Incretin-Based Therapies in Doxorubicin-Induced Cardiotoxicity: A Systematic Review of GLP-1 and Dual GIP/GLP-1 Agonists.
Doxorubicin (DOX)-induced cardiotoxicity remains a major limitation of cancer therapy. Incretin-based therapies are established cardiometabolic agents with pleiotropic cardiovascular effects; however,...
Cardiac regeneration and repair: the emerging mechanisms and therapeutic approaches.
Myocardial infarction, characterized by irreversible cardiomyocyte loss, progressive cardiac fibrosis and subsequent deteriorated heart function, constitute an intractable global health burden. Promot...
Epigenetic Control of Mammalian Cardiomyocyte Proliferation.
PURPOSE OF REVIEW: Postnatal shutdown of the mammalian cardiomyocyte cell cycle underpins limited regenerative capacity of the adult heart. An epigenetic programme regulates a switch at birth from a p...
Relationship of glymphatic dysfunction and frontothalamic structure with cognitive impairment in attention deficit hyperactivity disorder.
Cognitive deficits constitute a core feature of attention deficit hyperactivity disorder (ADHD), yet their underlying neurobiological mechanisms remain incompletely understood. This study investigates...
Echocardiography Assessment of Cardiac Function and Pulmonary Hypertension in Lambs.
Premature birth is strongly associated with cardiac dysfunction, including impaired ventricular function and altered cardiac structure, which can lead to progressive heart failure and other short- and...
Chronic Infection and Cardiac Aging: a New Perspective on Pathogen-Associated Cardiomyopathy.
Cardiovascular diseases remain the primary driver of global mortality, with advanced age serving the most significant risk factor for their development and progression. Emerging evidence suggests that...
ALPK3 regulates cardiomyocyte apoptosis through the Notch1 signaling pathway.
ALPK3, a gene associated with pediatric cardiomyopathy, plays a pivotal role in cardiac development, yet the regulatory mechanisms governing its involvement in cardiomyocyte apoptosis are still not we...
RBM20 variants disrupt Ca(2+) handling and metabolism in dilated and non-compaction cardiomyopathy stem cell models.
Mutations in the splice-regulator RBM20 cause heart failure with reduced ejection fraction (HFrEF), typically manifesting as dilated cardiomyopathy (DCM). Mutations at position 634 in the RS-domain ca...
This 2025 report from the ESC Atlas project is the fifth in a biennial series. It presents and compares updated cardiovascular disease (CVD) statistics for more than 50 of the ESC member countries. Th...
Cardiovascular disease in China: epidemiological evolution and implications.
Cardiovascular disease (CVD) has remained a predominant cause of mortality in China for several decades, experiencing notable epidemiological transitions. Numerous recent studies have provided valuabl...
Bisphenol F (BPF) is a common substitute for bisphenol A and the most prevalent bisphenol compound in diverse plastic manufacturing applications. However, the potential toxicity of BPF remains largely...
Synergistic reproductive toxicity of lambda-cyhalothrin and thiamethoxam via oxidative stress and blood-testis barrier dysfunction in rats.
Excessive pesticide use regularly pollutes the environment and endangers both human and animal health. The current study aimed to examine the main mechanism by which the combined action of pyrethroids...
Fractional Flow Reserve-Guided Renal Artery Stenting in Renovascular Hypertension: 1-Year Results of the FAIR Study.
BACKGROUND: Whether fractional flow reserve (FFR)-guided revascularization improves outcomes in atherosclerotic renal artery stenosis (ARAS) remains uncertain. OBJECTIVES: This study will evaluate whe...
Comparative Efficacy of Endovascular Revascularization Modalities for Symptomatic Infrapopliteal Peripheral Artery Disease: A Network Meta-Analysis.
BACKGROUND: Patients with infrapopliteal peripheral artery disease (PAD) are at elevated risk for amputation and mortality. The comparative efficacy of available endovascular devices for treating infr...
Procedural Strategies for Optimal Transcatheter Aortic Valve Replacement: An International Position Statement.
The extension of transcatheter aortic valve replacement (TAVR) to younger patients with longer life expectancy has driven a shift in focus toward procedural optimization, with the goals of maximal cli...
Anaesthetic management of a child with anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) and supravalvular aortic stenosis (SVAS) associated with Williams-Beuren syndrome undergoing combined coronary reimplantation and supravalvular aortoplasty.
A child with genetically confirmed Williams-Beuren syndrome, having moderate supravalvular aortic stenosis, was diagnosed with anomalous origin of the left coronary artery from the pulmonary artery (A...
Vertex epidural haematoma secondary to sagittal sinus involvement: a surgical challenge.
Epidural haematomas (EDHs) involving the superior sagittal sinus (SSS) are rare and carry significant surgical risks. We report a man in his 50s who sustained an occipital head injury secondary to a t...
Effect of Sublingual Nitroglycerin on Absolute Coronary Blood Flow: A Randomized Double-Blind Placebo-Controlled Mechanistic Study.
BACKGROUND: Nitrates remain a key drug class in the management of angina pectoris. However, their effect on coronary blood flow has never been convincingly demonstrated in humans. OBJECTIVES: The aim ...
AI Model Improves Interpretation of Cardiac Magnetic Resonance Imaging Scans.
Interpreting cardiac magnetic resonance imaging scans takes significant time and specialist expertise. In this News and Perspectives article, JMIR Correspondent Shalini Kathuria Narang reports on new ...
Extracellular Vesicles in Stroke: Drivers of Brain-Body Network Crosstalk.
Mounting evidence reframes stroke not as a single cerebral event but as a dynamic brain-body network disorder. Extracellular vesicles (EVs)-lipid bilayer-enclosed particles released by virtually all c...