Multimethod-guided discovery of novel α-pyrone dimers with cardiomyocyte-protective activity against cold ischemia injury from the coral-derived Talaromyces sp. TJ403-AL05.
Guided by molecular networking, HSQC-based DeepSAT, and SMART analyses, a chemical investigation of the coral-derived fungus Talaromyces sp. TJ403-AL05 led to the isolation and identification of talad...
A Review of the Therapeutic Potential of Stem Cell-Derived Nanocarriers to Treat Neurological Disorders.
Neurological disorders (NDs) are characterized by substantial loss of specific neurons, with Alzheimer's and Parkinson's diseases being the most frequent NDs and nearly 99% of all "foreign substances"...
DUSP1 Inhibits Mechanotransduction and MAPK Signalling to Alleviate Myocardial Cell Hypertrophy.
Hypertrophic Cardiomyopathy (HCM) is one of the significant causes of heart failure. This study aimed to identify and validate potential therapeutic targets for HCM through bioinformatics analysis and...
Introduction to Single-Cell Physiologically-Based Pharmacokinetic (scPBPK) Models.
The current investigation introduces single-cell physiologically based pharmacokinetic (scPBPK) models to gain insight into drug disposition at the cellular scale. The transition from standard PBPK (s...
Toward multilevel therapeutic targeting of medial arterial calcification in chronic kidney disease.
Despite decades of investigation, effective therapies for medial arterial calcification in chronic kidney disease remain lacking. Emerging therapeutic targets increasingly extend beyond systemic drive...
Challenging Anatomic and Pathologic Features for Transcatheter Aortic Valve Replacement Planning.
Segmentation and processing of CT datasets for transcatheter aortic valve replacement (TAVR) planning is now an essential part of the transcatheter heart valve team process. Output for TAVR planning i...
Downregulation of circ_0001112 Enhances Myocardial Infarction Through Regulation of miR-324-5p/CDK6 Axis.
Myocardial infarction (MI) usually results in severe heart failure (HF), and patients suffer from the repercussions of MI, elucidation of the pathological basis of MI is crucial to optimize the preven...
Complex Posterior Chest Wall Reconstruction Using Bilateral Deep Inferior Epigastric Perforator Flaps After Failed Latissimus Dorsi Free Flap: A Case Report.
Radical resection of posterior chest wall sarcomas may result in extensive composite defects exposing lung parenchyma, prosthetic material, and spinal instrumentation, while simultaneously exhausting ...
Rethinking Transradial Compression Band Practice.
BACKGROUND: Transradial access (TRA) is a standard approach to cardiac catheterization. Following the procedure, air-filled compression bands are often used to achieve hemostasis at the access site. D...
Hepatic Artery Doppler Haemodynamic Indices as Imaging Biomarkers of Disease Activity in Adults with Chronic Hepatitis B: Correlation with Viral Load and Serum Alanine Transaminase.
BACKGROUND: Hepatitis B is a common cause of chronic liver disease. Early features of fibrosis are detectable using ultrasound and Doppler imaging. AIMS: This study evaluated relationships between hep...
miR-138-5p Inhibits Aortic Valve Interstitial by Targeting SLC39A14 and Activating Nrf2 Signaling.
This study explored the role of miR-138-5p in calcific aortic valve disease (CAVD), focusing on its regulation of osteogenic differentiation in human aortic valve interstitial cells (hAVICs) and under...
Genotype-Dependent Effects of Mechanical Stretch and GATA4-Targeted Compound 3i-1262 in Cardiomyopathy Patient-Derived hiPSC-Cardiomyocytes.
Genetic hypertrophic and dilated cardiomyopathies (HCM and DCM, respectively) are characterised by structural and functional abnormalities that can lead to heart failure. However, current therapies ma...
A systematic mapping review of studies reporting the effects of spaceflight on cardiovascular outcomes.
This systematic review aimed to characterize the landscape of cardiovascular research in the context of spaceflight and its Earth-based analogs. In collaboration with subject matter experts from the A...
Sex differences in regulatory mechanisms of the cardiovascular system during simulated hypokinesia.
The study examined sex-specific differences in the autonomic response to simulated hypokinesia. Nine healthy males (23±3 years) and nine females (26±3 years) underwent 5‑day dry immersion. Heart rate ...
The mechanism and protection of microgravity induced cardiac remodeling.
Prolonged exposure to a microgravity setting results in alterations to the hearts of astronauts. While multiple studies have documented the impact of microgravity on cardiovascular well-being, there i...
On the History of Hepatic Vein Catheterization.
Hepatic vein catheterization (HVC) in man was first performed 80 years ago in the wake of right-sided heart catheterization. Several new methods, recognitions and concepts followed, especially the ind...
Comparison of Complications According to the Number of Venous Anastomoses in Lower Extremity Reconstruction.
BACKGROUND: Venous congestion remains a leading cause of early free flap failure in lower extremity reconstruction. Although double venous anastomosis has been proposed to enhance venous outflow, its ...
The Neurovascular Niche: A Gathering Venue for Neuroinflammation and Remyelination in Multiple Sclerosis.
In the central nervous system (CNS), the tissue microenvironment is continuously monitored and regulated to secure the unobstructed function of neurons and of their networks. This is a key function of...
Cholinesterase inhibitors in people with dementia with Lewy bodies and cardiac conduction abnormalities.
Bradycardia due to cardiac conduction abnormalities is prevalent in patients with dementia with Lewy bodies possibly due to autonomic dysfunction and neurodegeneration. Cholinesterase inhibitors remai...
Ventricular Tachycardia Ablation in a Case of Calcified Left Ventricular Apical Aneurysm.
Calcific left ventricular (LV) apical aneurysms represent a highly arrhythmogenic substrate for ventricular tachycardias (VTs), posing unique challenges for mapping and catheter ablation. Dense calcif...