstructive coronary arteries: A retrospective cohort study.

In recent years, with a growing understanding of coronary microvascular dysfunction, myocardial infarction with nonobstructive coronary arteries (MINOCA) has been proposed as a distinct type of myocar...

Effects of methylphenidate on the human vascular endothelium.

Methylphenidate (MPH) is a widely used psychostimulant for treating attention-deficit/hyperactivity disorder (ADHD). Emerging epidemiological findings suggest that MPH treatment increases the risk of ...

Pre-existing vertebrojugular fistula unmasked following an uncomplicated internal jugular vein cannulation and its management.

A vertebrojugular fistula (VJF) is a vascular malformation characterised by abnormal communication between the vertebral artery (VA) and the internal jugular vein (IJV). It can occur following neck tr...

Focused ultrasound blood-brain barrier opening reveals a paradoxical remote metabolic response in the primate brain.

Low-intensity focused ultrasound (LIFU) is a promising technique for opening the blood-brain barrier (BBB) for drug delivery, but its physiological consequences in remote brain regions remain a major ...

The Exercise-CTSS-AD Axis: a novel framework for understanding exercise-induced neuroprotection in Alzheimer's disease.

Disease-modifying therapies for Alzheimer's disease (AD) targeting amyloid-β and tau have consistently failed, highlighting the urgent need for innovative therapeutic strategies. Cathepsin S (CTSS), a...

Targeting canonical TGFβ/SMAD3 and ERK1/2 signaling in human valve interstitial cells to modulate immune-fibrotic responses in rheumatic heart disease.

Rheumatic heart disease (RHD) is a chronic sequel of acute rheumatic fever characterized by sustained inflammation, fibrosis, and valve degeneration; however, the underlying processes remain unclear. ...

Global sensitivity analysis through causal discovery for an electromechanical cardiac model.

The rapid development of advanced cardiac imaging and modeling technologies has significantly increased the number of parameters required to accurately characterize cardiac function, thereby improving...

Preoperative CT Assessment of Portal Vein Contact Length Predicts Poor Prognosis in Resectable Pancreatic Head Cancer.

PURPOSE: To investigate whether preoperative computed tomography (CT)-based tumor-portal/superior mesenteric vein (PV/SMV) contact angle and contact length predict pathological venous invasion and ref...

Social Isolation, Loneliness and Subclinical Atherosclerosis.

PURPOSE OF REVIEW: Social isolation and loneliness have emerged as important cardiovascular risk factors, yet the biological mechanisms linking adverse social experiences to cardiovascular disease rem...

Managing a right sinking sinus anatomy during valve-sparing aortic root replacement.

We present a case of an otherwise healthy young male with a 5.0 cm aortic root aneurysm complicated by a thin "sinking" right sinus of Valsalva who underwent a valve-sparing aortic root replacement wi...

Reading between the lines: NLP, symptom documentation, and a new era of cardiovascular prognostication

Blood‒brain barrier permeability assessment: from biomimetic models to multimodal imaging.

The blood‒brain barrier (BBB) is a vital physiological structure that maintains the microenvironmental homeostasis in the central nervous system (CNS). Imbalances in its permeability play a key role i...

Interleukin-1β and Interleukin-6 Signaling Differentially Regulate ABC Transporter Activity and Amyloid-β Handling in Primary Porcine Brain Endothelial Cells.

Impaired amyloid-β clearance at the blood-brain barrier (BBB) contributes to Alzheimer's disease (AD), yet the regulation of endothelial transport processes under neuroinflammatory conditions remains ...

Mesenchymal Stem Cells of Epicardial Adipose Tissue Show Differences in Immunophenotype and Osteogenic Potential in Patients with Coronary and Non-Coronary Heart Disease.

Coronary artery calcification (CAC) is a pressing issue in cardiology. Mesenchymal stem cells (MSCs) derived from epicardial adipose tissue (EAT) may serve as a source of osteoblasts in the cardiovasc...

The neglected second wound: a qualitative study of patients' experiences of lower limb vascular harvesting for coronary artery bypass grafting.

OBJECTIVE: This study aimed to understand the experiences and feelings of patients undergoing lower limb vein harvesting for coronary artery bypass grafting (CABG). DESIGN: Qualitative, phenomenologic...

[Role of miR-146b-5p in hyperoxia-induced pulmonary vascular remodeling in neonatal rats: mechanisms based on the regulation of ferroptosis].

OBJECTIVES: To investigate the role and mechanism of miR-146b-5p in pulmonary vascular remodeling in neonatal rats with bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH) induced by...

Ultrasound Identification of Right Internal Jugular Vein Occlusion After Catheterization in a Premature Infant.

BACKGROUND Right internal jugular vein (RIJV) catheterization is a routine clinical procedure for gastrointestinal surgery. The conventional blind puncture method is often unable to detect vascular an...