Breaching the Blood-Brain Barrier: Evolving Strategies for Central Nervous System Disease in Adult Acute Lymphoblastic Leukemia.

PURPOSE OF REVIEW: Central nervous system (CNS) involvement in adult acute lymphoblastic leukemia (ALL) remains a critical determinant of treatment failure and long-term survival. This review provides...

Acid-sensing ion channels in the vasculature: emerging roles in systemic and pulmonary circulations.

Acid-sensing ion channels (ASICs) are proton-gated members of the degenerin/epithelial sodium channel family that are emerging as multifaceted regulators of cardiovascular function. ASICs expressed in...

Preoperative vascular parameters and proximal splenorenal shunt patency in pediatric extrahepatic portal vein thrombosis.

PURPOSE: Shunt thrombosis is an important complication after proximal splenorenal shunt (PSRS) in children with extrahepatic portal vein thrombosis (EHPVT). We evaluated whether preoperative vascular ...

Heparin combined with urokinase therapy for the treatment of acute portal vein thrombosis in children.

PURPOSE: Acute portal vein thrombosis (PVT) poses a significant threat to life, with mortality rates ranging from 20% to 50%. However, a clear consensus on the management of acute PVT in children is l...

[Clinical characteristics of middle-age and elderly patients with active Takayasu arteritis disease].

Objective: To draw attention to the diagnosis of active Takayasu arteritis (TAK) in middle-aged and elderly patients and to analyze the clinical characteristics of this population. Methods: Clinical d...

MiR-378a-3p Promotes Macrophage Polarization from M1 to M2 for Cardiac Repair after Infarction Via Trem1.

Acute myocardial infarction (AMI) triggers a robust inflammatory response in which macrophage polarization critically influences cardiac repair, yet the regulatory role of microRNAs remains largely un...

IGF2BP1 modulates ZDHHC5-mediated NLRP3 inflammasome activation to promote mitochondrial damage and foam cell formation of vascular smooth muscle cells.

BACKGROUND: Smooth muscle-derived foam cell formation is a key to atherosclerosis (AS) development. Mitochondrial damage is involved in AS pathogenesis S. Here, effects of ZDHHC5 on mitochondrial dama...

Post-viral myocarditis.

Myocarditis is an inflammatory disease of the myocardium characterized by complex histological, immunological and molecular changes occur that may ultimately lead to post-viral cardiomyopathy, a speci...

The mtROS-Mitophagy Axis: A Decisive Redox Hub Governing Cell Fate in Myocardial Ischemia-Reperfusion Injury.

The progression of myocardial ischemia-reperfusion injury (MIRI) is orchestrated by a decisive, bidirectional dialogue between mitochondrial reactive oxygen species (mtROS) and mitophagy. This review ...

Monocytes and macrophages are critically involved in the pathogenesis of atherosclerotic cardiovascular disease (ASCVD). Accumulating evidence indicates that monocytes and macrophages can develop inna...

Long QT syndrome (LQTS) is a life-threatening genetic disorder characterized by prolonged QT intervals on electrocardiograms. Congenital forms are mostly associated with variants in the KCNQ1 and KCNH...

Interferon (IFN) alpha (IFNα) and lambda3 (IFNλ3) constitute first line responses of immunity against SARS-CoV-2 infection by increasing interferon-stimulated genes (ISGs). Prolonged IFN production ma...

Vascular Deletion of HDAC6 Ameliorates Diabetic Retinal Microangiopathy and Diabetic Retinopathy in an Experimental Model of Type 1 Diabetes.

Diabetic retinopathy (DR) is a leading cause of vision loss among working-age adults and is characterized by progressive retinal microvascular dysfunction driven by hyperglycemia-induced inflammation ...

Whole-body irradiation causes long-term impairments in the maintenance and function of naïve CD4 T cells specific for self- and non-self-antigens.

Whole-body irradiation (WBI) consistently induces radiation-associated lymphopenia, a complication linked to poor prognosis and reduced overall survival. Understanding the quantitative and qualitative...

Endothelial injury biomarker EASIX predicts mortality risk in adults with chronic obstructive pulmonary disease: A retrospective cohort study.

Endothelial dysfunction has been implicated in the pathogenesis and progression of chronic obstructive pulmonary disease (COPD). This study aimed to examine the utility of the Endothelial Activation a...

Cross-sectional association between relative fat mass and abdominal aortic calcification among US adults: The NHANES 2013 to 2014.

Abdominal aortic calcification (AAC) serves as a reliable predictor of future cardiovascular incidents. This study investigated the association between relative fat mass (RFM) and AAC in US adults. A ...

Interaction of Listeria monocytogenes with the human choroid plexus endothelium in vitro: impact on invasion of the epithelium.

In the central nervous system (CNS), the highly vascularized choroid plexus (CP) produces the cerebrospinal fluid (CSF) and also acts as a blood-CSF barrier (BCSFB). Due to its location in the ventric...

The MEK inhibitor trametinib incurs mitochondrial injury and induces innate immune responses in the mouse heart.

Trametinib (Trm) is a highly selective mitogen-activated protein kinase kinase (MEK) inhibitor that potently and persistently abrogates extracellular signal-regulated kinase 1/2 activation. Trm initia...